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Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens.
APMIS. 2005 Oct; 113(10):655-63.A

Abstract

The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, beta-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to beta-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from < or = 0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides.

Authors+Show Affiliations

Laboratory of Clinical Microbiology, Department of Clinical Sciences L. Sacco, University of Milan, Italy. lorenzo.drago@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16309423

Citation

Drago, L, et al. "Kinetic Bactericidal Activity of Telithromycin, Azithromycin and Clarithromycin Against Respiratory Pathogens." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 113, no. 10, 2005, pp. 655-63.
Drago L, De Vecchi E, Nicola L, et al. Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens. APMIS. 2005;113(10):655-63.
Drago, L., De Vecchi, E., Nicola, L., Legnani, D., & Gismondo, M. R. (2005). Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 113(10), 655-63.
Drago L, et al. Kinetic Bactericidal Activity of Telithromycin, Azithromycin and Clarithromycin Against Respiratory Pathogens. APMIS. 2005;113(10):655-63. PubMed PMID: 16309423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens. AU - Drago,L, AU - De Vecchi,E, AU - Nicola,L, AU - Legnani,D, AU - Gismondo,M R, PY - 2005/11/29/pubmed PY - 2006/2/9/medline PY - 2005/11/29/entrez SP - 655 EP - 63 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 113 IS - 10 N2 - The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, beta-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to beta-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from < or = 0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides. SN - 0903-4641 UR - https://www.unboundmedicine.com/medline/citation/16309423/Kinetic_bactericidal_activity_of_telithromycin_azithromycin_and_clarithromycin_against_respiratory_pathogens_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0903-4641&amp;date=2005&amp;volume=113&amp;spage=655 DB - PRIME DP - Unbound Medicine ER -