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Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors.
Brain Res. 2005 Dec 14; 1065(1-2):147-51.BR

Abstract

The present study investigated a potential role for cannabinoid CB(1) and CB(2) receptors in capsaicin-evoked hypothermia. Capsaicin (1 mg/kg, s.c.) caused rapid and significant hypothermia in rats. Pretreatment with SR 141716A (1, 2.5 and 5 mg/kg, i.p.), a CB(1) antagonist, or SR 144528 (1, 2.5 and 5 mg/kg, i.p.), a CB(2) antagonist, did not affect capsaicin-induced hypothermia. In separate experiments, the hypothermia caused by WIN 55212-2 (5 mg/kg, i.m.), a cannabinoid agonist, was not significantly altered by capsazepine (10 and 30 mg/kg, i.p.) or SB 366791 (2 mg/kg, i.p.), a novel TRPV1 antagonist. These data suggest that capsaicin causes hypothermia by a CB(1)- and CB(2)-independent mechanism, and that WIN 55212-2 causes hypothermia by a TRPV1-independent mechanism.

Authors+Show Affiliations

Department of Pharmaceutical Sciences and Pharmacology, Temple University School of Pharmacy and Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16309633

Citation

Ding, Zhe, et al. "Capsaicin Evokes Hypothermia Independent of Cannabinoid CB1 and CB2 Receptors." Brain Research, vol. 1065, no. 1-2, 2005, pp. 147-51.
Ding Z, Cowan A, Rawls SM. Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors. Brain Res. 2005;1065(1-2):147-51.
Ding, Z., Cowan, A., & Rawls, S. M. (2005). Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors. Brain Research, 1065(1-2), 147-51.
Ding Z, Cowan A, Rawls SM. Capsaicin Evokes Hypothermia Independent of Cannabinoid CB1 and CB2 Receptors. Brain Res. 2005 Dec 14;1065(1-2):147-51. PubMed PMID: 16309633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors. AU - Ding,Zhe, AU - Cowan,Alan, AU - Rawls,Scott M, Y1 - 2005/11/23/ PY - 2005/06/24/received PY - 2005/10/14/revised PY - 2005/10/15/accepted PY - 2005/11/29/pubmed PY - 2006/2/16/medline PY - 2005/11/29/entrez SP - 147 EP - 51 JF - Brain research JO - Brain Res VL - 1065 IS - 1-2 N2 - The present study investigated a potential role for cannabinoid CB(1) and CB(2) receptors in capsaicin-evoked hypothermia. Capsaicin (1 mg/kg, s.c.) caused rapid and significant hypothermia in rats. Pretreatment with SR 141716A (1, 2.5 and 5 mg/kg, i.p.), a CB(1) antagonist, or SR 144528 (1, 2.5 and 5 mg/kg, i.p.), a CB(2) antagonist, did not affect capsaicin-induced hypothermia. In separate experiments, the hypothermia caused by WIN 55212-2 (5 mg/kg, i.m.), a cannabinoid agonist, was not significantly altered by capsazepine (10 and 30 mg/kg, i.p.) or SB 366791 (2 mg/kg, i.p.), a novel TRPV1 antagonist. These data suggest that capsaicin causes hypothermia by a CB(1)- and CB(2)-independent mechanism, and that WIN 55212-2 causes hypothermia by a TRPV1-independent mechanism. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/16309633/Capsaicin_evokes_hypothermia_independent_of_cannabinoid_CB1_and_CB2_receptors_ DB - PRIME DP - Unbound Medicine ER -