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Melanocortin-5 receptor: a marker of human sebocyte differentiation.
Peptides. 2006 Feb; 27(2):413-20.P

Abstract

Melanocortin receptors (MC1R-MC5R) and their ligands (melanocyte-stimulating hormone (MSH) and adrenocorticotrophin hormone (ACTH)) have been shown to influence physiological functions of cells and organs, including exocrine glands. Since relatively little is known about MC5R expression and function in the human sebaceous gland, we examined expression of MC5R by immunohistochemistry and RT-PCR in human sebaceous cells in vivo and in vitro. In human skin, MC5R was detected only in differentiating, lipid-laden sebaceous cells but not in basal, undifferentiated sebaceous cells. Similarly, in cultured human sebocytes MC5R was only detectable at the onset of differentiation and in fully differentiated cells displaying prominent lipid granules. The lipid profile of the cultured and differentiated human sebocytes was shown to be human sebum-specific using (14)C-acetate labeling and high performance thin layer chromatography. Our studies suggest that MC5R is a marker of human sebocyte differentiation.

Authors+Show Affiliations

The Johnson and Johnson Skin Research Center, CPPW, 199 Grandview Road, Skillman, NJ 08558, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16309786

Citation

Zhang, Li, et al. "Melanocortin-5 Receptor: a Marker of Human Sebocyte Differentiation." Peptides, vol. 27, no. 2, 2006, pp. 413-20.
Zhang L, Li WH, Anthonavage M, et al. Melanocortin-5 receptor: a marker of human sebocyte differentiation. Peptides. 2006;27(2):413-20.
Zhang, L., Li, W. H., Anthonavage, M., & Eisinger, M. (2006). Melanocortin-5 receptor: a marker of human sebocyte differentiation. Peptides, 27(2), 413-20.
Zhang L, et al. Melanocortin-5 Receptor: a Marker of Human Sebocyte Differentiation. Peptides. 2006;27(2):413-20. PubMed PMID: 16309786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melanocortin-5 receptor: a marker of human sebocyte differentiation. AU - Zhang,Li, AU - Li,Wen-Hwa, AU - Anthonavage,Michael, AU - Eisinger,Magdalena, Y1 - 2005/11/22/ PY - 2004/08/02/received PY - 2005/05/13/accepted PY - 2005/11/29/pubmed PY - 2006/5/26/medline PY - 2005/11/29/entrez SP - 413 EP - 20 JF - Peptides JO - Peptides VL - 27 IS - 2 N2 - Melanocortin receptors (MC1R-MC5R) and their ligands (melanocyte-stimulating hormone (MSH) and adrenocorticotrophin hormone (ACTH)) have been shown to influence physiological functions of cells and organs, including exocrine glands. Since relatively little is known about MC5R expression and function in the human sebaceous gland, we examined expression of MC5R by immunohistochemistry and RT-PCR in human sebaceous cells in vivo and in vitro. In human skin, MC5R was detected only in differentiating, lipid-laden sebaceous cells but not in basal, undifferentiated sebaceous cells. Similarly, in cultured human sebocytes MC5R was only detectable at the onset of differentiation and in fully differentiated cells displaying prominent lipid granules. The lipid profile of the cultured and differentiated human sebocytes was shown to be human sebum-specific using (14)C-acetate labeling and high performance thin layer chromatography. Our studies suggest that MC5R is a marker of human sebocyte differentiation. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/16309786/Melanocortin_5_receptor:_a_marker_of_human_sebocyte_differentiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(05)00454-7 DB - PRIME DP - Unbound Medicine ER -