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Rapid deswelling of semi-IPNs with nanosized tracts in response to pH and temperature.

Abstract

Porous linear-polymer penetrating networks (semi-IPNs) were prepared by the radical polymerization of acrylic acid (AAc) inside porous poly(N-isopropylacrylamide) hydrogels with "nano-sized tract networks (nano-tracts)." The deswelling behavior was investigated by measuring the time course of the swelling ratio change of the semi-IPNs just after the temperature or pH was changed. Although the incorporation of PAAc linear chains into the PNIPAAm hydrogel networks should facilitate deswelling, nonporous semi-IPNs showed only a slow thermoresponse under low pH conditions, and a slow pH-response under a high temperature. On the other hand, the porous semi-IPNs showed a rapid deswelling in response to either a change in pH or temperature, regardless of the environment, presumably due to the nano-tracts through which the water was rapidly released from the hydrogel without any interference by network shrinking. The novel network design of these nano-tracted semi-IPNs may be useful for high performance, dual molecule-release functions.

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  • Authors+Show Affiliations

    ,

    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.

    , ,

    Source

    MeSH

    Acrylic Resins
    Algorithms
    Calorimetry, Differential Scanning
    Excipients
    Hydrogels
    Hydrogen-Ion Concentration
    Kinetics
    Nanostructures
    Particle Size
    Temperature

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16310274

    Citation

    TY - JOUR T1 - Rapid deswelling of semi-IPNs with nanosized tracts in response to pH and temperature. AU - Asoh,Taka-Aki, AU - Kaneko,Tatsuo, AU - Matsusaki,Michiya, AU - Akashi,Mitsuru, Y1 - 2005/11/28/ PY - 2005/06/01/received PY - 2005/09/13/revised PY - 2005/10/20/accepted PY - 2005/11/29/pubmed PY - 2006/2/28/medline PY - 2005/11/29/entrez SP - 387 EP - 94 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 110 IS - 2 N2 - Porous linear-polymer penetrating networks (semi-IPNs) were prepared by the radical polymerization of acrylic acid (AAc) inside porous poly(N-isopropylacrylamide) hydrogels with "nano-sized tract networks (nano-tracts)." The deswelling behavior was investigated by measuring the time course of the swelling ratio change of the semi-IPNs just after the temperature or pH was changed. Although the incorporation of PAAc linear chains into the PNIPAAm hydrogel networks should facilitate deswelling, nonporous semi-IPNs showed only a slow thermoresponse under low pH conditions, and a slow pH-response under a high temperature. On the other hand, the porous semi-IPNs showed a rapid deswelling in response to either a change in pH or temperature, regardless of the environment, presumably due to the nano-tracts through which the water was rapidly released from the hydrogel without any interference by network shrinking. The novel network design of these nano-tracted semi-IPNs may be useful for high performance, dual molecule-release functions. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/16310274/Rapid_deswelling_of_semi_IPNs_with_nanosized_tracts_in_response_to_pH_and_temperature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(05)00547-X ER -