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Relation of inflammation to peripheral arterial disease in the national health and nutrition examination survey, 1999-2002.
Am J Cardiol 2005; 96(11):1579-83AJ

Abstract

The relation between inflammation and peripheral arterial disease (PAD) is not well characterized. This study examined this relation and its consistency across important subgroups in a cross-sectional, nationally representative sample of the adult United States population. C-reactive protein (CRP), fibrinogen, leukocyte count, and PAD were assessed in a sample of 4,787 participants aged>or=40 years in the National Health and Nutrition Examination Survey 1999-2002. PAD was defined as an ankle-brachial blood pressure index <0.9. Graded relations were present between inflammatory markers and PAD. The multivariate adjusted odds ratios of PAD associated with the highest versus the lowest quartile of CRP, fibrinogen, and leukocyte count were 2.14 (95% confidence interval [CI] 1.41 to 3.25), 2.49 (95% CI 1.27 to 4.85), and 1.67 (95% CI 0.84 to 3.31), respectively (each p trend<0.05 across quartiles). Associations between inflammation and PAD were similar across gender, obesity, and diabetic subgroups. However, the odds ratios of PAD for the highest CRP quartile versus the 3 lowest quartiles were 3.10 (95% CI 1.76 to 5.45) for non-Hispanic blacks versus 1.50 (95% CI 0.98 to 2.28) for non-Hispanic whites and 1.11 (95% CI 0.57 to 2.17) for Mexican Americans (p interaction=0.049) and 5.59 (95% CI 1.82 to 17.17) for patients aged 40 to 54 years versus 2.01 (95% CI 1.13 to 3.58) for patients aged 55 to 69 years and 0.98 (95% CI 0.65 to 1.48) for patients aged>or=70 years (p interaction=0.018). Odds ratios of PAD for the highest fibrinogen quartile versus the lowest 3 quartiles were 3.26 (95% CI 1.69 to 6.28) for current smokers versus 0.83 (95% CI 0.51 to 1.35) for never smokers (p interaction=0.006). In conclusion, in the general United States adult population, inflammation is independently associated with PAD.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. rwildman@tulane.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16310445

Citation

Wildman, Rachel P., et al. "Relation of Inflammation to Peripheral Arterial Disease in the National Health and Nutrition Examination Survey, 1999-2002." The American Journal of Cardiology, vol. 96, no. 11, 2005, pp. 1579-83.
Wildman RP, Muntner P, Chen J, et al. Relation of inflammation to peripheral arterial disease in the national health and nutrition examination survey, 1999-2002. Am J Cardiol. 2005;96(11):1579-83.
Wildman, R. P., Muntner, P., Chen, J., Sutton-Tyrrell, K., & He, J. (2005). Relation of inflammation to peripheral arterial disease in the national health and nutrition examination survey, 1999-2002. The American Journal of Cardiology, 96(11), pp. 1579-83.
Wildman RP, et al. Relation of Inflammation to Peripheral Arterial Disease in the National Health and Nutrition Examination Survey, 1999-2002. Am J Cardiol. 2005 Dec 1;96(11):1579-83. PubMed PMID: 16310445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of inflammation to peripheral arterial disease in the national health and nutrition examination survey, 1999-2002. AU - Wildman,Rachel P, AU - Muntner,Paul, AU - Chen,Jing, AU - Sutton-Tyrrell,Kim, AU - He,Jiang, Y1 - 2005/10/13/ PY - 2005/04/27/received PY - 2005/07/07/revised PY - 2005/07/07/accepted PY - 2005/11/29/pubmed PY - 2006/1/4/medline PY - 2005/11/29/entrez SP - 1579 EP - 83 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 96 IS - 11 N2 - The relation between inflammation and peripheral arterial disease (PAD) is not well characterized. This study examined this relation and its consistency across important subgroups in a cross-sectional, nationally representative sample of the adult United States population. C-reactive protein (CRP), fibrinogen, leukocyte count, and PAD were assessed in a sample of 4,787 participants aged>or=40 years in the National Health and Nutrition Examination Survey 1999-2002. PAD was defined as an ankle-brachial blood pressure index <0.9. Graded relations were present between inflammatory markers and PAD. The multivariate adjusted odds ratios of PAD associated with the highest versus the lowest quartile of CRP, fibrinogen, and leukocyte count were 2.14 (95% confidence interval [CI] 1.41 to 3.25), 2.49 (95% CI 1.27 to 4.85), and 1.67 (95% CI 0.84 to 3.31), respectively (each p trend<0.05 across quartiles). Associations between inflammation and PAD were similar across gender, obesity, and diabetic subgroups. However, the odds ratios of PAD for the highest CRP quartile versus the 3 lowest quartiles were 3.10 (95% CI 1.76 to 5.45) for non-Hispanic blacks versus 1.50 (95% CI 0.98 to 2.28) for non-Hispanic whites and 1.11 (95% CI 0.57 to 2.17) for Mexican Americans (p interaction=0.049) and 5.59 (95% CI 1.82 to 17.17) for patients aged 40 to 54 years versus 2.01 (95% CI 1.13 to 3.58) for patients aged 55 to 69 years and 0.98 (95% CI 0.65 to 1.48) for patients aged>or=70 years (p interaction=0.018). Odds ratios of PAD for the highest fibrinogen quartile versus the lowest 3 quartiles were 3.26 (95% CI 1.69 to 6.28) for current smokers versus 0.83 (95% CI 0.51 to 1.35) for never smokers (p interaction=0.006). In conclusion, in the general United States adult population, inflammation is independently associated with PAD. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16310445/Relation_of_inflammation_to_peripheral_arterial_disease_in_the_national_health_and_nutrition_examination_survey_1999_2002_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)01444-X DB - PRIME DP - Unbound Medicine ER -