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Adverse reactions to foods.

Abstract

Food allergy encompasses a variety of immune-mediated adverse reactions to foods. IgE-mediated, cell-mediated, and mixed-mechanism food allergy disorders are recognized. Over the past 2 decades, the prevalence of food allergy doubled and its phenotypic expression increased in Westernized societies. Major food allergens have been identified for many common foods. Laboratory diagnosis of food allergy relies heavily on the detection of food-specific IgE antibodies, but novel approaches include tests for T-cell-mediated disorders and tests for prediction of tolerance. OFC remains the diagnostic standard for food allergy. Management of food allergy focuses on avoidance of the offending foods, nutritional support, and prompt recognition and treatment of acute food allergic reactions. Anti-IgE monoclonal antibody is the first potential therapy for food allergy that is under-going testing in clinical trials.

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  • Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.

    Source

    The Medical clinics of North America 90:1 2006 Jan pg 97-127

    MeSH

    Adult
    Child
    Food Hypersensitivity
    Humans

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    16310526

    Citation

    Nowak-Wegrzyn, Anna, and Hugh A. Sampson. "Adverse Reactions to Foods." The Medical Clinics of North America, vol. 90, no. 1, 2006, pp. 97-127.
    Nowak-Wegrzyn A, Sampson HA. Adverse reactions to foods. Med Clin North Am. 2006;90(1):97-127.
    Nowak-Wegrzyn, A., & Sampson, H. A. (2006). Adverse reactions to foods. The Medical Clinics of North America, 90(1), pp. 97-127.
    Nowak-Wegrzyn A, Sampson HA. Adverse Reactions to Foods. Med Clin North Am. 2006;90(1):97-127. PubMed PMID: 16310526.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adverse reactions to foods. AU - Nowak-Wegrzyn,Anna, AU - Sampson,Hugh A, PY - 2005/11/29/pubmed PY - 2006/2/17/medline PY - 2005/11/29/entrez SP - 97 EP - 127 JF - The Medical clinics of North America JO - Med. Clin. North Am. VL - 90 IS - 1 N2 - Food allergy encompasses a variety of immune-mediated adverse reactions to foods. IgE-mediated, cell-mediated, and mixed-mechanism food allergy disorders are recognized. Over the past 2 decades, the prevalence of food allergy doubled and its phenotypic expression increased in Westernized societies. Major food allergens have been identified for many common foods. Laboratory diagnosis of food allergy relies heavily on the detection of food-specific IgE antibodies, but novel approaches include tests for T-cell-mediated disorders and tests for prediction of tolerance. OFC remains the diagnostic standard for food allergy. Management of food allergy focuses on avoidance of the offending foods, nutritional support, and prompt recognition and treatment of acute food allergic reactions. Anti-IgE monoclonal antibody is the first potential therapy for food allergy that is under-going testing in clinical trials. SN - 0025-7125 UR - https://www.unboundmedicine.com/medline/citation/16310526/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-7125(05)00095-7 DB - PRIME DP - Unbound Medicine ER -