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Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions.
Neuroscience. 2006; 138(3):901-10.N

Abstract

Extensive evidence from rat and human studies indicates that glucocorticoid hormones influence cognitive performance. Posttraining activation of glucocorticoid-sensitive pathways dose-dependently enhances the consolidation of long-term memory. Glucocorticoid effects on memory consolidation rely on noradrenergic activation of the basolateral amygdala and interactions of the basolateral amygdala with other brain regions. Glucocorticoids interact with the noradrenergic system both at a postsynaptic level, increasing the efficacy of the beta-adrenoceptor-cyclic AMP/protein kinase A system, as well as presynaptically in brainstem noradrenergic cell groups that project to the basolateral amygdala. In contrast, memory retrieval and working memory performance are impaired with high circulating levels of glucocorticoids. Glucocorticoid-induced impairment of these two memory functions also requires the integrity of the basolateral amygdala and the noradrenergic system. Such critical interactions between glucocorticoids and noradrenergic activation of the basolateral amygdala have important consequences for the role of emotional arousal in enabling glucocorticoid effects on these different memory functions.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, 92697-3800, USA. broozend@uci.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16310958

Citation

Roozendaal, B, et al. "Glucocorticoids Interact With Emotion-induced Noradrenergic Activation in Influencing Different Memory Functions." Neuroscience, vol. 138, no. 3, 2006, pp. 901-10.
Roozendaal B, Okuda S, de Quervain DJ, et al. Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. Neuroscience. 2006;138(3):901-10.
Roozendaal, B., Okuda, S., de Quervain, D. J., & McGaugh, J. L. (2006). Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. Neuroscience, 138(3), 901-10.
Roozendaal B, et al. Glucocorticoids Interact With Emotion-induced Noradrenergic Activation in Influencing Different Memory Functions. Neuroscience. 2006;138(3):901-10. PubMed PMID: 16310958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. AU - Roozendaal,B, AU - Okuda,S, AU - de Quervain,D J-F, AU - McGaugh,J L, Y1 - 2005/11/28/ PY - 2005/04/28/received PY - 2005/07/15/revised PY - 2005/07/25/accepted PY - 2005/11/29/pubmed PY - 2006/5/19/medline PY - 2005/11/29/entrez SP - 901 EP - 10 JF - Neuroscience JO - Neuroscience VL - 138 IS - 3 N2 - Extensive evidence from rat and human studies indicates that glucocorticoid hormones influence cognitive performance. Posttraining activation of glucocorticoid-sensitive pathways dose-dependently enhances the consolidation of long-term memory. Glucocorticoid effects on memory consolidation rely on noradrenergic activation of the basolateral amygdala and interactions of the basolateral amygdala with other brain regions. Glucocorticoids interact with the noradrenergic system both at a postsynaptic level, increasing the efficacy of the beta-adrenoceptor-cyclic AMP/protein kinase A system, as well as presynaptically in brainstem noradrenergic cell groups that project to the basolateral amygdala. In contrast, memory retrieval and working memory performance are impaired with high circulating levels of glucocorticoids. Glucocorticoid-induced impairment of these two memory functions also requires the integrity of the basolateral amygdala and the noradrenergic system. Such critical interactions between glucocorticoids and noradrenergic activation of the basolateral amygdala have important consequences for the role of emotional arousal in enabling glucocorticoid effects on these different memory functions. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16310958/Glucocorticoids_interact_with_emotion_induced_noradrenergic_activation_in_influencing_different_memory_functions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(05)00840-7 DB - PRIME DP - Unbound Medicine ER -