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Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract.

Abstract

Anti-inflammatory and free radical scavenging activities of the methanolic extract of Ricinus communis (RCM) (Euphorbiaceae) Linn. root was studied in Wistar albino rats. The methanolic extract at doses 250 and 500 mg/kg p.o. exhibited significant (P<0.001) anti-inflammatory activity in carrageenan-induced hind paw edema model. The extract at the dose of 500 mg/kg p.o. also exhibited significant (P<0.001) anti-inflammatory activity in cotton pellet granuloma model. The methanolic extract showed significant free radical scavenging activity by inhibiting lipid peroxidation initiated by carbon tetrachloride and ferrous sulphate in rat liver and kidney homogenates. The extract enhanced free radical scavenging activity of stable radical 2,2-diphenyl-1-picryl-hydrazyl (DPPH*), nitric oxide and hydroxyl radical in in vitro assay methods. The results of the study indicate that the methanolic extract of Ricinus communis root possess significant anti-inflammatory activity in acute and chronic inflammatory models in rats. The observed pharmacological activity may be due to the presence of phytochemicals like flavonoids, alkaloids and tannins present in the plant extract with various biological activities.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology, C.L. Baid Metha College of Pharmacy, Old Mahabalipuram Road, Jyothi Nagar, Thorapakkam, Chennai 600096, India. arilavarasan@yahoo.co.in

    ,

    Source

    Journal of ethnopharmacology 103:3 2006 Feb 20 pg 478-80

    MeSH

    Animals
    Anti-Inflammatory Agents
    Carrageenan
    Dose-Response Relationship, Drug
    Edema
    Free Radical Scavengers
    Free Radicals
    Granuloma
    India
    Kidney
    Liver
    Plant Extracts
    Plant Roots
    Rats
    Rats, Wistar
    Ricinus

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16310994

    Citation

    Ilavarasan, Raju, et al. "Anti-inflammatory and Free Radical Scavenging Activity of Ricinus Communis Root Extract." Journal of Ethnopharmacology, vol. 103, no. 3, 2006, pp. 478-80.
    Ilavarasan R, Mallika M, Venkataraman S. Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. J Ethnopharmacol. 2006;103(3):478-80.
    Ilavarasan, R., Mallika, M., & Venkataraman, S. (2006). Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. Journal of Ethnopharmacology, 103(3), pp. 478-80.
    Ilavarasan R, Mallika M, Venkataraman S. Anti-inflammatory and Free Radical Scavenging Activity of Ricinus Communis Root Extract. J Ethnopharmacol. 2006 Feb 20;103(3):478-80. PubMed PMID: 16310994.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. AU - Ilavarasan,Raju, AU - Mallika,Moni, AU - Venkataraman,Subramanian, Y1 - 2005/11/28/ PY - 2004/12/21/received PY - 2005/06/23/revised PY - 2005/07/22/accepted PY - 2005/11/29/pubmed PY - 2007/7/31/medline PY - 2005/11/29/entrez SP - 478 EP - 80 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 103 IS - 3 N2 - Anti-inflammatory and free radical scavenging activities of the methanolic extract of Ricinus communis (RCM) (Euphorbiaceae) Linn. root was studied in Wistar albino rats. The methanolic extract at doses 250 and 500 mg/kg p.o. exhibited significant (P<0.001) anti-inflammatory activity in carrageenan-induced hind paw edema model. The extract at the dose of 500 mg/kg p.o. also exhibited significant (P<0.001) anti-inflammatory activity in cotton pellet granuloma model. The methanolic extract showed significant free radical scavenging activity by inhibiting lipid peroxidation initiated by carbon tetrachloride and ferrous sulphate in rat liver and kidney homogenates. The extract enhanced free radical scavenging activity of stable radical 2,2-diphenyl-1-picryl-hydrazyl (DPPH*), nitric oxide and hydroxyl radical in in vitro assay methods. The results of the study indicate that the methanolic extract of Ricinus communis root possess significant anti-inflammatory activity in acute and chronic inflammatory models in rats. The observed pharmacological activity may be due to the presence of phytochemicals like flavonoids, alkaloids and tannins present in the plant extract with various biological activities. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16310994/Anti_inflammatory_and_free_radical_scavenging_activity_of_Ricinus_communis_root_extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00692-6 DB - PRIME DP - Unbound Medicine ER -