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Multiple caffeine doses maintain vigilance during early morning operations.
Aviat Space Environ Med 2005; 76(11):1046-50AS

Abstract

INTRODUCTION

When used to counteract the effects of sleep deprivation, multiple doses of caffeine are typically ingested across an extended period of time. The goal of this study was to determine the optimal dose of caffeine for sustaining performance during sleep loss with administration of multiple doses.

METHODS

There were 48 subjects (28 men, 20 women) who were randomly assigned to 1 of 4 groups (placebo, 50, 100, or 200 mg caffeine). After an overnight 8-h sleep period, subjects were required to remain awake for the ensuing 29 h. Control data were collected until 03:00 (Day 3), followed by three 2-h test blocks. At 03:00, 05:00, and 07:00 subjects chewed two sticks of gum (Stay Alerts chewing gum) containing caffeine or placebo. Six 10-min sessions on a version of the Psychomotor Vigilance Test (PVT) were completed during each 2-h test block. The Stanford Sleepiness Scale (SSS) was administered after each PVT.

RESULTS

Lapses on the PVT were categorized as response times greater than 1, 3, or 5 s. Lapses in all categories significantly increased in the placebo group. Caffeine significantly reduced the number of lapses in a dose-related manner; and performance was maintained at baseline levels for the entire sleep loss period with multiple doses of 200 mg caffeine. There was a significant main effect for session on the SSS, the score increasing over time, but no significant differences between groups.

DISCUSSION

These results indicate that a bi-hourly administration of 200 mg of caffeine maintains vigilance performance across a single night without sleep.

Authors+Show Affiliations

Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC, USA. Gary.Kamimori@us.army.milNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16313140

Citation

Kamimori, Gary H., et al. "Multiple Caffeine Doses Maintain Vigilance During Early Morning Operations." Aviation, Space, and Environmental Medicine, vol. 76, no. 11, 2005, pp. 1046-50.
Kamimori GH, Johnson D, Thorne D, et al. Multiple caffeine doses maintain vigilance during early morning operations. Aviat Space Environ Med. 2005;76(11):1046-50.
Kamimori, G. H., Johnson, D., Thorne, D., & Belenky, G. (2005). Multiple caffeine doses maintain vigilance during early morning operations. Aviation, Space, and Environmental Medicine, 76(11), pp. 1046-50.
Kamimori GH, et al. Multiple Caffeine Doses Maintain Vigilance During Early Morning Operations. Aviat Space Environ Med. 2005;76(11):1046-50. PubMed PMID: 16313140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple caffeine doses maintain vigilance during early morning operations. AU - Kamimori,Gary H, AU - Johnson,Dagny, AU - Thorne,David, AU - Belenky,Gregory, PY - 2005/11/30/pubmed PY - 2006/2/8/medline PY - 2005/11/30/entrez SP - 1046 EP - 50 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 76 IS - 11 N2 - INTRODUCTION: When used to counteract the effects of sleep deprivation, multiple doses of caffeine are typically ingested across an extended period of time. The goal of this study was to determine the optimal dose of caffeine for sustaining performance during sleep loss with administration of multiple doses. METHODS: There were 48 subjects (28 men, 20 women) who were randomly assigned to 1 of 4 groups (placebo, 50, 100, or 200 mg caffeine). After an overnight 8-h sleep period, subjects were required to remain awake for the ensuing 29 h. Control data were collected until 03:00 (Day 3), followed by three 2-h test blocks. At 03:00, 05:00, and 07:00 subjects chewed two sticks of gum (Stay Alerts chewing gum) containing caffeine or placebo. Six 10-min sessions on a version of the Psychomotor Vigilance Test (PVT) were completed during each 2-h test block. The Stanford Sleepiness Scale (SSS) was administered after each PVT. RESULTS: Lapses on the PVT were categorized as response times greater than 1, 3, or 5 s. Lapses in all categories significantly increased in the placebo group. Caffeine significantly reduced the number of lapses in a dose-related manner; and performance was maintained at baseline levels for the entire sleep loss period with multiple doses of 200 mg caffeine. There was a significant main effect for session on the SSS, the score increasing over time, but no significant differences between groups. DISCUSSION: These results indicate that a bi-hourly administration of 200 mg of caffeine maintains vigilance performance across a single night without sleep. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/16313140/Multiple_caffeine_doses_maintain_vigilance_during_early_morning_operations_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0095-6562&volume=76&issue=11&spage=1046&aulast=Kamimori DB - PRIME DP - Unbound Medicine ER -