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Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population.
HIV Med 2006; 7(1):38-45HM

Abstract

OBJECTIVES

To establish the prevalence and quantify the severity of body fat redistribution and dyslipidaemia in HIV-infected men after long-term highly active antiretroviral therapy (HAART) compared with the background population.

METHODS

In a cross-sectional study, we included 87 HIV-infected men who had received HAART for at least 6 years and 34 HIV-negative men. Regional body composition was assessed using dual-energy X-ray absorptiometry. Fasting metabolic parameters were obtained. Associations between regional body fat distribution and metabolic parameters were evaluated.

RESULTS

HIV-infected patients and controls did not differ with regard to height and lean body mass. Compared with controls, HIV-infected men had reduced total fat mass (median 12.3 versus 19.2 kg, P<0.001), limb fat mass (4.3 versus 7.9 kg, P<0.001), and trunk fat mass (6.7 versus 10.8 kg, P<0.001) and higher trunk/limb fat ratio (1.7 versus 1.2, P<0.001). Also, patients without clinical lipodystrophy had reduced amounts of limb and trunk fat. In HIV-infected men, triglyceride levels were higher (2.0 versus 1.2 mmol/L, P<0.001), high-density lipoprotein (HDL)-cholesterol levels were lower (1.2 versus 1.3 mmol/L, P<0.05) and insulin levels were higher (40.8 versus 29.9 pmol/L, P<0.01) than in controls. All adverse metabolic parameters correlated with increased trunk/limb fat ratio, and insulin levels correlated positively with trunk fat mass (P<0.01).

CONCLUSION

Peripheral as well as central fat loss is a general characteristic of HIV-infected men after long-term HAART. Although lipoatrophy was the dominant morphological presentation, the adverse metabolic parameters were mainly associated with the increased ratio of trunk/limb fat.

Authors+Show Affiliations

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. ann-brit.e.g.hansen@rh.hosp.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16313291

Citation

Hansen, A B., et al. "Pronounced Lipoatrophy in HIV-infected Men Receiving HAART for More Than 6 Years Compared With the Background Population." HIV Medicine, vol. 7, no. 1, 2006, pp. 38-45.
Hansen AB, Lindegaard B, Obel N, et al. Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population. HIV Med. 2006;7(1):38-45.
Hansen, A. B., Lindegaard, B., Obel, N., Andersen, O., Nielsen, H., & Gerstoft, J. (2006). Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population. HIV Medicine, 7(1), pp. 38-45.
Hansen AB, et al. Pronounced Lipoatrophy in HIV-infected Men Receiving HAART for More Than 6 Years Compared With the Background Population. HIV Med. 2006;7(1):38-45. PubMed PMID: 16313291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population. AU - Hansen,A B, AU - Lindegaard,B, AU - Obel,N, AU - Andersen,O, AU - Nielsen,H, AU - Gerstoft,J, PY - 2005/11/30/pubmed PY - 2006/8/17/medline PY - 2005/11/30/entrez SP - 38 EP - 45 JF - HIV medicine JO - HIV Med. VL - 7 IS - 1 N2 - OBJECTIVES: To establish the prevalence and quantify the severity of body fat redistribution and dyslipidaemia in HIV-infected men after long-term highly active antiretroviral therapy (HAART) compared with the background population. METHODS: In a cross-sectional study, we included 87 HIV-infected men who had received HAART for at least 6 years and 34 HIV-negative men. Regional body composition was assessed using dual-energy X-ray absorptiometry. Fasting metabolic parameters were obtained. Associations between regional body fat distribution and metabolic parameters were evaluated. RESULTS: HIV-infected patients and controls did not differ with regard to height and lean body mass. Compared with controls, HIV-infected men had reduced total fat mass (median 12.3 versus 19.2 kg, P<0.001), limb fat mass (4.3 versus 7.9 kg, P<0.001), and trunk fat mass (6.7 versus 10.8 kg, P<0.001) and higher trunk/limb fat ratio (1.7 versus 1.2, P<0.001). Also, patients without clinical lipodystrophy had reduced amounts of limb and trunk fat. In HIV-infected men, triglyceride levels were higher (2.0 versus 1.2 mmol/L, P<0.001), high-density lipoprotein (HDL)-cholesterol levels were lower (1.2 versus 1.3 mmol/L, P<0.05) and insulin levels were higher (40.8 versus 29.9 pmol/L, P<0.01) than in controls. All adverse metabolic parameters correlated with increased trunk/limb fat ratio, and insulin levels correlated positively with trunk fat mass (P<0.01). CONCLUSION: Peripheral as well as central fat loss is a general characteristic of HIV-infected men after long-term HAART. Although lipoatrophy was the dominant morphological presentation, the adverse metabolic parameters were mainly associated with the increased ratio of trunk/limb fat. SN - 1464-2662 UR - https://www.unboundmedicine.com/medline/citation/16313291/Pronounced_lipoatrophy_in_HIV_infected_men_receiving_HAART_for_more_than_6_years_compared_with_the_background_population_ L2 - https://doi.org/10.1111/j.1468-1293.2005.00334.x DB - PRIME DP - Unbound Medicine ER -