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Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population.
J Intern Med. 2005 Dec; 258(6):527-35.JI

Abstract

OBJECTIVES

To examine gender-specific associations between gamma-glutamyltransferase (GGT) and incident type 2 diabetes mellitus in a representative population-based sample in Germany.

DESIGN

Prospective population-based study.

METHODS

The study was based on 1851 men and 1836 women (aged 25-64 years) who participated in the first Monitoring Trends and Determinants on Cardiovascular Diseases (MONICA) Augsburg Survey 1984/1985, and who were free of diabetes at baseline. Incident cases of type 2 diabetes were assessed using follow-up questionnaires in 1987/1988, 1997/1998 and 2002/2003 and were validated with medical records. Gender-specific hazard ratios (HRs) were estimated from Cox proportional hazard models.

RESULTS

A total of 172 cases of incident type 2 diabetes amongst men and 109 amongst women were registered during a mean follow-up period of 14.7 years. In both sexes the risk of type 2 diabetes increased with increasing levels of serum GGT. After multivariable adjustment HRs for incident type 2 diabetes across GGT categories (<25th, <50th, <75th, <87.5th and > or =87.5th percentiles) were 1.0, 1.81, 2.37, 3.41 and 4.24 (P-value for trend <0.0001) in men and 1.0, 1.42, 1.48, 1.95 and 2.41 (P-value for trend 0.0179) in women. Obesity appeared to be more strongly associated with type 2 diabetes in women with GGT equal or greater than the median compared to women with GGT below the median. However, in men the association between obesity and type 2 diabetes was almost identical in the two groups.

CONCLUSIONS

The GGT is an important predictor for incident type 2 diabetes in men and women from the general population.

Authors+Show Affiliations

Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany. christa.meisinger@gsf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16313476

Citation

Meisinger, C, et al. "Serum Gamma-glutamyltransferase and Risk of Type 2 Diabetes Mellitus in Men and Women From the General Population." Journal of Internal Medicine, vol. 258, no. 6, 2005, pp. 527-35.
Meisinger C, Löwel H, Heier M, et al. Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population. J Intern Med. 2005;258(6):527-35.
Meisinger, C., Löwel, H., Heier, M., Schneider, A., & Thorand, B. (2005). Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population. Journal of Internal Medicine, 258(6), 527-35.
Meisinger C, et al. Serum Gamma-glutamyltransferase and Risk of Type 2 Diabetes Mellitus in Men and Women From the General Population. J Intern Med. 2005;258(6):527-35. PubMed PMID: 16313476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population. AU - Meisinger,C, AU - Löwel,H, AU - Heier,M, AU - Schneider,A, AU - Thorand,B, AU - ,, PY - 2005/11/30/pubmed PY - 2005/12/28/medline PY - 2005/11/30/entrez SP - 527 EP - 35 JF - Journal of internal medicine JO - J. Intern. Med. VL - 258 IS - 6 N2 - OBJECTIVES: To examine gender-specific associations between gamma-glutamyltransferase (GGT) and incident type 2 diabetes mellitus in a representative population-based sample in Germany. DESIGN: Prospective population-based study. METHODS: The study was based on 1851 men and 1836 women (aged 25-64 years) who participated in the first Monitoring Trends and Determinants on Cardiovascular Diseases (MONICA) Augsburg Survey 1984/1985, and who were free of diabetes at baseline. Incident cases of type 2 diabetes were assessed using follow-up questionnaires in 1987/1988, 1997/1998 and 2002/2003 and were validated with medical records. Gender-specific hazard ratios (HRs) were estimated from Cox proportional hazard models. RESULTS: A total of 172 cases of incident type 2 diabetes amongst men and 109 amongst women were registered during a mean follow-up period of 14.7 years. In both sexes the risk of type 2 diabetes increased with increasing levels of serum GGT. After multivariable adjustment HRs for incident type 2 diabetes across GGT categories (<25th, <50th, <75th, <87.5th and > or =87.5th percentiles) were 1.0, 1.81, 2.37, 3.41 and 4.24 (P-value for trend <0.0001) in men and 1.0, 1.42, 1.48, 1.95 and 2.41 (P-value for trend 0.0179) in women. Obesity appeared to be more strongly associated with type 2 diabetes in women with GGT equal or greater than the median compared to women with GGT below the median. However, in men the association between obesity and type 2 diabetes was almost identical in the two groups. CONCLUSIONS: The GGT is an important predictor for incident type 2 diabetes in men and women from the general population. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/16313476/Serum_gamma_glutamyltransferase_and_risk_of_type_2_diabetes_mellitus_in_men_and_women_from_the_general_population_ L2 - https://doi.org/10.1111/j.1365-2796.2005.01572.x DB - PRIME DP - Unbound Medicine ER -