Tags

Type your tag names separated by a space and hit enter

Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study.
J Intern Med. 2005 Dec; 258(6):536-43.JI

Abstract

OBJECTIVE

Homocysteine and cardiovascular autonomic function are both predictors of cardiovascular disease and death, particularly in patients with diabetes. The mechanism by which homocysteine causes disease is unknown. The objective of our study was to determine whether hyperhomocysteinaemia is associated with impaired cardiovascular autonomic function in an age-, sex-, and glucose tolerance-stratified sample of an elderly Caucasian population.

METHODS

We studied 609 subjects, 252 with normal glucose metabolism, 173 with impaired glucose metabolism, and 184 with type 2 diabetes. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during (i) spontaneous breathing, (ii) six deep breaths over 1 min, and (iii) an active change in position from lying to standing. From these readings, 10 parameters of autonomic function were assessed (three Ewing tests, six heart rate variability tests and one test of baroreflex sensitivity). These 10 measurements were summarized in a single cardiovascular autonomic dysfunction score (CADS).

RESULTS

Comparing values of autonomic function measures in the lowest versus the highest quartile of homocysteine revealed no significant association between homocysteine level and autonomic function in the whole study group, nor in the individual glucose tolerance groups. Multiple adjustment for age, sex, waist-to-hip ratio, serum creatinine, use of antihypertensives and fasting insulin, confirmed this result. We found no evidence of effect modification of glucose tolerance status on the association between homocysteine and autonomic dysfunction (P for interaction for CADS = 0.79).

CONCLUSIONS

There is no evidence for an association between homocysteine levels and cardiovascular autonomic function in either diabetic or nondiabetic subjects. Cardiovascular autonomic dysfunction does not help explain why hyperhomocysteinaemia is related to cardiovascular mortality.

Authors+Show Affiliations

Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16313477

Citation

Spoelstra-De Man, A M E., et al. "Homocysteine Levels Are Not Associated With Cardiovascular Autonomic Function in Elderly Caucasian Subjects Without or With Type 2 Diabetes Mellitus: the Hoorn Study." Journal of Internal Medicine, vol. 258, no. 6, 2005, pp. 536-43.
Spoelstra-De Man AM, Smulders YM, Dekker JM, et al. Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study. J Intern Med. 2005;258(6):536-43.
Spoelstra-De Man, A. M., Smulders, Y. M., Dekker, J. M., Heine, R. J., Bouter, L. M., Nijpels, G., & Stehouwer, C. D. (2005). Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study. Journal of Internal Medicine, 258(6), 536-43.
Spoelstra-De Man AM, et al. Homocysteine Levels Are Not Associated With Cardiovascular Autonomic Function in Elderly Caucasian Subjects Without or With Type 2 Diabetes Mellitus: the Hoorn Study. J Intern Med. 2005;258(6):536-43. PubMed PMID: 16313477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study. AU - Spoelstra-De Man,A M E, AU - Smulders,Y M, AU - Dekker,J M, AU - Heine,R J, AU - Bouter,L M, AU - Nijpels,G, AU - Stehouwer,C D A, PY - 2005/11/30/pubmed PY - 2005/12/28/medline PY - 2005/11/30/entrez SP - 536 EP - 43 JF - Journal of internal medicine JO - J Intern Med VL - 258 IS - 6 N2 - OBJECTIVE: Homocysteine and cardiovascular autonomic function are both predictors of cardiovascular disease and death, particularly in patients with diabetes. The mechanism by which homocysteine causes disease is unknown. The objective of our study was to determine whether hyperhomocysteinaemia is associated with impaired cardiovascular autonomic function in an age-, sex-, and glucose tolerance-stratified sample of an elderly Caucasian population. METHODS: We studied 609 subjects, 252 with normal glucose metabolism, 173 with impaired glucose metabolism, and 184 with type 2 diabetes. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during (i) spontaneous breathing, (ii) six deep breaths over 1 min, and (iii) an active change in position from lying to standing. From these readings, 10 parameters of autonomic function were assessed (three Ewing tests, six heart rate variability tests and one test of baroreflex sensitivity). These 10 measurements were summarized in a single cardiovascular autonomic dysfunction score (CADS). RESULTS: Comparing values of autonomic function measures in the lowest versus the highest quartile of homocysteine revealed no significant association between homocysteine level and autonomic function in the whole study group, nor in the individual glucose tolerance groups. Multiple adjustment for age, sex, waist-to-hip ratio, serum creatinine, use of antihypertensives and fasting insulin, confirmed this result. We found no evidence of effect modification of glucose tolerance status on the association between homocysteine and autonomic dysfunction (P for interaction for CADS = 0.79). CONCLUSIONS: There is no evidence for an association between homocysteine levels and cardiovascular autonomic function in either diabetic or nondiabetic subjects. Cardiovascular autonomic dysfunction does not help explain why hyperhomocysteinaemia is related to cardiovascular mortality. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/16313477/Homocysteine_levels_are_not_associated_with_cardiovascular_autonomic_function_in_elderly_Caucasian_subjects_without_or_with_type_2_diabetes_mellitus:_the_Hoorn_Study_ L2 - https://doi.org/10.1111/j.1365-2796.2005.01578.x DB - PRIME DP - Unbound Medicine ER -