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Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study.
Trans R Soc Trop Med Hyg. 2006 Apr; 100(4):381-6.TR

Abstract

A case-control study was conducted to evaluate the efficacy of the combination of chloroquine plus proguanil as malaria prophylaxis in a non-immune population living in the Central African Republic. Cases were patients presenting with a malaria attack confirmed by a positive blood film and/or an HRP2 positive antigen test at the Pasteur Institute of Bangui. Two control subjects were included per case: one was a relative or close friend and the other was matched to the patient with respect to the length of stay. A questionnaire assessing malaria prophylaxis habits and malarial risk factors over the 2-month period prior to inclusion in the study was given to 48 cases and 96 controls. A conditional logistic regression was used to identify risk factors. The efficacy of the chloroquine plus proguanil regimen was found to be high (95.5%, 95% CI 74.0-99.2%) in this country known for high chloroquine resistance. Our data lend some support to the use of chloroquine plus proguanil in Bangui, and the protective efficacy of chloroquine plus proguanil should now be studied prospectively as part of a randomised controlled trial of various prophylactic drugs.

Authors+Show Affiliations

Epidemiology Unit, Pasteur Institute of Bangui, Central African Republic, Ambassade de France à Bangui (RCA), 75351 Paris 07 SP, France. tilendeno@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16313935

Citation

Matsika-Claquin, M D., et al. "Efficacy of Chloroquine-proguanil Malaria Prophylaxis in a Non-immune Population in Bangui, Central African Republic: a Case-control Study." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 4, 2006, pp. 381-6.
Matsika-Claquin MD, Ménard D, Fontanet AL, et al. Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study. Trans R Soc Trop Med Hyg. 2006;100(4):381-6.
Matsika-Claquin, M. D., Ménard, D., Fontanet, A. L., Ngwhotue, A., Sarda, J., & Talarmin, A. (2006). Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(4), 381-6.
Matsika-Claquin MD, et al. Efficacy of Chloroquine-proguanil Malaria Prophylaxis in a Non-immune Population in Bangui, Central African Republic: a Case-control Study. Trans R Soc Trop Med Hyg. 2006;100(4):381-6. PubMed PMID: 16313935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study. AU - Matsika-Claquin,M D, AU - Ménard,D, AU - Fontanet,A L, AU - Ngwhotue,A, AU - Sarda,J, AU - Talarmin,A, Y1 - 2005/11/28/ PY - 2004/06/23/received PY - 2005/06/28/revised PY - 2005/07/15/accepted PY - 2005/11/30/pubmed PY - 2006/7/29/medline PY - 2005/11/30/entrez SP - 381 EP - 6 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 100 IS - 4 N2 - A case-control study was conducted to evaluate the efficacy of the combination of chloroquine plus proguanil as malaria prophylaxis in a non-immune population living in the Central African Republic. Cases were patients presenting with a malaria attack confirmed by a positive blood film and/or an HRP2 positive antigen test at the Pasteur Institute of Bangui. Two control subjects were included per case: one was a relative or close friend and the other was matched to the patient with respect to the length of stay. A questionnaire assessing malaria prophylaxis habits and malarial risk factors over the 2-month period prior to inclusion in the study was given to 48 cases and 96 controls. A conditional logistic regression was used to identify risk factors. The efficacy of the chloroquine plus proguanil regimen was found to be high (95.5%, 95% CI 74.0-99.2%) in this country known for high chloroquine resistance. Our data lend some support to the use of chloroquine plus proguanil in Bangui, and the protective efficacy of chloroquine plus proguanil should now be studied prospectively as part of a randomised controlled trial of various prophylactic drugs. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/16313935/Efficacy_of_chloroquine_proguanil_malaria_prophylaxis_in_a_non_immune_population_in_Bangui_Central_African_Republic:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(05)00318-4 DB - PRIME DP - Unbound Medicine ER -