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Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics--dissolution rate implications.
Eur J Pharm Sci. 2006 Feb; 27(2-3):259-67.EJ

Abstract

The aim of this work was to simulate the fluid flow in the basket dissolution apparatus using computational fluid dynamics (CFD) and to use the resulting velocity data (in combination with velocity data from simulated flow fields of the paddle dissolution apparatus) to relate velocities in the vicinity of a dissolving surface to dissolution rate. A further objective of the work was to compare fluid velocities between the basket and paddle dissolution apparatuses. CFD simulations of the basket apparatus were carried out using Fluent software. Flow field solutions were compared with results from flow visualisation techniques and with published ultrasound-pulse-echo velocity data. Velocity data from the flow field solution revealed velocities within the basket to be of the same order as those at the base of the paddle apparatus at the same rotation speed, supporting equivalent dissolution rate data from these locations. Dissolution rates were obtained for compacts of benzoic acid dissolved in 0.1 M HCl at 37 degrees C in the basket apparatus at 50 rpm. The relationship between maximum velocity in the vicinity of a dissolving surface and dissolution rate data from both the paddle and basket apparatuses was in good agreement with theoretical predictions. Analysis of the dissolution rates suggests a significant contribution from free convection in regions of low velocity at the base of the vessel of the basket apparatus.

Authors+Show Affiliations

D'Arcy DM
School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, Dublin 2, Ireland. darcydm@tcd.ie
Corrigan OI
No affiliation info available
Healy AM
No affiliation info available

MeSH

Benzoic AcidComputer SimulationMicrofluidic Analytical TechniquesReproducibility of ResultsSoftwareSolubilityTechnology, PharmaceuticalTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16314078

Citation

D'Arcy, Deirdre M., et al. "Evaluation of Hydrodynamics in the Basket Dissolution Apparatus Using Computational Fluid Dynamics--dissolution Rate Implications." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 27, no. 2-3, 2006, pp. 259-67.
D'Arcy DM, Corrigan OI, Healy AM. Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics--dissolution rate implications. Eur J Pharm Sci. 2006;27(2-3):259-67.
D'Arcy, D. M., Corrigan, O. I., & Healy, A. M. (2006). Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics--dissolution rate implications. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 27(2-3), 259-67.
D'Arcy DM, Corrigan OI, Healy AM. Evaluation of Hydrodynamics in the Basket Dissolution Apparatus Using Computational Fluid Dynamics--dissolution Rate Implications. Eur J Pharm Sci. 2006;27(2-3):259-67. PubMed PMID: 16314078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics--dissolution rate implications. AU - D'Arcy,Deirdre M, AU - Corrigan,Owen I, AU - Healy,Anne Marie, Y1 - 2005/11/28/ PY - 2005/07/27/received PY - 2005/10/14/revised PY - 2005/10/25/accepted PY - 2005/11/30/pubmed PY - 2006/5/24/medline PY - 2005/11/30/entrez SP - 259 EP - 67 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 27 IS - 2-3 N2 - The aim of this work was to simulate the fluid flow in the basket dissolution apparatus using computational fluid dynamics (CFD) and to use the resulting velocity data (in combination with velocity data from simulated flow fields of the paddle dissolution apparatus) to relate velocities in the vicinity of a dissolving surface to dissolution rate. A further objective of the work was to compare fluid velocities between the basket and paddle dissolution apparatuses. CFD simulations of the basket apparatus were carried out using Fluent software. Flow field solutions were compared with results from flow visualisation techniques and with published ultrasound-pulse-echo velocity data. Velocity data from the flow field solution revealed velocities within the basket to be of the same order as those at the base of the paddle apparatus at the same rotation speed, supporting equivalent dissolution rate data from these locations. Dissolution rates were obtained for compacts of benzoic acid dissolved in 0.1 M HCl at 37 degrees C in the basket apparatus at 50 rpm. The relationship between maximum velocity in the vicinity of a dissolving surface and dissolution rate data from both the paddle and basket apparatuses was in good agreement with theoretical predictions. Analysis of the dissolution rates suggests a significant contribution from free convection in regions of low velocity at the base of the vessel of the basket apparatus. SN - 0928-0987 UR - https://www.unboundmedicine.com/medline/citation/16314078/Evaluation_of_hydrodynamics_in_the_basket_dissolution_apparatus_using_computational_fluid_dynamics__dissolution_rate_implications_ DB - PRIME DP - Unbound Medicine ER -