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Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD).

Abstract

Considerable clinical and experimental evidence now supports the idea that deficiencies or imbalances in certain highly unsaturated fatty acids may contribute to a range of common developmental disorders including Attention Deficit Hyperactivity Disorder (ADHD). Few intervention studies with LCPUFA supplementation have reported inconsistent and marginal results. This pilot study evaluates the effect of alpha linolenic acid (ALA)-rich nutritional supplementation in the form of flax oil and antioxidant emulsion on blood fatty acids composition and behavior in children with ADHD. Post-supplementation levels of RBC membrane fatty acids were significantly higher than pretreatment levels as well as the levels in control. There was significant improvement in the symptoms of ADHD reflected by reduction in total hyperactivity scores of ADHD children derived from ADHD rating scale.

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  • Authors+Show Affiliations

    ,

    Interdisciplinary School of Health Sciences, University of Pune, Ganeshkhind, Pune-411007, Maharashtra, India. Kalpana@unipune.ernet.in

    , , , , , , ,

    Source

    MeSH

    Ascorbic Acid
    Attention Deficit Disorder with Hyperactivity
    Child
    Dietary Supplements
    Drug Therapy, Combination
    Erythrocytes
    Fatty Acids, Essential
    Fatty Acids, Unsaturated
    Female
    Humans
    Linseed Oil
    Male
    Pilot Projects
    Thiobarbituric Acid Reactive Substances
    Treatment Outcome
    Vitamins
    alpha-Linolenic Acid

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16314082

    Citation

    Joshi, Kalpana, et al. "Supplementation With Flax Oil and Vitamin C Improves the Outcome of Attention Deficit Hyperactivity Disorder (ADHD)." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 74, no. 1, 2006, pp. 17-21.
    Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):17-21.
    Joshi, K., Lad, S., Kale, M., Patwardhan, B., Mahadik, S. P., Patni, B., ... Pandit, A. (2006). Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins, Leukotrienes, and Essential Fatty Acids, 74(1), pp. 17-21.
    Joshi K, et al. Supplementation With Flax Oil and Vitamin C Improves the Outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):17-21. PubMed PMID: 16314082.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). AU - Joshi,Kalpana, AU - Lad,Sagar, AU - Kale,Mrudula, AU - Patwardhan,Bhushan, AU - Mahadik,Sahebrao P, AU - Patni,Bindu, AU - Chaudhary,Arti, AU - Bhave,Sheila, AU - Pandit,Anand, Y1 - 2005/11/28/ PY - 2005/07/07/received PY - 2005/09/17/revised PY - 2005/10/16/accepted PY - 2005/11/30/pubmed PY - 2006/2/28/medline PY - 2005/11/30/entrez SP - 17 EP - 21 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 74 IS - 1 N2 - Considerable clinical and experimental evidence now supports the idea that deficiencies or imbalances in certain highly unsaturated fatty acids may contribute to a range of common developmental disorders including Attention Deficit Hyperactivity Disorder (ADHD). Few intervention studies with LCPUFA supplementation have reported inconsistent and marginal results. This pilot study evaluates the effect of alpha linolenic acid (ALA)-rich nutritional supplementation in the form of flax oil and antioxidant emulsion on blood fatty acids composition and behavior in children with ADHD. Post-supplementation levels of RBC membrane fatty acids were significantly higher than pretreatment levels as well as the levels in control. There was significant improvement in the symptoms of ADHD reflected by reduction in total hyperactivity scores of ADHD children derived from ADHD rating scale. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16314082/Supplementation_with_flax_oil_and_vitamin_C_improves_the_outcome_of_Attention_Deficit_Hyperactivity_Disorder__ADHD__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(05)00173-0 DB - PRIME DP - Unbound Medicine ER -