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C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.
Arch Intern Med. 2005 Nov 28; 165(21):2473-8.AI

Abstract

BACKGROUND

Determination of C-reactive protein (CRP) level has been suggested to improve cardiovascular disease (CVD) risk assessment. This study examines the utility of CRP levels to assess CVD risk in a community setting.

METHODS

We performed a prospective observational cohort study on a community population sample. A total of 1949 men and 2497 women without CVD from the Framingham Heart Study underwent CVD risk factor assessment. Initial CVD events during 8 years of follow-up were recorded.

RESULTS

There were 283 major CVD and 160 major coronary heart disease incident events. Age-, sex-, and multivariable-adjusted analyses generally used CRP level categories of less than 1, 1 to 3, and greater than 3 mg/L. In age- and sex-adjusted models, the traditional risk factors and elevated CRP levels indicated increased risk. The age- and sex-adjusted relative risk (RR) and 95% confidence interval (CI) of CRP level greater than 3 mg/L for major CVD was elevated (RR, 1.60; 95% CI, 1.19-2.14), with evidence of attenuation (RR, 1.22; 95% CI, 0.90-1.66) in multivariable models. The C statistic, a measure of the discriminatory capability of the prediction models, was 0.74 for prediction of major CVD with age and CRP level. In multivariable models that included traditional risk factors, the C statistic was 0.78, a value that was unchanged with the addition of CRP to the multivariable model. Similar relations were noted for major coronary heart disease events.

CONCLUSION

Elevated CRP level provided no further prognostic information beyond traditional office risk factor assessment to predict future major CVD and major coronary heart disease in this population sample.

Authors+Show Affiliations

General Clinical Research Center, Medical University of South Carolina, Charleston 29425, USA. wilsonpw@musc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16314543

Citation

Wilson, Peter W F., et al. "C-reactive Protein and Risk of Cardiovascular Disease in Men and Women From the Framingham Heart Study." Archives of Internal Medicine, vol. 165, no. 21, 2005, pp. 2473-8.
Wilson PW, Nam BH, Pencina M, et al. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med. 2005;165(21):2473-8.
Wilson, P. W., Nam, B. H., Pencina, M., D'Agostino, R. B., Benjamin, E. J., & O'Donnell, C. J. (2005). C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Archives of Internal Medicine, 165(21), 2473-8.
Wilson PW, et al. C-reactive Protein and Risk of Cardiovascular Disease in Men and Women From the Framingham Heart Study. Arch Intern Med. 2005 Nov 28;165(21):2473-8. PubMed PMID: 16314543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. AU - Wilson,Peter W F, AU - Nam,Byung-Ho, AU - Pencina,Michael, AU - D'Agostino,Ralph B,Sr AU - Benjamin,Emelia J, AU - O'Donnell,Christopher J, PY - 2005/11/30/pubmed PY - 2005/12/15/medline PY - 2005/11/30/entrez SP - 2473 EP - 8 JF - Archives of internal medicine JO - Arch Intern Med VL - 165 IS - 21 N2 - BACKGROUND: Determination of C-reactive protein (CRP) level has been suggested to improve cardiovascular disease (CVD) risk assessment. This study examines the utility of CRP levels to assess CVD risk in a community setting. METHODS: We performed a prospective observational cohort study on a community population sample. A total of 1949 men and 2497 women without CVD from the Framingham Heart Study underwent CVD risk factor assessment. Initial CVD events during 8 years of follow-up were recorded. RESULTS: There were 283 major CVD and 160 major coronary heart disease incident events. Age-, sex-, and multivariable-adjusted analyses generally used CRP level categories of less than 1, 1 to 3, and greater than 3 mg/L. In age- and sex-adjusted models, the traditional risk factors and elevated CRP levels indicated increased risk. The age- and sex-adjusted relative risk (RR) and 95% confidence interval (CI) of CRP level greater than 3 mg/L for major CVD was elevated (RR, 1.60; 95% CI, 1.19-2.14), with evidence of attenuation (RR, 1.22; 95% CI, 0.90-1.66) in multivariable models. The C statistic, a measure of the discriminatory capability of the prediction models, was 0.74 for prediction of major CVD with age and CRP level. In multivariable models that included traditional risk factors, the C statistic was 0.78, a value that was unchanged with the addition of CRP to the multivariable model. Similar relations were noted for major coronary heart disease events. CONCLUSION: Elevated CRP level provided no further prognostic information beyond traditional office risk factor assessment to predict future major CVD and major coronary heart disease in this population sample. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16314543/C_reactive_protein_and_risk_of_cardiovascular_disease_in_men_and_women_from_the_Framingham_Heart_Study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.165.21.2473 DB - PRIME DP - Unbound Medicine ER -