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[Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity].
Rev Invest Clin. 2005 Jul-Aug; 57(4):505-12.RI

Abstract

The non-alcoholic steato-hepatitis (NASH) is a common disorder in obese, type 2 diabetics, female and patients with dislipidaemia. Hepatic biochemical test are abnormal. Despite the lack of its own morphological characteristics, NASH can be differentiated from other pathologies, the gold standard for diagnosis is liver biopsy.

MATERIAL AND METHODS

We designed a retrolective, comparative, observational and cross-sectional study. Thirty-five obese subjects (11 men and 24 women) who underwent to bariatric surgery and liuer biopsy were included. Data were taken from clinical files, such as anthropometric and biochemical test. Those who had clinical history of related alcohol ingestion or liver damage related to drugs were excluded. A experimented pathologist classified the biopsies according to Brunt classification. Liver slides were classified according to 1) presence of NASH; 2) Inflammation and 3) Fibrosis. Differences between groups were analysed by ANOVA and Spearman correlation.

RESULTS

We found differences between women (w) and men (m) for height (m: 1.71 +/- 0.9 vs. w:1.60 +/- 0.09m); weight (m:172.5 +/- 39.1 vs. w:126.9 +/- 24.1kg) and BMI (m:58.2 +/- 9.8 vs. w:49.8 +/- 9) , but not for NASH frequency. Nevertheless subjects with NASH (n = 29, 82.8%o) were older than those without NASH (38.3 +/- 9.6 vs. 29.5 +/- 5.2) and had higher aminotrasferases serum levels (AST: 33.1 +/- 19.2 vs. 23.7 +/- 6.3 ULIL; ALT: 36.5 +/- 19.8 vs. 20.3 +/- 7.6ULIL). NASH pa- tients and those with higher grade of histological inflammation had increment of transaminases and albumin levels. Fibrosis showed correlation only with AST (p = 0.020) and ALT (p = 0.002).

CONCLUSION

The NASH frequency in patients who underwent to bariatric surgery for weight reduction is very high (82.8%) and exists correlation among liver test and histological findings but not with clinical because the clinical diagnosis is complicated.

Authors+Show Affiliations

Clínica de Obesidad del Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

16315634

Citation

Chavarría-Arciniega, Sonia, et al. "[Relationship Between Morphological Diagnosis of NASH (non-alcoholic Steatohepatitis) and Liver Function Tests in a Group of Patients With Morbid Obesity]." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 57, no. 4, 2005, pp. 505-12.
Chavarría-Arciniega S, López-Alvarenga JC, Uribe-Uribe NO, et al. [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]. Rev Invest Clin. 2005;57(4):505-12.
Chavarría-Arciniega, S., López-Alvarenga, J. C., Uribe-Uribe, N. O., Herrera-Hernández, M., & González-Barranco, J. (2005). [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 57(4), 505-12.
Chavarría-Arciniega S, et al. [Relationship Between Morphological Diagnosis of NASH (non-alcoholic Steatohepatitis) and Liver Function Tests in a Group of Patients With Morbid Obesity]. Rev Invest Clin. 2005 Jul-Aug;57(4):505-12. PubMed PMID: 16315634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]. AU - Chavarría-Arciniega,Sonia, AU - López-Alvarenga,Juan Carlos, AU - Uribe-Uribe,Norma Ofelia, AU - Herrera-Hernández,Miguel, AU - González-Barranco,Jorge, PY - 2005/12/1/pubmed PY - 2006/3/24/medline PY - 2005/12/1/entrez SP - 505 EP - 12 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev. Invest. Clin. VL - 57 IS - 4 N2 - UNLABELLED: The non-alcoholic steato-hepatitis (NASH) is a common disorder in obese, type 2 diabetics, female and patients with dislipidaemia. Hepatic biochemical test are abnormal. Despite the lack of its own morphological characteristics, NASH can be differentiated from other pathologies, the gold standard for diagnosis is liver biopsy. MATERIAL AND METHODS: We designed a retrolective, comparative, observational and cross-sectional study. Thirty-five obese subjects (11 men and 24 women) who underwent to bariatric surgery and liuer biopsy were included. Data were taken from clinical files, such as anthropometric and biochemical test. Those who had clinical history of related alcohol ingestion or liver damage related to drugs were excluded. A experimented pathologist classified the biopsies according to Brunt classification. Liver slides were classified according to 1) presence of NASH; 2) Inflammation and 3) Fibrosis. Differences between groups were analysed by ANOVA and Spearman correlation. RESULTS: We found differences between women (w) and men (m) for height (m: 1.71 +/- 0.9 vs. w:1.60 +/- 0.09m); weight (m:172.5 +/- 39.1 vs. w:126.9 +/- 24.1kg) and BMI (m:58.2 +/- 9.8 vs. w:49.8 +/- 9) , but not for NASH frequency. Nevertheless subjects with NASH (n = 29, 82.8%o) were older than those without NASH (38.3 +/- 9.6 vs. 29.5 +/- 5.2) and had higher aminotrasferases serum levels (AST: 33.1 +/- 19.2 vs. 23.7 +/- 6.3 ULIL; ALT: 36.5 +/- 19.8 vs. 20.3 +/- 7.6ULIL). NASH pa- tients and those with higher grade of histological inflammation had increment of transaminases and albumin levels. Fibrosis showed correlation only with AST (p = 0.020) and ALT (p = 0.002). CONCLUSION: The NASH frequency in patients who underwent to bariatric surgery for weight reduction is very high (82.8%) and exists correlation among liver test and histological findings but not with clinical because the clinical diagnosis is complicated. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/16315634/[Relationship_between_morphological_diagnosis_of_NASH__non_alcoholic_steatohepatitis__and_liver_function_tests_in_a_group_of_patients_with_morbid_obesity]_ L2 - http://www.diseaseinfosearch.org/result/5243 DB - PRIME DP - Unbound Medicine ER -