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[What will be the proper criteria for impaired fasting glucose for Korean men? Based on medical screening data from a general hospital].
J Prev Med Public Health. 2005 May; 38(2):203-7.JP

Abstract

OBJECTIVES

Recently, the American Diabetes Association (ADA) redefined the criteria of prediabetes, which has lowered the diagnostic level of fasting plasma glucose (FPG) from 110 to 125 mg/dl, down to levels between 100 to 125mg/dl. The purpose of this study was to determine the predictive cutoff level of FPG as a risk for the development of diabetes mellitus in Korean men.

METHODS

A retrospective cohort study was conducted on 11,423 (64.5%) out of 17,696 males < or =30 years of age, and who met the FPG of < or = 125 mg/dl and hemoglobin A1c of < or = 6.4% criteria, without a history of diabetes, and who were enrolled at the screening center of a certain university hospital between January and December 1999. The subjects were followed from January 1999 to December 2002 (mean follow-up duration; 2.3(+/-0.7) years). They were classified as normal (FPG <100mg/dl), high glucose (FPG > or =100 mg/dl and < 110 mg/dl) and impaired fasting glucose (FPG 2110 mg/dl and < 125 mg/dl) on the basis of their fasting plasma glucose level measured in 1999. We compared the incidence of diabetes between the 3 groups by performing Cox proportional hazards model and used receiver operating characteristic analyses of the FPG level, in order to estimate the optimal cut-off values as predictors of incident diabetes.

RESULTS

At the baseline, most of the study subjects were in age in their 30s to 40s (mean age, 41.8(+/-7.1) year). The incidence of diabetes mellitus in this study was 1.19 per 1,000 person-years (95% CI=0.68-1.79), which was much lower than the results of a community-based study that was 5.01 per 1,000 person-years. The relative risks of incident diabetes in the high glucose and impaired fasting glucose groups, compared with the normal glucose group, were 10.3 (95% CI=2.58-41.2) and 95.2 (95% CI= 29.3-309.1), respectively. After adjustment for age, body mass index, and log triglyceride, a FPG greater than 100 mg/dl remained significant predictors of incident diabetes. Using the receiver operating characteristic (ROC) curve, the optimal cutoff level of FPG as a predictor of incident diabetes was 97.5 mg/dl, with a sensitivity and a specificity of 81.0% and 86.0%, respectively.

CONCLUSION

These results suggest that lowering the criteria of impaired fasting glucose is needed in Korean male adults. Future studies on community-based populations, including women, will be required to determine the optimal cutoff level of FPG as a predictor of incident diabetes.

Authors+Show Affiliations

Department of Occupational Medicine, Kangbuk Samsung Hospital & Sungkyunkwan University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

kor

PubMed ID

16315759

Citation

Ryu, Seungho, et al. "[What Will Be the Proper Criteria for Impaired Fasting Glucose for Korean Men? Based On Medical Screening Data From a General Hospital]." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 38, no. 2, 2005, pp. 203-7.
Ryu S, Chang YS, Kim DI, et al. [What will be the proper criteria for impaired fasting glucose for Korean men? Based on medical screening data from a general hospital]. J Prev Med Public Health. 2005;38(2):203-7.
Ryu, S., Chang, Y. S., Kim, D. I., Suh, B. S., & Kim, W. S. (2005). [What will be the proper criteria for impaired fasting glucose for Korean men? Based on medical screening data from a general hospital]. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 38(2), 203-7.
Ryu S, et al. [What Will Be the Proper Criteria for Impaired Fasting Glucose for Korean Men? Based On Medical Screening Data From a General Hospital]. J Prev Med Public Health. 2005;38(2):203-7. PubMed PMID: 16315759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [What will be the proper criteria for impaired fasting glucose for Korean men? Based on medical screening data from a general hospital]. AU - Ryu,Seungho, AU - Chang,Yoo-Soo, AU - Kim,Dong-Il, AU - Suh,Byung-Seong, AU - Kim,Woon Sool, PY - 2005/12/1/pubmed PY - 2005/12/24/medline PY - 2005/12/1/entrez SP - 203 EP - 7 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 38 IS - 2 N2 - OBJECTIVES: Recently, the American Diabetes Association (ADA) redefined the criteria of prediabetes, which has lowered the diagnostic level of fasting plasma glucose (FPG) from 110 to 125 mg/dl, down to levels between 100 to 125mg/dl. The purpose of this study was to determine the predictive cutoff level of FPG as a risk for the development of diabetes mellitus in Korean men. METHODS: A retrospective cohort study was conducted on 11,423 (64.5%) out of 17,696 males < or =30 years of age, and who met the FPG of < or = 125 mg/dl and hemoglobin A1c of < or = 6.4% criteria, without a history of diabetes, and who were enrolled at the screening center of a certain university hospital between January and December 1999. The subjects were followed from January 1999 to December 2002 (mean follow-up duration; 2.3(+/-0.7) years). They were classified as normal (FPG <100mg/dl), high glucose (FPG > or =100 mg/dl and < 110 mg/dl) and impaired fasting glucose (FPG 2110 mg/dl and < 125 mg/dl) on the basis of their fasting plasma glucose level measured in 1999. We compared the incidence of diabetes between the 3 groups by performing Cox proportional hazards model and used receiver operating characteristic analyses of the FPG level, in order to estimate the optimal cut-off values as predictors of incident diabetes. RESULTS: At the baseline, most of the study subjects were in age in their 30s to 40s (mean age, 41.8(+/-7.1) year). The incidence of diabetes mellitus in this study was 1.19 per 1,000 person-years (95% CI=0.68-1.79), which was much lower than the results of a community-based study that was 5.01 per 1,000 person-years. The relative risks of incident diabetes in the high glucose and impaired fasting glucose groups, compared with the normal glucose group, were 10.3 (95% CI=2.58-41.2) and 95.2 (95% CI= 29.3-309.1), respectively. After adjustment for age, body mass index, and log triglyceride, a FPG greater than 100 mg/dl remained significant predictors of incident diabetes. Using the receiver operating characteristic (ROC) curve, the optimal cutoff level of FPG as a predictor of incident diabetes was 97.5 mg/dl, with a sensitivity and a specificity of 81.0% and 86.0%, respectively. CONCLUSION: These results suggest that lowering the criteria of impaired fasting glucose is needed in Korean male adults. Future studies on community-based populations, including women, will be required to determine the optimal cutoff level of FPG as a predictor of incident diabetes. SN - 1975-8375 UR - https://www.unboundmedicine.com/medline/citation/16315759/[What_will_be_the_proper_criteria_for_impaired_fasting_glucose_for_Korean_men_Based_on_medical_screening_data_from_a_general_hospital]_ L2 - http://jpmph.org/journal/view.php?year=2005&amp;vol=38&amp;page=203 DB - PRIME DP - Unbound Medicine ER -