Tags

Type your tag names separated by a space and hit enter

Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic?

Abstract

OBJECTIVE

The aim of the present study is to evaluate sub-groups of PCOS patients who will benefit from metformin therapy and to find out any predictors of ovulation in PCOS sub-groups.

METHOD

In the current prospective-randomized, placebo-controlled, double-blind study, PCOS patients (n = 116) were divided into six main groups according to glucose to insulin ratio (G-I ratio mg/10(-4) U) and body mass index (BMI kg/m2) as: Group 1: normoinsulinemic (G-I ratio > or = 4.5 mg/10(-4) U), lean (BMI < 25) (n = 37); Group 2: normoinsulinemic, overweight (BMI: 25-29.9) (n = 19); Group 3: normoinsulinemic, obese (BMI > or = 30) (n = 18); Group 4: hyperinsulinemic (G-I ratio < 4.5 mg/10(-4) U), lean (n = 28); Group 5: hyperinsulinemic, overweight (n = 17); Group 6: hyperinsulinemic, obese (n = 20). Patients in each group were randomized onto placebo or metformin treatments (850 mg two to three times per day according to BMI). The rate of ovulation, biochemical profile, hormonal profile and clinical symptoms of hyperandrogenism were evaluated before and after 6 months of metformin and placebo treatments.

RESULT(S)

We observed a significant decrease in WHR following metformin therapy in the normoinsulinemic overweight sub-group (P < 0.05). The duration of the menstrual cycle significantly decreased in the normoinsulinemic obese sub-group on metformin therapy (P < 0.05). Metformin had a significant effect on hirsutism scores in hyperinsulinemic lean women (P < 0.05) and decreased DHEAS levels significantly in the lean hyperinsulinemic and normoinsulinemic groups (P < 0.05). Metformin had significant effects on ovulation in only lean hyperinsulinemic women (P < 0.05).

CONCLUSIONS

Clinical outcomes of metformin therapy may be categorized on the basis of basal BMI and insulin levels in PCOS patients.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centrum Clinic, IVF Division, Nenehatun, No: 59 GOP, Ankara 06700, Turkey. gogsenonalan@yahoo.com

    , , , ,

    Source

    MeSH

    Adiposity
    Adult
    Blood Glucose
    Body Mass Index
    Double-Blind Method
    Female
    Humans
    Hyperinsulinism
    Hypoglycemic Agents
    Insulin
    Metformin
    Obesity
    Polycystic Ovary Syndrome
    Predictive Value of Tests
    Prospective Studies
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16316811

    Citation

    Onalan, Gogsen, et al. "Predictive Value of Glucose-insulin Ratio in PCOS and Profile of Women Who Will Benefit From Metformin Therapy: Obese, Lean, Hyper or Normoinsulinemic?" European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 123, no. 2, 2005, pp. 204-11.
    Onalan G, Goktolga U, Ceyhan T, et al. Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic? Eur J Obstet Gynecol Reprod Biol. 2005;123(2):204-11.
    Onalan, G., Goktolga, U., Ceyhan, T., Bagis, T., Onalan, R., & Pabuçcu, R. (2005). Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 123(2), pp. 204-11.
    Onalan G, et al. Predictive Value of Glucose-insulin Ratio in PCOS and Profile of Women Who Will Benefit From Metformin Therapy: Obese, Lean, Hyper or Normoinsulinemic. Eur J Obstet Gynecol Reprod Biol. 2005 Dec 1;123(2):204-11. PubMed PMID: 16316811.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic? AU - Onalan,Gogsen, AU - Goktolga,Umit, AU - Ceyhan,Temel, AU - Bagis,Tayfun, AU - Onalan,Reside, AU - Pabuçcu,Recai, PY - 2004/08/16/received PY - 2005/04/13/revised PY - 2005/05/17/accepted PY - 2005/12/1/pubmed PY - 2006/3/22/medline PY - 2005/12/1/entrez SP - 204 EP - 11 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 123 IS - 2 N2 - OBJECTIVE: The aim of the present study is to evaluate sub-groups of PCOS patients who will benefit from metformin therapy and to find out any predictors of ovulation in PCOS sub-groups. METHOD: In the current prospective-randomized, placebo-controlled, double-blind study, PCOS patients (n = 116) were divided into six main groups according to glucose to insulin ratio (G-I ratio mg/10(-4) U) and body mass index (BMI kg/m2) as: Group 1: normoinsulinemic (G-I ratio > or = 4.5 mg/10(-4) U), lean (BMI < 25) (n = 37); Group 2: normoinsulinemic, overweight (BMI: 25-29.9) (n = 19); Group 3: normoinsulinemic, obese (BMI > or = 30) (n = 18); Group 4: hyperinsulinemic (G-I ratio < 4.5 mg/10(-4) U), lean (n = 28); Group 5: hyperinsulinemic, overweight (n = 17); Group 6: hyperinsulinemic, obese (n = 20). Patients in each group were randomized onto placebo or metformin treatments (850 mg two to three times per day according to BMI). The rate of ovulation, biochemical profile, hormonal profile and clinical symptoms of hyperandrogenism were evaluated before and after 6 months of metformin and placebo treatments. RESULT(S): We observed a significant decrease in WHR following metformin therapy in the normoinsulinemic overweight sub-group (P < 0.05). The duration of the menstrual cycle significantly decreased in the normoinsulinemic obese sub-group on metformin therapy (P < 0.05). Metformin had a significant effect on hirsutism scores in hyperinsulinemic lean women (P < 0.05) and decreased DHEAS levels significantly in the lean hyperinsulinemic and normoinsulinemic groups (P < 0.05). Metformin had significant effects on ovulation in only lean hyperinsulinemic women (P < 0.05). CONCLUSIONS: Clinical outcomes of metformin therapy may be categorized on the basis of basal BMI and insulin levels in PCOS patients. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/16316811/Predictive_value_of_glucose_insulin_ratio_in_PCOS_and_profile_of_women_who_will_benefit_from_metformin_therapy:_obese_lean_hyper_or_normoinsulinemic L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(05)00233-2 DB - PRIME DP - Unbound Medicine ER -