Tags

Type your tag names separated by a space and hit enter

[Nasopharyngeal carcinoma in Tunisian children: retrospective epidemiological, clinical and biological study about 48 cases].
Bull Cancer 2005; 92(11):977-81BC

Abstract

OBJECTIVE

Report epidemiological, clinical and biological aspects of nasopharyngeal carcinoma in Tunisian children.

PATIENTS AND METHODS

Our retrospective study from 1994 to 2001 included all children treated for nasopharyngeal carcinoma in the Salah Azaïz Cancer Institute of Tunis. Initial investigation consisted of ENT and general examination, nasopharyngeal CT-scan, abdominal echography, chest X-ray and bone scintigraphy. Biological markers included blood-count, erythrocytes sedimentation and serum lactic dehydrogenase. All children received neoadjuvant chemotherapy (adriamycin, cisplatin) and irradiation therapy.

RESULTS

There were 48 children with a median age of 13,7 years and a sex ratio of 1,4 (28/20). Lesions are staged T2, T3 and T4 in 2,1 %, 18,7% and 79,2% of cases. All patients have cervical palpable nodes at diagnosis classified as N1 (8,3%), N2 (33.3%) and N3 (58.3%). A significant correlation was found between serum lactic dehydrogenase and the N stage (p = 0.02). After follow up, recurrence of disease was noted for three children, persistent disease for two children and metastatic disease in five cases. The overall and relapse free survival at 5 years were 79.1% and 68.9% respectively. Patients aged 13 or lower had poorer 5 overall survival rate (72.3%) than older age group (84.2%).

Authors+Show Affiliations

Service de biologie clinique, Institut Salah Azaïz, boulevard du 9 avril, 1006 Bab Saâdoun, Tunis, Tunisie. aouatef.enneifer@rns.tnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

16316831

Citation

Jmal, Aouatef, et al. "[Nasopharyngeal Carcinoma in Tunisian Children: Retrospective Epidemiological, Clinical and Biological Study About 48 Cases]." Bulletin Du Cancer, vol. 92, no. 11, 2005, pp. 977-81.
Jmal A, Boussen H, Ghanem A, et al. [Nasopharyngeal carcinoma in Tunisian children: retrospective epidemiological, clinical and biological study about 48 cases]. Bull Cancer. 2005;92(11):977-81.
Jmal, A., Boussen, H., Ghanem, A., Abaza, H., Gara, S., Douik, H., ... Guemira, F. (2005). [Nasopharyngeal carcinoma in Tunisian children: retrospective epidemiological, clinical and biological study about 48 cases]. Bulletin Du Cancer, 92(11), pp. 977-81.
Jmal A, et al. [Nasopharyngeal Carcinoma in Tunisian Children: Retrospective Epidemiological, Clinical and Biological Study About 48 Cases]. Bull Cancer. 2005;92(11):977-81. PubMed PMID: 16316831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nasopharyngeal carcinoma in Tunisian children: retrospective epidemiological, clinical and biological study about 48 cases]. AU - Jmal,Aouatef, AU - Boussen,Hammouda, AU - Ghanem,Abderraouf, AU - Abaza,Hajer, AU - Gara,Sonia, AU - Douik,Hayet, AU - Harzallah,Latifa, AU - Benna,Farouk, AU - Ladgham,Abderrahmen, AU - Guemira,Fethi, PY - 2005/02/01/received PY - 2005/08/30/accepted PY - 2005/12/1/pubmed PY - 2006/1/6/medline PY - 2005/12/1/entrez SP - 977 EP - 81 JF - Bulletin du cancer JO - Bull Cancer VL - 92 IS - 11 N2 - OBJECTIVE: Report epidemiological, clinical and biological aspects of nasopharyngeal carcinoma in Tunisian children. PATIENTS AND METHODS: Our retrospective study from 1994 to 2001 included all children treated for nasopharyngeal carcinoma in the Salah Azaïz Cancer Institute of Tunis. Initial investigation consisted of ENT and general examination, nasopharyngeal CT-scan, abdominal echography, chest X-ray and bone scintigraphy. Biological markers included blood-count, erythrocytes sedimentation and serum lactic dehydrogenase. All children received neoadjuvant chemotherapy (adriamycin, cisplatin) and irradiation therapy. RESULTS: There were 48 children with a median age of 13,7 years and a sex ratio of 1,4 (28/20). Lesions are staged T2, T3 and T4 in 2,1 %, 18,7% and 79,2% of cases. All patients have cervical palpable nodes at diagnosis classified as N1 (8,3%), N2 (33.3%) and N3 (58.3%). A significant correlation was found between serum lactic dehydrogenase and the N stage (p = 0.02). After follow up, recurrence of disease was noted for three children, persistent disease for two children and metastatic disease in five cases. The overall and relapse free survival at 5 years were 79.1% and 68.9% respectively. Patients aged 13 or lower had poorer 5 overall survival rate (72.3%) than older age group (84.2%). SN - 1769-6917 UR - https://www.unboundmedicine.com/medline/citation/16316831/[Nasopharyngeal_carcinoma_in_Tunisian_children:_retrospective_epidemiological_clinical_and_biological_study_about_48_cases]_ L2 - http://www.jle.com/medline.md?issn=0007-4551&vol=92&iss=11&page=977 DB - PRIME DP - Unbound Medicine ER -