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Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium.
Scand J Clin Lab Invest 2005; 65(8):659-70SJ

Abstract

OBJECTIVE

Prior studies have been equivocal about the efficacy of magnesium therapy in acute asthma exacerbations. We hypothesize that pretreatment ionized magnesium (Mg(2+)) levels and/or the ratio of ionized calcium to ionized magnesium (Ca(2+)/Mg(2+)) may have been confounding variables in these previous studies. Here, we report on the incidence of abnormal divalent ion levels in our asthma population.

MATERIAL AND METHODS

The study was designed as a randomized, double-blind, placebo-controlled trial of intravenous magnesium. Inclusion criteria were: age >18 years, percentage predicted forced expiratory volume (FEV(1)) <75 % after an initial beta-agonist. African-American patients (AA) at an urban university hospital were randomized to 2 g IV Mg or placebo. Mg(2+) and Ca(2+)/Mg(2+) levels were measured pre- and post-infusion. Data were reported as means+/-SD. Student's t-test and Fisher's exact test were used where appropriate (alpha = 0.05, two tailed).

RESULTS

Fifty-five AA patients (mean age of 42.7 years+/-15.6 years, range 18-75 years) were studied. A significantly (p<0.05) lower level of Mg(2+) was found in asthma (AS) patients compared with that in the AA group, by 0.03 mmol/L (95 % CI, 0.007-0.053 mmol/L). The AS group had a mean increase in Ca(2+)/Mg(2+) ratios over the AA group, of 0.27 (95 % CI, 0.16-0.38); 100 % of patients with abnormal divalent ion levels were corrected with IV magnesium.

CONCLUSIONS

We identified a subgroup of asthmatic patients with significant abnormalities in their divalent ion concentrations, which was corrected with IV magnesium.

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    Authors+Show Affiliations

    Sinert R
    Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA. nephron1@bellatlantic.net
    Spektor M
    No affiliation info available
    Gorlin A
    No affiliation info available
    Doty C
    No affiliation info available
    Rubin A
    No affiliation info available
    Altura BT
    No affiliation info available
    Altura BM
    No affiliation info available

    MeSH

    AdolescentAdultAgedAsthmaCalciumFemaleHumansIonsMagnesiumMaleMiddle Aged

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16319040

    Citation

    Sinert, R, et al. "Ionized Magnesium Levels and the Ratio of Ionized Calcium to Magnesium in Asthma Patients Before and After Treatment With Magnesium." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 65, no. 8, 2005, pp. 659-70.
    Sinert R, Spektor M, Gorlin A, et al. Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium. Scand J Clin Lab Invest. 2005;65(8):659-70.
    Sinert, R., Spektor, M., Gorlin, A., Doty, C., Rubin, A., Altura, B. T., & Altura, B. M. (2005). Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium. Scandinavian Journal of Clinical and Laboratory Investigation, 65(8), pp. 659-70.
    Sinert R, et al. Ionized Magnesium Levels and the Ratio of Ionized Calcium to Magnesium in Asthma Patients Before and After Treatment With Magnesium. Scand J Clin Lab Invest. 2005;65(8):659-70. PubMed PMID: 16319040.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium. AU - Sinert,R, AU - Spektor,M, AU - Gorlin,A, AU - Doty,C, AU - Rubin,A, AU - Altura,B T, AU - Altura,B M, PY - 2005/12/2/pubmed PY - 2006/3/8/medline PY - 2005/12/2/entrez SP - 659 EP - 70 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 65 IS - 8 N2 - OBJECTIVE: Prior studies have been equivocal about the efficacy of magnesium therapy in acute asthma exacerbations. We hypothesize that pretreatment ionized magnesium (Mg(2+)) levels and/or the ratio of ionized calcium to ionized magnesium (Ca(2+)/Mg(2+)) may have been confounding variables in these previous studies. Here, we report on the incidence of abnormal divalent ion levels in our asthma population. MATERIAL AND METHODS: The study was designed as a randomized, double-blind, placebo-controlled trial of intravenous magnesium. Inclusion criteria were: age >18 years, percentage predicted forced expiratory volume (FEV(1)) <75 % after an initial beta-agonist. African-American patients (AA) at an urban university hospital were randomized to 2 g IV Mg or placebo. Mg(2+) and Ca(2+)/Mg(2+) levels were measured pre- and post-infusion. Data were reported as means+/-SD. Student's t-test and Fisher's exact test were used where appropriate (alpha = 0.05, two tailed). RESULTS: Fifty-five AA patients (mean age of 42.7 years+/-15.6 years, range 18-75 years) were studied. A significantly (p<0.05) lower level of Mg(2+) was found in asthma (AS) patients compared with that in the AA group, by 0.03 mmol/L (95 % CI, 0.007-0.053 mmol/L). The AS group had a mean increase in Ca(2+)/Mg(2+) ratios over the AA group, of 0.27 (95 % CI, 0.16-0.38); 100 % of patients with abnormal divalent ion levels were corrected with IV magnesium. CONCLUSIONS: We identified a subgroup of asthmatic patients with significant abnormalities in their divalent ion concentrations, which was corrected with IV magnesium. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/16319040/Ionized_magnesium_levels_and_the_ratio_of_ionized_calcium_to_magnesium_in_asthma_patients_before_and_after_treatment_with_magnesium_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510500333825 DB - PRIME DP - Unbound Medicine ER -