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Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies.
J Antimicrob Chemother. 2006 Feb; 57(2):294-300.JA

Abstract

OBJECTIVES

To determine the effects of albendazole on rabbits infected with larvae of Angiostrongylus cantonensis by histopathological and magnetic resonance imaging (MRI) techniques.

METHODS

Male rabbits were infected with 400 A. cantonensis larvae and treated with albendazole (5 mg/kg/day) for 2-14 days on day 5, 10, 15 or 20 post-infection.

RESULTS

Although there were pathological changes in the brains, MRI revealed unremarkable findings in the untreated group. However, the treated rabbits exhibited eosinophilic meningitis, choroid plexus inflammation, meningeal congestion, encephalitis, perivascular cuffing and meningitis, and were also found to have abnormal signal intensities on brain MR images in the 20 day post-infection treated group.

CONCLUSIONS

Pathological changes in the brains of the treated rabbits are more severe than those without albendazole treatment, suggesting that the drug may not be very suitable for the treatment of cerebral angiostrongyliasis.

Authors+Show Affiliations

Department of Parasitology, College of Medicine, Chang-Gung University, and Department of Pathology, Chang-Gung Memorial Hospital, Kueisan, Taoyuan 333, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16319180

Citation

Wang, Lian-Chen, et al. "Pathological Changes in the Brains of Rabbits Experimentally Infected With Angiostrongylus Cantonensis After Albendazole Treatment: Histopathological and Magnetic Resonance Imaging Studies." The Journal of Antimicrobial Chemotherapy, vol. 57, no. 2, 2006, pp. 294-300.
Wang LC, Jung SM, Chen CC, et al. Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies. J Antimicrob Chemother. 2006;57(2):294-300.
Wang, L. C., Jung, S. M., Chen, C. C., Wong, H. F., Wan, D. P., & Wan, Y. L. (2006). Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies. The Journal of Antimicrobial Chemotherapy, 57(2), 294-300.
Wang LC, et al. Pathological Changes in the Brains of Rabbits Experimentally Infected With Angiostrongylus Cantonensis After Albendazole Treatment: Histopathological and Magnetic Resonance Imaging Studies. J Antimicrob Chemother. 2006;57(2):294-300. PubMed PMID: 16319180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies. AU - Wang,Lian-Chen, AU - Jung,Shih-Ming, AU - Chen,Chien-Chuan, AU - Wong,Ho-Fai, AU - Wan,Dinah-Pingni, AU - Wan,Yung-Liang, Y1 - 2005/11/30/ PY - 2005/12/2/pubmed PY - 2006/3/22/medline PY - 2005/12/2/entrez SP - 294 EP - 300 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 57 IS - 2 N2 - OBJECTIVES: To determine the effects of albendazole on rabbits infected with larvae of Angiostrongylus cantonensis by histopathological and magnetic resonance imaging (MRI) techniques. METHODS: Male rabbits were infected with 400 A. cantonensis larvae and treated with albendazole (5 mg/kg/day) for 2-14 days on day 5, 10, 15 or 20 post-infection. RESULTS: Although there were pathological changes in the brains, MRI revealed unremarkable findings in the untreated group. However, the treated rabbits exhibited eosinophilic meningitis, choroid plexus inflammation, meningeal congestion, encephalitis, perivascular cuffing and meningitis, and were also found to have abnormal signal intensities on brain MR images in the 20 day post-infection treated group. CONCLUSIONS: Pathological changes in the brains of the treated rabbits are more severe than those without albendazole treatment, suggesting that the drug may not be very suitable for the treatment of cerebral angiostrongyliasis. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/16319180/Pathological_changes_in_the_brains_of_rabbits_experimentally_infected_with_Angiostrongylus_cantonensis_after_albendazole_treatment:_histopathological_and_magnetic_resonance_imaging_studies_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dki430 DB - PRIME DP - Unbound Medicine ER -