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Magnesium intake and reduced risk of colon cancer in a prospective study of women.
Am J Epidemiol 2006; 163(3):232-5AJ

Abstract

A recent prospective study among Swedish women suggested an inverse association of dietary magnesium intake with incidence of colorectal cancer. The authors assessed this association in a cohort of 35,196 Iowa women initially free of cancer and aged 55-69 years in 1986. Intakes of magnesium and other nutrients were assessed by food frequency questionnaire at baseline. Over 17 years of follow-up through 2002, 1,112 women developed colorectal cancer. After adjustment for age, energy, other nutrients, and risk factors for colorectal cancer, the hazard ratios of colorectal cancer across quintiles of magnesium intake were 1.00, 0.96, 0.83, 0.87, and 0.80 (95% confidence interval: 0.62, 1.03; p(trend) = 0.06). The association was largely absent for rectal cancer but, for colon cancer, the hazard ratios were 1.00, 1.00, 0.88, 0.85, and 0.77 (95% confidence interval: 0.58, 1.03; p(trend) = 0.04). These findings offer further evidence that a diet high in magnesium may reduce the occurrence of colon cancer among women. If replicated by other observational studies, a clinical trial would be needed to determine whether it is magnesium, specifically, and not other aspects of the contributing foods, that may offer benefit.

Authors+Show Affiliations

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. folsom@epi.umn.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16319289

Citation

Folsom, Aaron R., and Ching-Ping Hong. "Magnesium Intake and Reduced Risk of Colon Cancer in a Prospective Study of Women." American Journal of Epidemiology, vol. 163, no. 3, 2006, pp. 232-5.
Folsom AR, Hong CP. Magnesium intake and reduced risk of colon cancer in a prospective study of women. Am J Epidemiol. 2006;163(3):232-5.
Folsom, A. R., & Hong, C. P. (2006). Magnesium intake and reduced risk of colon cancer in a prospective study of women. American Journal of Epidemiology, 163(3), pp. 232-5.
Folsom AR, Hong CP. Magnesium Intake and Reduced Risk of Colon Cancer in a Prospective Study of Women. Am J Epidemiol. 2006 Feb 1;163(3):232-5. PubMed PMID: 16319289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium intake and reduced risk of colon cancer in a prospective study of women. AU - Folsom,Aaron R, AU - Hong,Ching-Ping, Y1 - 2005/11/30/ PY - 2005/12/2/pubmed PY - 2006/3/7/medline PY - 2005/12/2/entrez SP - 232 EP - 5 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 163 IS - 3 N2 - A recent prospective study among Swedish women suggested an inverse association of dietary magnesium intake with incidence of colorectal cancer. The authors assessed this association in a cohort of 35,196 Iowa women initially free of cancer and aged 55-69 years in 1986. Intakes of magnesium and other nutrients were assessed by food frequency questionnaire at baseline. Over 17 years of follow-up through 2002, 1,112 women developed colorectal cancer. After adjustment for age, energy, other nutrients, and risk factors for colorectal cancer, the hazard ratios of colorectal cancer across quintiles of magnesium intake were 1.00, 0.96, 0.83, 0.87, and 0.80 (95% confidence interval: 0.62, 1.03; p(trend) = 0.06). The association was largely absent for rectal cancer but, for colon cancer, the hazard ratios were 1.00, 1.00, 0.88, 0.85, and 0.77 (95% confidence interval: 0.58, 1.03; p(trend) = 0.04). These findings offer further evidence that a diet high in magnesium may reduce the occurrence of colon cancer among women. If replicated by other observational studies, a clinical trial would be needed to determine whether it is magnesium, specifically, and not other aspects of the contributing foods, that may offer benefit. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16319289/Magnesium_intake_and_reduced_risk_of_colon_cancer_in_a_prospective_study_of_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj037 DB - PRIME DP - Unbound Medicine ER -