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Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat.
Med Sci Monit 2005; 11(12):BR465-72MS

Abstract

BACKGROUND

High fruit intake is known to be associated with reduced risk of coronary heart disease. Our objective was to determine the effects of acute and chronic juice [grapefruit, orange, and pineapple] intake on plasma lipid profile and lipoprotein metabolism in normolipidemic rats.

MATERIAL/METHODS

The effects of acute juice intake were studied after three hours of a single juice-lipid load instilled intragastrically. In the chronic study, blood samples from fasted animals were subjected to analyses after six months of either water [control] or water-juice [1:1] intake.

RESULTS

In the acute study, pineapple and grapefruit significantly decreased plasma triacylglycerol [TAG], and chylomicron [CM] TAG and cholesterol concentrations concomitantly with delayed gastric emptying. Plasma cholesterol levels and very-low-density lipoprotein [VLDL] secretion and metabolism were not affected. In the chronic study, only grapefruit significantly decreased plasma and VLDL TAG concentrations and relative VLDL particle size with respect to other groups. All juices significantly increased VLDL apolipoprotein B [apoB] secretion, but plasma total apoB concentrations were highest in the grapefruit group and lowest in the orange and pineapple groups. No effect on blood cholesterol levels was observed.

CONCLUSIONS

The cardioprotective benefit of chronic juice intake in normolipidemic rat may be chiefly through mechanisms independent of a direct effect on blood lipid profile, although orange and pineapple, but not grapefruit, relatively improved the metabolism and clearance of blood lipoprotein particles. As a result of delayed gastric emptying, grapefruit and pineapple juices may moderate sharp increases in postprandial plasma TAG concentrations accompanying peak digestion and absorption.

Authors+Show Affiliations

Lebanese American University, Byblos, Lebanon. cdaher@lau.edu.lbNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16319784

Citation

Daher, Costantine F., et al. "Effect of Acute and Chronic Grapefruit, Orange, and Pineapple Juice Intake On Blood Lipid Profile in Normolipidemic Rat." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 11, no. 12, 2005, pp. BR465-72.
Daher CF, Abou-Khalil J, Baroody GM. Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. Med Sci Monit. 2005;11(12):BR465-72.
Daher, C. F., Abou-Khalil, J., & Baroody, G. M. (2005). Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 11(12), pp. BR465-72.
Daher CF, Abou-Khalil J, Baroody GM. Effect of Acute and Chronic Grapefruit, Orange, and Pineapple Juice Intake On Blood Lipid Profile in Normolipidemic Rat. Med Sci Monit. 2005;11(12):BR465-72. PubMed PMID: 16319784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. AU - Daher,Costantine F, AU - Abou-Khalil,Jamil, AU - Baroody,George M, Y1 - 2005/11/24/ PY - 2004/08/30/received PY - 2005/01/04/accepted PY - 2005/12/2/pubmed PY - 2006/3/8/medline PY - 2005/12/2/entrez SP - BR465 EP - 72 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 11 IS - 12 N2 - BACKGROUND: High fruit intake is known to be associated with reduced risk of coronary heart disease. Our objective was to determine the effects of acute and chronic juice [grapefruit, orange, and pineapple] intake on plasma lipid profile and lipoprotein metabolism in normolipidemic rats. MATERIAL/METHODS: The effects of acute juice intake were studied after three hours of a single juice-lipid load instilled intragastrically. In the chronic study, blood samples from fasted animals were subjected to analyses after six months of either water [control] or water-juice [1:1] intake. RESULTS: In the acute study, pineapple and grapefruit significantly decreased plasma triacylglycerol [TAG], and chylomicron [CM] TAG and cholesterol concentrations concomitantly with delayed gastric emptying. Plasma cholesterol levels and very-low-density lipoprotein [VLDL] secretion and metabolism were not affected. In the chronic study, only grapefruit significantly decreased plasma and VLDL TAG concentrations and relative VLDL particle size with respect to other groups. All juices significantly increased VLDL apolipoprotein B [apoB] secretion, but plasma total apoB concentrations were highest in the grapefruit group and lowest in the orange and pineapple groups. No effect on blood cholesterol levels was observed. CONCLUSIONS: The cardioprotective benefit of chronic juice intake in normolipidemic rat may be chiefly through mechanisms independent of a direct effect on blood lipid profile, although orange and pineapple, but not grapefruit, relatively improved the metabolism and clearance of blood lipoprotein particles. As a result of delayed gastric emptying, grapefruit and pineapple juices may moderate sharp increases in postprandial plasma TAG concentrations accompanying peak digestion and absorption. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/16319784/Effect_of_acute_and_chronic_grapefruit_orange_and_pineapple_juice_intake_on_blood_lipid_profile_in_normolipidemic_rat_ L2 - https://www.medscimonit.com/download/index/idArt/438850 DB - PRIME DP - Unbound Medicine ER -