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Bone mineral density in children with celiac disease. Effect of a Gluten-free diet.
Eur J Clin Nutr 2006; 60(3):358-63EJ

Abstract

OBJECTIVE

To assess the degree of osteopenia in children with celiac disease (CD) at the time of diagnosis and the effect of a gluten-free diet (GFD).

DESIGN

Longitudinal and prospective study.

SUBJECTS

In total, 24 children (18 girls, six boys) diagnosed with CD by means of an intestinal biopsy were included in the study. Mean+/-s.d. age was 4.9+/-4.3 years. In all, 16 patients were under (2.20+/-0.82 year) and eight were over the age of 4 years (10.30+/-2.90 year). The time between the first symptoms and diagnosis was 17.30+/-24.70 months (range: 2-109 months). Spine bone mineral content (BMC), area and bone mineral density (BMD) were measured by DXA at baseline and 1.17+/-0.93 years after GFD.

RESULTS

Before treatment, mean+/-s.d. BMD was 0.46+/-0.13 g/cm(2), the BMD Z-score was -1.36+/-1.20, and was below -1 s.d. in 14 patients (58%). BMC, area and BMD increased significantly on GFD. BMD increased from 0.46+/-0.13 to 0.55+/-0.13 g/cm(2) (P<0.001). BMD Z-score improved from -1.36+/-1.20 to -0.23+/-1.20 after GFD. However, BMD increased more than 1 s.d. in 15 of the 16 children under the age of 4 years, a similar increase was only observed in four of the eight children aged more than 4 years, some of whom did not follow GFD strictly. Height and weight increased significantly with GFD (P<0.001) and the increase correlated positively with the increase in BMD.

CONCLUSIONS

Axial BMD below -1 s.d. was found in 58% of children with celiac disease. Axial bone mass reverted to normal values in most children under the age of 4, who had low bone mass, all of whom followed GFD strictly.

Authors+Show Affiliations

Metabolismo Cálcico y Oseo, Endocrinología, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina. cristinatau@uol.com.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16319837

Citation

Tau, C, et al. "Bone Mineral Density in Children With Celiac Disease. Effect of a Gluten-free Diet." European Journal of Clinical Nutrition, vol. 60, no. 3, 2006, pp. 358-63.
Tau C, Mautalen C, De Rosa S, et al. Bone mineral density in children with celiac disease. Effect of a Gluten-free diet. Eur J Clin Nutr. 2006;60(3):358-63.
Tau, C., Mautalen, C., De Rosa, S., Roca, A., & Valenzuela, X. (2006). Bone mineral density in children with celiac disease. Effect of a Gluten-free diet. European Journal of Clinical Nutrition, 60(3), pp. 358-63.
Tau C, et al. Bone Mineral Density in Children With Celiac Disease. Effect of a Gluten-free Diet. Eur J Clin Nutr. 2006;60(3):358-63. PubMed PMID: 16319837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density in children with celiac disease. Effect of a Gluten-free diet. AU - Tau,C, AU - Mautalen,C, AU - De Rosa,S, AU - Roca,A, AU - Valenzuela,X, PY - 2005/12/2/pubmed PY - 2006/7/25/medline PY - 2005/12/2/entrez SP - 358 EP - 63 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 3 N2 - OBJECTIVE: To assess the degree of osteopenia in children with celiac disease (CD) at the time of diagnosis and the effect of a gluten-free diet (GFD). DESIGN: Longitudinal and prospective study. SUBJECTS: In total, 24 children (18 girls, six boys) diagnosed with CD by means of an intestinal biopsy were included in the study. Mean+/-s.d. age was 4.9+/-4.3 years. In all, 16 patients were under (2.20+/-0.82 year) and eight were over the age of 4 years (10.30+/-2.90 year). The time between the first symptoms and diagnosis was 17.30+/-24.70 months (range: 2-109 months). Spine bone mineral content (BMC), area and bone mineral density (BMD) were measured by DXA at baseline and 1.17+/-0.93 years after GFD. RESULTS: Before treatment, mean+/-s.d. BMD was 0.46+/-0.13 g/cm(2), the BMD Z-score was -1.36+/-1.20, and was below -1 s.d. in 14 patients (58%). BMC, area and BMD increased significantly on GFD. BMD increased from 0.46+/-0.13 to 0.55+/-0.13 g/cm(2) (P<0.001). BMD Z-score improved from -1.36+/-1.20 to -0.23+/-1.20 after GFD. However, BMD increased more than 1 s.d. in 15 of the 16 children under the age of 4 years, a similar increase was only observed in four of the eight children aged more than 4 years, some of whom did not follow GFD strictly. Height and weight increased significantly with GFD (P<0.001) and the increase correlated positively with the increase in BMD. CONCLUSIONS: Axial BMD below -1 s.d. was found in 58% of children with celiac disease. Axial bone mass reverted to normal values in most children under the age of 4, who had low bone mass, all of whom followed GFD strictly. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16319837/Bone_mineral_density_in_children_with_celiac_disease__Effect_of_a_Gluten_free_diet_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602323 DB - PRIME DP - Unbound Medicine ER -