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[Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina].
Ter Arkh. 2005; 77(10):71-5.TA

Abstract

AIM

Assessment of efficacy of treatment of coronary heart disease (CHD) patients suffering from stable effort angina of functional class II-III with the drug isosorbide-5-mononitrate Mono Mac 50 depo (MM 50 D).

MATERIAL AND METHODS

Clinical indices, exercise tolerance, endothelial function (the study of brachial artery in reactive hyperemia and sublingual intake of nitroglycerin) were studied in 30 patients with stable angina FC II-III before the treatment, 1 and 3 months after the treatment.

RESULTS

MM 50D significantly widens diameter of the brachial artery (by 11.6%), lowers nitroglycerin-dependent vasodilation (from 16% to 10.4% in a month and to 10.2% in 3 months) and blood flow speed in reactive hyperemia. An absolute increment of the brachial artery diameter in reactive hyperemia test remained unchanged. The ratio flow-dependent vasodilation/nitroglycerin-dependent vasodilation increased in the course of therapy from 0.67 to 0.91. The drug produced clinical improvement (anginal attacks rate diminished by 70 and 85%, respectively) and increased exercise tolerance (the threshold performance rose by 28%, total load time--by 30%).

CONCLUSION

It is important to use complex assessment of hemodynamic component of endothelial function in the treatment with nitrates.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

rus

PubMed ID

16320691

Citation

Kazachkina, S S., et al. "[Effects of Isosorbide-5-mononitrate On Clinical Condition, Bicycle Ergometry Results, Endothelium-dependent Vasodilation in Patients With Ischemic Heart Disease With Stable Effort Angina]." Terapevticheskii Arkhiv, vol. 77, no. 10, 2005, pp. 71-5.
Kazachkina SS, Balakhonova TV, Lupanov VP, et al. [Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina]. Ter Arkh. 2005;77(10):71-5.
Kazachkina, S. S., Balakhonova, T. V., Lupanov, V. P., Pogorelova, O. A., Rogoza, A. N., & Naumov, V. G. (2005). [Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina]. Terapevticheskii Arkhiv, 77(10), 71-5.
Kazachkina SS, et al. [Effects of Isosorbide-5-mononitrate On Clinical Condition, Bicycle Ergometry Results, Endothelium-dependent Vasodilation in Patients With Ischemic Heart Disease With Stable Effort Angina]. Ter Arkh. 2005;77(10):71-5. PubMed PMID: 16320691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina]. AU - Kazachkina,S S, AU - Balakhonova,T V, AU - Lupanov,V P, AU - Pogorelova,O A, AU - Rogoza,A N, AU - Naumov,V G, PY - 2005/12/3/pubmed PY - 2006/2/7/medline PY - 2005/12/3/entrez SP - 71 EP - 5 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 77 IS - 10 N2 - AIM: Assessment of efficacy of treatment of coronary heart disease (CHD) patients suffering from stable effort angina of functional class II-III with the drug isosorbide-5-mononitrate Mono Mac 50 depo (MM 50 D). MATERIAL AND METHODS: Clinical indices, exercise tolerance, endothelial function (the study of brachial artery in reactive hyperemia and sublingual intake of nitroglycerin) were studied in 30 patients with stable angina FC II-III before the treatment, 1 and 3 months after the treatment. RESULTS: MM 50D significantly widens diameter of the brachial artery (by 11.6%), lowers nitroglycerin-dependent vasodilation (from 16% to 10.4% in a month and to 10.2% in 3 months) and blood flow speed in reactive hyperemia. An absolute increment of the brachial artery diameter in reactive hyperemia test remained unchanged. The ratio flow-dependent vasodilation/nitroglycerin-dependent vasodilation increased in the course of therapy from 0.67 to 0.91. The drug produced clinical improvement (anginal attacks rate diminished by 70 and 85%, respectively) and increased exercise tolerance (the threshold performance rose by 28%, total load time--by 30%). CONCLUSION: It is important to use complex assessment of hemodynamic component of endothelial function in the treatment with nitrates. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/16320691/[Effects_of_isosorbide_5_mononitrate_on_clinical_condition_bicycle_ergometry_results_endothelium_dependent_vasodilation_in_patients_with_ischemic_heart_disease_with_stable_effort_angina]_ L2 - https://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -