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[Study on differentially expressed genes of ulcerative colitis in the rat treated by herbs-partitioned moxibustion].
Zhongguo Zhen Jiu. 2005 May; 25(5):359-65.ZZ

Abstract

OBJECTIVE

To probe the mechanism of herbs-partitioned moxibustion for treatment of ulcerative colitis.

METHODS

The rats with ulcerative colitis were randomly divided into 3 groups, normal control group, model group, and herbs-partitioned moxibustion group. The rats in the herbs-partitioned moxibustion group were treated by herbs-partitioned moxibustion at bilateral Tianshu (ST 25). BiostarR-40s gene chip was applied to detect the differentially expressed gene of their colonic tissues and fluorescence quantitative polymerase chain reaction was employed to confirm the results of the microarray analysis with interleukin-1 beta messenger RNA (IL-1beta mRNA) expression.

RESULTS

Of 174 differential expression genes identified, 28 genes (including 7 known genes) elevated in rats of ulcerative colitis were down-regulated and 146 genes (including 42 known genes) reduced in the rat of ulcerative colitis were up-regulated after herbs-partitioned moxibustion treatment.

CONCLUSION

Many abnormally expressed genes are involved in occurrence of ulcerative colitis and herbs-partitioned moxibustion can regulate expression of IL-1beta and other genes to exert therapeutic effect.

Authors+Show Affiliations

Shanghai Research Institute of Acupuncture and Meridians, Shanghai 200030, China. wuhuangan@citiz.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

16320758

Citation

Wu, Huan-Gan, et al. "[Study On Differentially Expressed Genes of Ulcerative Colitis in the Rat Treated By Herbs-partitioned Moxibustion]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 25, no. 5, 2005, pp. 359-65.
Wu HG, Liu HR, Zhao C, et al. [Study on differentially expressed genes of ulcerative colitis in the rat treated by herbs-partitioned moxibustion]. Zhongguo Zhen Jiu. 2005;25(5):359-65.
Wu, H. G., Liu, H. R., Zhao, C., Zhang, W., Wu, X. F., Zhou, S., Shi, Y., & Liu, M. (2005). [Study on differentially expressed genes of ulcerative colitis in the rat treated by herbs-partitioned moxibustion]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 25(5), 359-65.
Wu HG, et al. [Study On Differentially Expressed Genes of Ulcerative Colitis in the Rat Treated By Herbs-partitioned Moxibustion]. Zhongguo Zhen Jiu. 2005;25(5):359-65. PubMed PMID: 16320758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on differentially expressed genes of ulcerative colitis in the rat treated by herbs-partitioned moxibustion]. AU - Wu,Huan-Gan, AU - Liu,Hui-Rong, AU - Zhao,Chen, AU - Zhang,Wei, AU - Wu,Xue-Fei, AU - Zhou,Shuang, AU - Shi,Yin, AU - Liu,Min, PY - 2005/12/3/pubmed PY - 2016/4/24/medline PY - 2005/12/3/entrez SP - 359 EP - 65 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 25 IS - 5 N2 - OBJECTIVE: To probe the mechanism of herbs-partitioned moxibustion for treatment of ulcerative colitis. METHODS: The rats with ulcerative colitis were randomly divided into 3 groups, normal control group, model group, and herbs-partitioned moxibustion group. The rats in the herbs-partitioned moxibustion group were treated by herbs-partitioned moxibustion at bilateral Tianshu (ST 25). BiostarR-40s gene chip was applied to detect the differentially expressed gene of their colonic tissues and fluorescence quantitative polymerase chain reaction was employed to confirm the results of the microarray analysis with interleukin-1 beta messenger RNA (IL-1beta mRNA) expression. RESULTS: Of 174 differential expression genes identified, 28 genes (including 7 known genes) elevated in rats of ulcerative colitis were down-regulated and 146 genes (including 42 known genes) reduced in the rat of ulcerative colitis were up-regulated after herbs-partitioned moxibustion treatment. CONCLUSION: Many abnormally expressed genes are involved in occurrence of ulcerative colitis and herbs-partitioned moxibustion can regulate expression of IL-1beta and other genes to exert therapeutic effect. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/16320758/[Study_on_differentially_expressed_genes_of_ulcerative_colitis_in_the_rat_treated_by_herbs_partitioned_moxibustion]_ L2 - https://medlineplus.gov/ulcerativecolitis.html DB - PRIME DP - Unbound Medicine ER -