Hydrogen bond catalyzed enantioselective vinylogous Mukaiyama aldol reaction.Org Lett. 2005 Dec 08; 7(25):5657-60.OL
[chemical reaction: see text]. The concept of hydrogen bonding catalysis was extended to the vinylogous Mukaiyama aldol reaction, which gives rapid access to polyketide derivatives. The reaction of the silyldienol ether shown and a range of aldehydes catalyzed by TADDOL proceeds regiospecifically to produce the addition products in good yields and enantiomeric excesses.