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Prediction of Alzheimer's disease in mild cognitive impairment: a prospective study in Taiwan.
Neurobiol Aging. 2006 Dec; 27(12):1797-806.NA

Abstract

The relationship between apolipoprotein E (ApoE) and clinical manifestations of mild cognitive impairment (MCI) has not been investigated in non-Caucasian populations. This prospective study was conducted in an ethnic Chinese population to evaluate the correlations of ApoE genotype, cognitive performance, medial temporal structure volumes, and clinical outcome in amnestic MCI. Twenty normal elders, 58 MCI, and 20 mild Alzheimer's disease (AD) patients received neuropsychological, MRI, and ApoE genotype assessments at baseline. Patients with MCI had intermediate cognitive performance and hippocampal volumes between those in normal and AD groups. In each diagnostic group, epsilon4 carriers (E4+) consistently had smaller hippocampal volume than non-carriers (E4-) did. Nineteen MCI subjects (32.7%) converted to AD during the 3-year study period. Compared with MCI non-converters and E4- MCI converters, E4+ MCI converters had the smallest hippocampal volume. However, epsilon4 was not a predictor for AD. Both cognitive performance and hippocampal volume were predictive for progression to AD. However, stepwise Cox regression model integrating both neuropsychological and radiological variables showed that global cognitive performance was the only significant predictor for AD. A poor global cognitive score may be more crucial than a small hippocampal volume in the prediction of AD.

Authors+Show Affiliations

Department of Neurology, National Yang-Ming University School of Medicine, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16321457

Citation

Wang, P N., et al. "Prediction of Alzheimer's Disease in Mild Cognitive Impairment: a Prospective Study in Taiwan." Neurobiology of Aging, vol. 27, no. 12, 2006, pp. 1797-806.
Wang PN, Lirng JF, Lin KN, et al. Prediction of Alzheimer's disease in mild cognitive impairment: a prospective study in Taiwan. Neurobiol Aging. 2006;27(12):1797-806.
Wang, P. N., Lirng, J. F., Lin, K. N., Chang, F. C., & Liu, H. C. (2006). Prediction of Alzheimer's disease in mild cognitive impairment: a prospective study in Taiwan. Neurobiology of Aging, 27(12), 1797-806.
Wang PN, et al. Prediction of Alzheimer's Disease in Mild Cognitive Impairment: a Prospective Study in Taiwan. Neurobiol Aging. 2006;27(12):1797-806. PubMed PMID: 16321457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediction of Alzheimer's disease in mild cognitive impairment: a prospective study in Taiwan. AU - Wang,P N, AU - Lirng,J F, AU - Lin,K N, AU - Chang,F C, AU - Liu,H C, PY - 2005/03/20/received PY - 2005/10/02/revised PY - 2005/10/05/accepted PY - 2005/12/3/pubmed PY - 2007/1/4/medline PY - 2005/12/3/entrez SP - 1797 EP - 806 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 27 IS - 12 N2 - The relationship between apolipoprotein E (ApoE) and clinical manifestations of mild cognitive impairment (MCI) has not been investigated in non-Caucasian populations. This prospective study was conducted in an ethnic Chinese population to evaluate the correlations of ApoE genotype, cognitive performance, medial temporal structure volumes, and clinical outcome in amnestic MCI. Twenty normal elders, 58 MCI, and 20 mild Alzheimer's disease (AD) patients received neuropsychological, MRI, and ApoE genotype assessments at baseline. Patients with MCI had intermediate cognitive performance and hippocampal volumes between those in normal and AD groups. In each diagnostic group, epsilon4 carriers (E4+) consistently had smaller hippocampal volume than non-carriers (E4-) did. Nineteen MCI subjects (32.7%) converted to AD during the 3-year study period. Compared with MCI non-converters and E4- MCI converters, E4+ MCI converters had the smallest hippocampal volume. However, epsilon4 was not a predictor for AD. Both cognitive performance and hippocampal volume were predictive for progression to AD. However, stepwise Cox regression model integrating both neuropsychological and radiological variables showed that global cognitive performance was the only significant predictor for AD. A poor global cognitive score may be more crucial than a small hippocampal volume in the prediction of AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/16321457/Prediction_of_Alzheimer's_disease_in_mild_cognitive_impairment:_a_prospective_study_in_Taiwan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(05)00316-7 DB - PRIME DP - Unbound Medicine ER -