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pH-responsive amphiphilic hydrogel networks with IPN structure: a strategy for controlled drug release.

Abstract

A pH-responsive amphiphilic hydrogel with interpenetrating polymer networks (IPN) structure for controlled drug release was proposed. The IPN was constructed with hydrophilic poly(acrylic acid) (PAA) and hydrophobic poly(butyl acrylate) (PBA). Using drug N-acetyl-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of the IPN were investigated. It is found that not only the release of MEL from the IPN can respond to change in pH, but also the presence of hydrophobic network can overcome disadvantageous burst effect of hydrophilic network. This may be a result of hydrophobic aggregation encapsulating MEL molecules.

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  • Authors+Show Affiliations

    ,

    Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an 710072, PR China. yyliu666@yahoo.com.cn

    , , , ,

    Source

    International journal of pharmaceutics 308:1-2 2006 Feb 3 pg 205-9

    MeSH

    Acrylates
    Acrylic Resins
    Delayed-Action Preparations
    Hydrogels
    Hydrogen-Ion Concentration
    Melatonin
    Molecular Conformation
    Polymers
    Solubility
    Surface Properties
    Time Factors
    Transition Temperature
    Ultraviolet Rays
    Water

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16321489

    Citation

    TY - JOUR T1 - pH-responsive amphiphilic hydrogel networks with IPN structure: a strategy for controlled drug release. AU - Liu,Yu-Yang, AU - Fan,Xiao-Dong, AU - Wei,Bo-Rong, AU - Si,Qing-Fa, AU - Chen,Wei-Xing, AU - Sun,Le, PY - 2005/6/14/received PY - 2005/9/27/revised PY - 2005/10/15/accepted PY - 2005/12/3/pubmed PY - 2006/4/21/medline PY - 2005/12/3/entrez SP - 205 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 308 IS - 1-2 N2 - A pH-responsive amphiphilic hydrogel with interpenetrating polymer networks (IPN) structure for controlled drug release was proposed. The IPN was constructed with hydrophilic poly(acrylic acid) (PAA) and hydrophobic poly(butyl acrylate) (PBA). Using drug N-acetyl-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of the IPN were investigated. It is found that not only the release of MEL from the IPN can respond to change in pH, but also the presence of hydrophobic network can overcome disadvantageous burst effect of hydrophilic network. This may be a result of hydrophobic aggregation encapsulating MEL molecules. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/16321489/pH_responsive_amphiphilic_hydrogel_networks_with_IPN_structure:_a_strategy_for_controlled_drug_release_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0378-5173(05)00670-8 ER -