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The relationship of age, blood pressure, serum cholesterol and smoking habits with the risk of typical and atypical coronary heart disease death in the European cohorts of the Seven Countries Study.
Int J Cardiol 2006; 106(2):157-63IJ

Abstract

OBJECTIVE

To explore whether "typical" coronary heart disease (CHD) such as fatal myocardial infarction and sudden death relate to major cardiovascular risk factors in the same way as the "atypical" CHD, such as fatal heart failure and chronic arrhythmias.

DESIGN AND SETTING

Ten cohorts (6633 cardiovascular disease-free men, aged 40-59) in five European countries were examined, age and three major risk factors were measured (systolic blood pressure, serum cholesterol, and smoking habits) and 35-year mortality data were collected. Proportional hazard models were solved with typical and atypical CHD deaths treated separately.

RESULTS

Death rates from typical and atypical CHD were inversely related among the five countries. Mean age at death was significantly higher for atypical than typical (75.8 versus 71.6 years; p < 0.001). In the multivariate analysis conducted on pools of 5 countries (adjusted for countries), the relationship of risk factors with typical CHD was direct and significant for age (hazard ratio-HR-for 5 years of age 1.44 (95% CI 1.36-1.52)), systolic blood pressure (HR for 20 mm Hg, 1.39 (95% CI 1.32-1.47)), serum cholesterol (HR for 1 mmol/l of 1.22 (95% CI 1.16-1.27)) and smoking habits (HR smokers versus non-smokers of 1.39 (95% CI 1.24-1.57)). For atypical CHD, age had a larger HR of 2.27 (95% CI 2.05-2.52), systolic blood pressure had a smaller HR of 1.28 (95% CI 1.16-1.41), serum cholesterol had an inverse non-significant HR of 0.90 (0.58-1.58) and smoking habits had a larger HR of 1.54 (95% CI 1.26-1.89).

CONCLUSIONS

Age and serum cholesterol were differently related with typical and atypical CHD deaths, suggesting different etiologies for these coronary diseases.

Authors+Show Affiliations

Association for Cardiac Research, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16321686

Citation

Menotti, Alessandro, et al. "The Relationship of Age, Blood Pressure, Serum Cholesterol and Smoking Habits With the Risk of Typical and Atypical Coronary Heart Disease Death in the European Cohorts of the Seven Countries Study." International Journal of Cardiology, vol. 106, no. 2, 2006, pp. 157-63.
Menotti A, Lanti M, Nedeljkovic S, et al. The relationship of age, blood pressure, serum cholesterol and smoking habits with the risk of typical and atypical coronary heart disease death in the European cohorts of the Seven Countries Study. Int J Cardiol. 2006;106(2):157-63.
Menotti, A., Lanti, M., Nedeljkovic, S., Nissinen, A., Kafatos, A., & Kromhout, D. (2006). The relationship of age, blood pressure, serum cholesterol and smoking habits with the risk of typical and atypical coronary heart disease death in the European cohorts of the Seven Countries Study. International Journal of Cardiology, 106(2), pp. 157-63.
Menotti A, et al. The Relationship of Age, Blood Pressure, Serum Cholesterol and Smoking Habits With the Risk of Typical and Atypical Coronary Heart Disease Death in the European Cohorts of the Seven Countries Study. Int J Cardiol. 2006 Jan 13;106(2):157-63. PubMed PMID: 16321686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of age, blood pressure, serum cholesterol and smoking habits with the risk of typical and atypical coronary heart disease death in the European cohorts of the Seven Countries Study. AU - Menotti,Alessandro, AU - Lanti,Mariapaola, AU - Nedeljkovic,Srecko, AU - Nissinen,Aulikki, AU - Kafatos,Anthony, AU - Kromhout,Daan, PY - 2004/07/19/received PY - 2004/10/26/revised PY - 2004/12/24/accepted PY - 2005/12/3/pubmed PY - 2006/3/17/medline PY - 2005/12/3/entrez SP - 157 EP - 63 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 106 IS - 2 N2 - OBJECTIVE: To explore whether "typical" coronary heart disease (CHD) such as fatal myocardial infarction and sudden death relate to major cardiovascular risk factors in the same way as the "atypical" CHD, such as fatal heart failure and chronic arrhythmias. DESIGN AND SETTING: Ten cohorts (6633 cardiovascular disease-free men, aged 40-59) in five European countries were examined, age and three major risk factors were measured (systolic blood pressure, serum cholesterol, and smoking habits) and 35-year mortality data were collected. Proportional hazard models were solved with typical and atypical CHD deaths treated separately. RESULTS: Death rates from typical and atypical CHD were inversely related among the five countries. Mean age at death was significantly higher for atypical than typical (75.8 versus 71.6 years; p < 0.001). In the multivariate analysis conducted on pools of 5 countries (adjusted for countries), the relationship of risk factors with typical CHD was direct and significant for age (hazard ratio-HR-for 5 years of age 1.44 (95% CI 1.36-1.52)), systolic blood pressure (HR for 20 mm Hg, 1.39 (95% CI 1.32-1.47)), serum cholesterol (HR for 1 mmol/l of 1.22 (95% CI 1.16-1.27)) and smoking habits (HR smokers versus non-smokers of 1.39 (95% CI 1.24-1.57)). For atypical CHD, age had a larger HR of 2.27 (95% CI 2.05-2.52), systolic blood pressure had a smaller HR of 1.28 (95% CI 1.16-1.41), serum cholesterol had an inverse non-significant HR of 0.90 (0.58-1.58) and smoking habits had a larger HR of 1.54 (95% CI 1.26-1.89). CONCLUSIONS: Age and serum cholesterol were differently related with typical and atypical CHD deaths, suggesting different etiologies for these coronary diseases. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16321686/The_relationship_of_age_blood_pressure_serum_cholesterol_and_smoking_habits_with_the_risk_of_typical_and_atypical_coronary_heart_disease_death_in_the_European_cohorts_of_the_Seven_Countries_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00390-6 DB - PRIME DP - Unbound Medicine ER -