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Chronic idiopathic myelofibrosis terminating in extramedullary anaplastic plasmacytoma.
Leuk Lymphoma. 2006 Feb; 47(2):315-22.LL

Abstract

Chronic idiopathic myelofibrosis (CIMF) is a chronic myeloproliferative disorder (CMPD) with progressive fibrosis and extramedullary hematopoiesis. Similar to other CMPDs, the stem cell in CIMF has the potential to differentiate into myeloid or lymphoid lineages, and thus CIMF can culminate in acute leukemia of myeloid or, rarely, lymphoid lineage. We describe an unusual case of CIMF terminating in extramedullary anaplastic plasmacytoma. The patient was a 61-year-old male with an 11-year history of CIMF. His course was complicated by rapidly growing abdominal and inguinal lymphadenopathy. Lymph node biopsy revealed a diffuse undifferentiated infiltrate in the background of extramedullary hematopoiesis. Flow cytometric and immunohistochemical analysis demonstrated plasma cell-related antigens (CD138, CD38, cytoplasmic kappa light chain), epithelial membrane antigen and CD43 in the tumor cells. The myeloid, B-cell or T-cell markers were negative. A clonal immunoglobulin heavy chain gene rearrangement was identified by polymerase chain reaction. The plasma cell origin was further confirmed by electron microscopic examination, which revealed stacks of rough endoplasmic reticulum. Monoclonal gammopathy may occur in CIMF, and rare cases of simultaneous plasma cell myeloma and CIMF have been reported in the literature. However, to the best of our knowledge, this is the first report of CIMF terminating in extramedullary anaplastic plasmacytoma.

Authors+Show Affiliations

Department of Pathology, Georgetown University Hospital, 3900 Reservoir Road, NW, Washington, DC 20007, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16321864

Citation

Liu, Min-Ling, et al. "Chronic Idiopathic Myelofibrosis Terminating in Extramedullary Anaplastic Plasmacytoma." Leukemia & Lymphoma, vol. 47, no. 2, 2006, pp. 315-22.
Liu ML, Kallakury B, Kessler C, et al. Chronic idiopathic myelofibrosis terminating in extramedullary anaplastic plasmacytoma. Leuk Lymphoma. 2006;47(2):315-22.
Liu, M. L., Kallakury, B., Kessler, C., Hartmann, D. P., Azumi, N., & Ozdemirli, M. (2006). Chronic idiopathic myelofibrosis terminating in extramedullary anaplastic plasmacytoma. Leukemia & Lymphoma, 47(2), 315-22.
Liu ML, et al. Chronic Idiopathic Myelofibrosis Terminating in Extramedullary Anaplastic Plasmacytoma. Leuk Lymphoma. 2006;47(2):315-22. PubMed PMID: 16321864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic idiopathic myelofibrosis terminating in extramedullary anaplastic plasmacytoma. AU - Liu,Min-Ling, AU - Kallakury,Bhaskar, AU - Kessler,Craig, AU - Hartmann,Dan-Paul, AU - Azumi,Norio, AU - Ozdemirli,Metin, PY - 2005/12/3/pubmed PY - 2006/6/21/medline PY - 2005/12/3/entrez SP - 315 EP - 22 JF - Leukemia & lymphoma JO - Leuk Lymphoma VL - 47 IS - 2 N2 - Chronic idiopathic myelofibrosis (CIMF) is a chronic myeloproliferative disorder (CMPD) with progressive fibrosis and extramedullary hematopoiesis. Similar to other CMPDs, the stem cell in CIMF has the potential to differentiate into myeloid or lymphoid lineages, and thus CIMF can culminate in acute leukemia of myeloid or, rarely, lymphoid lineage. We describe an unusual case of CIMF terminating in extramedullary anaplastic plasmacytoma. The patient was a 61-year-old male with an 11-year history of CIMF. His course was complicated by rapidly growing abdominal and inguinal lymphadenopathy. Lymph node biopsy revealed a diffuse undifferentiated infiltrate in the background of extramedullary hematopoiesis. Flow cytometric and immunohistochemical analysis demonstrated plasma cell-related antigens (CD138, CD38, cytoplasmic kappa light chain), epithelial membrane antigen and CD43 in the tumor cells. The myeloid, B-cell or T-cell markers were negative. A clonal immunoglobulin heavy chain gene rearrangement was identified by polymerase chain reaction. The plasma cell origin was further confirmed by electron microscopic examination, which revealed stacks of rough endoplasmic reticulum. Monoclonal gammopathy may occur in CIMF, and rare cases of simultaneous plasma cell myeloma and CIMF have been reported in the literature. However, to the best of our knowledge, this is the first report of CIMF terminating in extramedullary anaplastic plasmacytoma. SN - 1042-8194 UR - https://www.unboundmedicine.com/medline/citation/16321864/Chronic_idiopathic_myelofibrosis_terminating_in_extramedullary_anaplastic_plasmacytoma_ L2 - https://www.tandfonline.com/doi/full/10.1080/10428190500286358 DB - PRIME DP - Unbound Medicine ER -