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3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.
Biol Psychiatry. 2006 Jun 15; 59(12):1219-26.BP

Abstract

BACKGROUND

+/-3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug that causes cognitive deficits in humans. A rat model for learning and memory deficits has not been established, although some cognitive deficits have been reported.

METHODS

Male Sprague-Dawley rats were treated with MDMA (15 mg/kg x 4 doses) or saline (SAL) (n = 20/treatment group) and tested in different learning paradigms: 1) path integration in the Cincinnati water maze (CWM), 2) spatial learning in the Morris water maze (MWM), and 3) novel object recognition (NOR). One week after drug administration, testing began in the CWM, then four phases of MWM, and finally NOR. Following behavioral testing, monoamine levels were assessed.

RESULTS

+/-3,4-Methylenedioxymethamphetamine-treated rats committed more CWM errors than did SAL-treated rats. +/-3,4-Methylenedioxymethamphetamine-treated animals were further from the former platform position during each 30-second MWM probe trial but showed no differences during learning trials with the platform present. There were no group differences in NOR. +/-3,4-Methylenedioxymethamphetamine depleted serotonin in all brain regions and dopamine in the striatum.

CONCLUSIONS

+/-3,4-Methylenedioxymethamphetamine produced MWM reference memory deficits even after complex learning in the CWM, where deficits in path integration learning occurred. Assessment of path integration may provide a sensitive index of MDMA-induced learning deficits.

Authors+Show Affiliations

Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16324685

Citation

Able, Jessica A., et al. "3,4-Methylenedioxymethamphetamine in Adult Rats Produces Deficits in Path Integration and Spatial Reference Memory." Biological Psychiatry, vol. 59, no. 12, 2006, pp. 1219-26.
Able JA, Gudelsky GA, Vorhees CV, et al. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biol Psychiatry. 2006;59(12):1219-26.
Able, J. A., Gudelsky, G. A., Vorhees, C. V., & Williams, M. T. (2006). 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological Psychiatry, 59(12), 1219-26.
Able JA, et al. 3,4-Methylenedioxymethamphetamine in Adult Rats Produces Deficits in Path Integration and Spatial Reference Memory. Biol Psychiatry. 2006 Jun 15;59(12):1219-26. PubMed PMID: 16324685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. AU - Able,Jessica A, AU - Gudelsky,Gary A, AU - Vorhees,Charles V, AU - Williams,Michael T, Y1 - 2005/12/01/ PY - 2005/05/13/received PY - 2005/08/26/revised PY - 2005/09/12/accepted PY - 2005/12/6/pubmed PY - 2006/9/8/medline PY - 2005/12/6/entrez SP - 1219 EP - 26 JF - Biological psychiatry JO - Biol Psychiatry VL - 59 IS - 12 N2 - BACKGROUND: +/-3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug that causes cognitive deficits in humans. A rat model for learning and memory deficits has not been established, although some cognitive deficits have been reported. METHODS: Male Sprague-Dawley rats were treated with MDMA (15 mg/kg x 4 doses) or saline (SAL) (n = 20/treatment group) and tested in different learning paradigms: 1) path integration in the Cincinnati water maze (CWM), 2) spatial learning in the Morris water maze (MWM), and 3) novel object recognition (NOR). One week after drug administration, testing began in the CWM, then four phases of MWM, and finally NOR. Following behavioral testing, monoamine levels were assessed. RESULTS: +/-3,4-Methylenedioxymethamphetamine-treated rats committed more CWM errors than did SAL-treated rats. +/-3,4-Methylenedioxymethamphetamine-treated animals were further from the former platform position during each 30-second MWM probe trial but showed no differences during learning trials with the platform present. There were no group differences in NOR. +/-3,4-Methylenedioxymethamphetamine depleted serotonin in all brain regions and dopamine in the striatum. CONCLUSIONS: +/-3,4-Methylenedioxymethamphetamine produced MWM reference memory deficits even after complex learning in the CWM, where deficits in path integration learning occurred. Assessment of path integration may provide a sensitive index of MDMA-induced learning deficits. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16324685/34_Methylenedioxymethamphetamine_in_adult_rats_produces_deficits_in_path_integration_and_spatial_reference_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)01105-4 DB - PRIME DP - Unbound Medicine ER -