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Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors.
Oral Oncol. 2006 Mar; 42(3):288-96.OO

Abstract

We investigated whether herpes simplex viruses, HSV-1 and HSV-2, are cofactors of head and neck cancer (HNC) in association with tobacco, alcohol, or HPV-16 infection. The study included 164 HNC cases and 295 controls. Serologic tests were used to distinguish HSV-1 and HSV-2. Antibodies to anti-VLP HPV-16 and HPV-16 E6 and E7 were evaluated by ELISA. After adjusting for age, tobacco, alcohol use, and number of sexual partners, risk of cancer was not significantly increased in those with HSV-1 [adjusted odds ratio (OR)=0.7] or HSV-2 (OR=0.8) compared to HSV-negative patients. Although heavy use of tobacco, alcohol and HPV-16 infection was associated with an increased risk of HNC, the adjusted risk among those infected with HSV-1 or HSV-2 lowered the odds compared to those who were not infected. Heavy smokers (OR=1.7) and heavy drinkers infected with HSV-1 (OR=4.2) or HSV-2 (smokers: OR=1.6; drinkers: OR=3.2) had lower odds compared to seronegative HSV-1 heavy users (smokers: OR=2.5; drinkers: OR=5.5) or HSV-2 (smokers: OR=1.9; drinkers: OR=6.2). Those seropositive to HPV-16 E6 and/or E7 but not HSV-1 (OR=27.4) or HSV-2 (OR=18.0) had higher risk of HNC compared to those infected with HSV-1 (OR=16.7) or HSV-2 (not estimable). These findings suggest that seropositivity to HSV-1 and HSV-2, although not independent risk factors for HNC, may modify the risk of HNC associated with exposure to tobacco, alcohol, or HPV-HR.

Authors+Show Affiliations

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16324878

Citation

Parker, Tina M., et al. "Head and Neck Cancer Associated With Herpes Simplex Virus 1 and 2 and Other Risk Factors." Oral Oncology, vol. 42, no. 3, 2006, pp. 288-96.
Parker TM, Smith EM, Ritchie JM, et al. Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. Oral Oncol. 2006;42(3):288-96.
Parker, T. M., Smith, E. M., Ritchie, J. M., Haugen, T. H., Vonka, V., Turek, L. P., & Hamsikova, E. (2006). Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. Oral Oncology, 42(3), 288-96.
Parker TM, et al. Head and Neck Cancer Associated With Herpes Simplex Virus 1 and 2 and Other Risk Factors. Oral Oncol. 2006;42(3):288-96. PubMed PMID: 16324878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. AU - Parker,Tina M, AU - Smith,Elaine M, AU - Ritchie,Justine M, AU - Haugen,Thomas H, AU - Vonka,Vladimir, AU - Turek,Lubomir P, AU - Hamsikova,Eva, PY - 2005/08/03/received PY - 2005/08/05/accepted PY - 2005/12/6/pubmed PY - 2006/11/14/medline PY - 2005/12/6/entrez SP - 288 EP - 96 JF - Oral oncology JO - Oral Oncol. VL - 42 IS - 3 N2 - We investigated whether herpes simplex viruses, HSV-1 and HSV-2, are cofactors of head and neck cancer (HNC) in association with tobacco, alcohol, or HPV-16 infection. The study included 164 HNC cases and 295 controls. Serologic tests were used to distinguish HSV-1 and HSV-2. Antibodies to anti-VLP HPV-16 and HPV-16 E6 and E7 were evaluated by ELISA. After adjusting for age, tobacco, alcohol use, and number of sexual partners, risk of cancer was not significantly increased in those with HSV-1 [adjusted odds ratio (OR)=0.7] or HSV-2 (OR=0.8) compared to HSV-negative patients. Although heavy use of tobacco, alcohol and HPV-16 infection was associated with an increased risk of HNC, the adjusted risk among those infected with HSV-1 or HSV-2 lowered the odds compared to those who were not infected. Heavy smokers (OR=1.7) and heavy drinkers infected with HSV-1 (OR=4.2) or HSV-2 (smokers: OR=1.6; drinkers: OR=3.2) had lower odds compared to seronegative HSV-1 heavy users (smokers: OR=2.5; drinkers: OR=5.5) or HSV-2 (smokers: OR=1.9; drinkers: OR=6.2). Those seropositive to HPV-16 E6 and/or E7 but not HSV-1 (OR=27.4) or HSV-2 (OR=18.0) had higher risk of HNC compared to those infected with HSV-1 (OR=16.7) or HSV-2 (not estimable). These findings suggest that seropositivity to HSV-1 and HSV-2, although not independent risk factors for HNC, may modify the risk of HNC associated with exposure to tobacco, alcohol, or HPV-HR. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/16324878/Head_and_neck_cancer_associated_with_herpes_simplex_virus_1_and_2_and_other_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(05)00237-X DB - PRIME DP - Unbound Medicine ER -