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Prognostic significance of high-risk HPV status in advanced cervical cancers and pelvic lymph nodes.
Gynecol Oncol. 2006 Mar; 100(3):570-8.GO

Abstract

OBJECTIVE

In this study, we investigated the presence of high-risk (HR) HPV types most prevalent in the Hungarian population in surgically removed cervical cancers and pelvic lymph nodes. The aim of our work was to determine the prognostic significance of HPV status in the lymph nodes draining the tumor.

METHODS

Primary tumor specimens from 150 patients and 900 lymph node samples (six per case) were studied. Fifty-six/150 were early (FIGO IA-IB) stage, while 94/150 were advanced (FIGO IIA-IIIB) stage cancers. Beside histopathological evaluation, DNA extracted from the tissue samples was subjected to nested PCR to detect characteristic type-specific sequences of HPVs 16, 18 and 33. Moreover, clinicopathological data were collected for an average 48-month postoperative follow-up period for the purposes of statistical analysis.

RESULTS

The presence of HR-HPV types in the lymph nodes shows no correlation with disease-free survival, whereas the presence of lymph node metastases significantly decreases life expectancy (P = 0.002). Lymph nodes with metastases more frequently carry HR-HPV than nodes with no evidence of tumorous infiltration (65% versus 36%, P < 0.001); however, a high number of metastases surrounding HR-HPV-positive tumors were found negative for the viruses (42/120).

CONCLUSIONS

HR-HPV status of pelvic lymph nodes draining cervical cancers has no noticeable influence on the life expectancy of the patients. HR-HPV-positive tumor cells do not necessarily have a selective advantage in forming metastases. Presumably, a number of alterations in cellular genes rather than the presence of papillomavirus DNA may have a decisive role in the progression of cervical cancers.

Authors+Show Affiliations

Molecular Pathology Research Group, Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University, Ulloi út 26, H-1085 Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16325245

Citation

Füle, Tibor, et al. "Prognostic Significance of High-risk HPV Status in Advanced Cervical Cancers and Pelvic Lymph Nodes." Gynecologic Oncology, vol. 100, no. 3, 2006, pp. 570-8.
Füle T, Csapó Z, Máthé M, et al. Prognostic significance of high-risk HPV status in advanced cervical cancers and pelvic lymph nodes. Gynecol Oncol. 2006;100(3):570-8.
Füle, T., Csapó, Z., Máthé, M., Tátrai, P., László, V., Papp, Z., & Kovalszky, I. (2006). Prognostic significance of high-risk HPV status in advanced cervical cancers and pelvic lymph nodes. Gynecologic Oncology, 100(3), 570-8.
Füle T, et al. Prognostic Significance of High-risk HPV Status in Advanced Cervical Cancers and Pelvic Lymph Nodes. Gynecol Oncol. 2006;100(3):570-8. PubMed PMID: 16325245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of high-risk HPV status in advanced cervical cancers and pelvic lymph nodes. AU - Füle,Tibor, AU - Csapó,Zsolt, AU - Máthé,Miklós, AU - Tátrai,Péter, AU - László,Viktória, AU - Papp,Zoltán, AU - Kovalszky,Ilona, Y1 - 2005/12/01/ PY - 2005/07/12/received PY - 2005/09/05/revised PY - 2005/09/12/accepted PY - 2005/12/6/pubmed PY - 2006/4/14/medline PY - 2005/12/6/entrez SP - 570 EP - 8 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 100 IS - 3 N2 - OBJECTIVE: In this study, we investigated the presence of high-risk (HR) HPV types most prevalent in the Hungarian population in surgically removed cervical cancers and pelvic lymph nodes. The aim of our work was to determine the prognostic significance of HPV status in the lymph nodes draining the tumor. METHODS: Primary tumor specimens from 150 patients and 900 lymph node samples (six per case) were studied. Fifty-six/150 were early (FIGO IA-IB) stage, while 94/150 were advanced (FIGO IIA-IIIB) stage cancers. Beside histopathological evaluation, DNA extracted from the tissue samples was subjected to nested PCR to detect characteristic type-specific sequences of HPVs 16, 18 and 33. Moreover, clinicopathological data were collected for an average 48-month postoperative follow-up period for the purposes of statistical analysis. RESULTS: The presence of HR-HPV types in the lymph nodes shows no correlation with disease-free survival, whereas the presence of lymph node metastases significantly decreases life expectancy (P = 0.002). Lymph nodes with metastases more frequently carry HR-HPV than nodes with no evidence of tumorous infiltration (65% versus 36%, P < 0.001); however, a high number of metastases surrounding HR-HPV-positive tumors were found negative for the viruses (42/120). CONCLUSIONS: HR-HPV status of pelvic lymph nodes draining cervical cancers has no noticeable influence on the life expectancy of the patients. HR-HPV-positive tumor cells do not necessarily have a selective advantage in forming metastases. Presumably, a number of alterations in cellular genes rather than the presence of papillomavirus DNA may have a decisive role in the progression of cervical cancers. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/16325245/Prognostic_significance_of_high_risk_HPV_status_in_advanced_cervical_cancers_and_pelvic_lymph_nodes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(05)00802-4 DB - PRIME DP - Unbound Medicine ER -