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Myosin heavy chain and fibre diameter of extrinsic tongue muscles in rhesus monkey.
Arch Oral Biol. 2006 Jun; 51(6):520-5.AO

Abstract

OBJECTIVE

The purpose of this investigation was to identify the myosin heavy chain (MHC) phenotype and fibre diameters of hypoglossal innervated extrinsic tongue muscles in rhesus monkey.

METHODS

Genioglossus, styloglossus and hyoglossus muscle samples obtained from three female rhesus monkeys were analysed for MHC isoforms via gel electrophoresis and stained with MHC antibodies to measure least mean diameters.

RESULTS

MHC phenotypes were consistent for all three muscles. Each muscle was predominantly composed of MHC type IIa and I. All three isoforms were significantly different from each other in fibre diameter for styloglossus and genioglossus (IIb>IIa and IIx>I; P<0.001). For hyoglossus, the MHC type II isoforms had larger diameters than the MHC type I isoform (P<0.001).

CONCLUSIONS

While the extrinsic tongue muscle MHC and/or muscle fibre type composition may be different between mammalian species, there are consistent similarities between the intrinsic and extrinsic tongue muscles. We suggest this is necessary for the highly coordinated activities performed by the tongue such as mastication, respiration and swallowing. The differences in fibre diameters among MHC isoforms suggest a large force gradation, which would be consistent with the coordination of these activities. The similarities among primates in MHC and/or muscle fibre composition as well as similar cortical inputs to the hypoglossal nucleus, suggest that we could expect to see similar MHC phenotype for extrinsic tongue muscles in human.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, Virginia Commonwealth University, P.O. Box 980709, Richmond, VA 23298-0709, USA. jcsmith@vcu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16325759

Citation

Smith, J Chadwick, et al. "Myosin Heavy Chain and Fibre Diameter of Extrinsic Tongue Muscles in Rhesus Monkey." Archives of Oral Biology, vol. 51, no. 6, 2006, pp. 520-5.
Smith JC, Goldberg SJ, Shall MS. Myosin heavy chain and fibre diameter of extrinsic tongue muscles in rhesus monkey. Arch Oral Biol. 2006;51(6):520-5.
Smith, J. C., Goldberg, S. J., & Shall, M. S. (2006). Myosin heavy chain and fibre diameter of extrinsic tongue muscles in rhesus monkey. Archives of Oral Biology, 51(6), 520-5.
Smith JC, Goldberg SJ, Shall MS. Myosin Heavy Chain and Fibre Diameter of Extrinsic Tongue Muscles in Rhesus Monkey. Arch Oral Biol. 2006;51(6):520-5. PubMed PMID: 16325759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myosin heavy chain and fibre diameter of extrinsic tongue muscles in rhesus monkey. AU - Smith,J Chadwick, AU - Goldberg,Stephen J, AU - Shall,Mary S, Y1 - 2005/12/01/ PY - 2005/07/05/received PY - 2005/10/04/revised PY - 2005/10/21/accepted PY - 2005/12/6/pubmed PY - 2007/2/21/medline PY - 2005/12/6/entrez SP - 520 EP - 5 JF - Archives of oral biology JO - Arch Oral Biol VL - 51 IS - 6 N2 - OBJECTIVE: The purpose of this investigation was to identify the myosin heavy chain (MHC) phenotype and fibre diameters of hypoglossal innervated extrinsic tongue muscles in rhesus monkey. METHODS: Genioglossus, styloglossus and hyoglossus muscle samples obtained from three female rhesus monkeys were analysed for MHC isoforms via gel electrophoresis and stained with MHC antibodies to measure least mean diameters. RESULTS: MHC phenotypes were consistent for all three muscles. Each muscle was predominantly composed of MHC type IIa and I. All three isoforms were significantly different from each other in fibre diameter for styloglossus and genioglossus (IIb>IIa and IIx>I; P<0.001). For hyoglossus, the MHC type II isoforms had larger diameters than the MHC type I isoform (P<0.001). CONCLUSIONS: While the extrinsic tongue muscle MHC and/or muscle fibre type composition may be different between mammalian species, there are consistent similarities between the intrinsic and extrinsic tongue muscles. We suggest this is necessary for the highly coordinated activities performed by the tongue such as mastication, respiration and swallowing. The differences in fibre diameters among MHC isoforms suggest a large force gradation, which would be consistent with the coordination of these activities. The similarities among primates in MHC and/or muscle fibre composition as well as similar cortical inputs to the hypoglossal nucleus, suggest that we could expect to see similar MHC phenotype for extrinsic tongue muscles in human. SN - 0003-9969 UR - https://www.unboundmedicine.com/medline/citation/16325759/Myosin_heavy_chain_and_fibre_diameter_of_extrinsic_tongue_muscles_in_rhesus_monkey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(05)00262-1 DB - PRIME DP - Unbound Medicine ER -