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RETRACTED ARTICLE

Cardiovascular dysautonomia in de novo Parkinson's disease.
J Neurol Sci. 2006 Feb 15; 241(1-2):59-65.JN

Abstract

BACKGROUND

Clinical symptoms of Parkinson's disease (PD) include not only motor distress, but also autonomic dysfunction.

OBJECTIVE

To clarify the progression of autonomic nervous dysfunction in PD.

METHODS

The subjects were 44 patients with de novo PD. Autonomic nervous function, including cardiac sympathetic gain, was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure.

RESULTS

Decreased cardiac MIBG uptake was found even in patients with early stage PD. MIBG uptake gradually decreased with increased disease severity. Hemodynamic studies using the Valsalva maneuver revealed that patients with early stage PD had reduced baroreceptor reflex sensitivity (BRS) in phase II, but not phase IV. Blood pressures normally rose in phases II and IV, but the increments decreased with disease progression. In early stage PD, the low frequency power of the RR interval (RR-LF) and the ratio (LF/HF) of RR-LF to the high frequency component of the RR interval (RR-HF) were significantly lower than the respective control values, despite no significant difference in RR-HF; these variables decreased with disease progression.

CONCLUSION

Our results show that latent sympathetic nervous dysfunction without parasympathetic dysfunction, especially that involving the sinus node, is already present in early stage de novo PD. It is unclear whether the responsible lesion is central or peripheral.

Authors+Show Affiliations

Department of Neurology, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan. h.oka@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Retracted Publication

Language

eng

PubMed ID

16325862

Citation

Oka, Hisayoshi, et al. "Cardiovascular Dysautonomia in De Novo Parkinson's Disease." Journal of the Neurological Sciences, vol. 241, no. 1-2, 2006, pp. 59-65.
Oka H, Mochio S, Onouchi K, et al. Cardiovascular dysautonomia in de novo Parkinson's disease. J Neurol Sci. 2006;241(1-2):59-65.
Oka, H., Mochio, S., Onouchi, K., Morita, M., Yoshioka, M., & Inoue, K. (2006). Cardiovascular dysautonomia in de novo Parkinson's disease. Journal of the Neurological Sciences, 241(1-2), 59-65.
Oka H, et al. Cardiovascular Dysautonomia in De Novo Parkinson's Disease. J Neurol Sci. 2006 Feb 15;241(1-2):59-65. PubMed PMID: 16325862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular dysautonomia in de novo Parkinson's disease. AU - Oka,Hisayoshi, AU - Mochio,Soichiro, AU - Onouchi,Kenji, AU - Morita,Masayo, AU - Yoshioka,Masayuki, AU - Inoue,Kiyoharu, Y1 - 2005/12/02/ PY - 2005/05/16/received PY - 2005/10/19/revised PY - 2005/10/24/accepted PY - 2005/12/6/pubmed PY - 2006/4/28/medline PY - 2005/12/6/entrez SP - 59 EP - 65 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 241 IS - 1-2 N2 - BACKGROUND: Clinical symptoms of Parkinson's disease (PD) include not only motor distress, but also autonomic dysfunction. OBJECTIVE: To clarify the progression of autonomic nervous dysfunction in PD. METHODS: The subjects were 44 patients with de novo PD. Autonomic nervous function, including cardiac sympathetic gain, was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure. RESULTS: Decreased cardiac MIBG uptake was found even in patients with early stage PD. MIBG uptake gradually decreased with increased disease severity. Hemodynamic studies using the Valsalva maneuver revealed that patients with early stage PD had reduced baroreceptor reflex sensitivity (BRS) in phase II, but not phase IV. Blood pressures normally rose in phases II and IV, but the increments decreased with disease progression. In early stage PD, the low frequency power of the RR interval (RR-LF) and the ratio (LF/HF) of RR-LF to the high frequency component of the RR interval (RR-HF) were significantly lower than the respective control values, despite no significant difference in RR-HF; these variables decreased with disease progression. CONCLUSION: Our results show that latent sympathetic nervous dysfunction without parasympathetic dysfunction, especially that involving the sinus node, is already present in early stage de novo PD. It is unclear whether the responsible lesion is central or peripheral. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/16325862/Cardiovascular_dysautonomia_in_de_novo_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -