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Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine.
Trans R Soc Trop Med Hyg. 2006 Jul; 100(7):698-700.TR

Abstract

We report the case of a patient with Indian post-kala-azar dermal leishmaniasis (PKDL) who failed to show any response to 2 months' treatment with sodium stibogluconate. Six months later he was treated with oral miltefosine on a compassionate basis as an off-label indication. Miltefosine was given 100mg daily in divided doses for an initial 8 weeks. Due to insufficient response, the treatment was extended up to a total of 12 weeks. The patient showed an excellent response to treatment, and after 12 months of follow-up there was complete healing of all cutaneous lesions. Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed.

Links

Publisher Full Text
linkinghub.elsevier.com
academic.oup.com

Authors+Show Affiliations

Sundar S
Kala-azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. shyam_vns@sify.com
Kumar K
No affiliation info available
Chakravarty J
No affiliation info available
Agrawal D
No affiliation info available
Agrawal S
No affiliation info available
Chhabra A
No affiliation info available
Singh V
No affiliation info available

MeSH

Administration, OralAdultAntimony Sodium GluconateAntiprotozoal AgentsHumansInjections, IntravenousLeishmaniasis, CutaneousLeishmaniasis, VisceralMalePhosphorylcholineTreatment Outcome

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16325873

Citation

Sundar, Shyam, et al. "Cure of Antimony-unresponsive Indian Post-kala-azar Dermal Leishmaniasis With Oral Miltefosine." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 7, 2006, pp. 698-700.
Sundar S, Kumar K, Chakravarty J, et al. Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine. Trans R Soc Trop Med Hyg. 2006;100(7):698-700.
Sundar, S., Kumar, K., Chakravarty, J., Agrawal, D., Agrawal, S., Chhabra, A., & Singh, V. (2006). Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(7), 698-700.
Sundar S, et al. Cure of Antimony-unresponsive Indian Post-kala-azar Dermal Leishmaniasis With Oral Miltefosine. Trans R Soc Trop Med Hyg. 2006;100(7):698-700. PubMed PMID: 16325873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine. AU - Sundar,Shyam, AU - Kumar,Kailash, AU - Chakravarty,Jaya, AU - Agrawal,Dipti, AU - Agrawal,Shrinkhla, AU - Chhabra,Amit, AU - Singh,Vikram, Y1 - 2005/12/02/ PY - 2005/06/01/received PY - 2005/08/04/revised PY - 2005/09/05/accepted PY - 2005/12/6/pubmed PY - 2006/9/22/medline PY - 2005/12/6/entrez SP - 698 EP - 700 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 100 IS - 7 N2 - We report the case of a patient with Indian post-kala-azar dermal leishmaniasis (PKDL) who failed to show any response to 2 months' treatment with sodium stibogluconate. Six months later he was treated with oral miltefosine on a compassionate basis as an off-label indication. Miltefosine was given 100mg daily in divided doses for an initial 8 weeks. Due to insufficient response, the treatment was extended up to a total of 12 weeks. The patient showed an excellent response to treatment, and after 12 months of follow-up there was complete healing of all cutaneous lesions. Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/16325873/Cure_of_antimony_unresponsive_Indian_post_kala_azar_dermal_leishmaniasis_with_oral_miltefosine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(05)00371-8 DB - PRIME DP - Unbound Medicine ER -