Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine.Trans R Soc Trop Med Hyg. 2006 Jul; 100(7):698-700.TR
Abstract
We report the case of a patient with Indian post-kala-azar dermal leishmaniasis (PKDL) who failed to show any response to 2 months' treatment with sodium stibogluconate. Six months later he was treated with oral miltefosine on a compassionate basis as an off-label indication. Miltefosine was given 100mg daily in divided doses for an initial 8 weeks. Due to insufficient response, the treatment was extended up to a total of 12 weeks. The patient showed an excellent response to treatment, and after 12 months of follow-up there was complete healing of all cutaneous lesions. Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed.
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Publisher Full Text
MeSH
Pub Type(s)
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
16325873
Citation
Sundar, Shyam, et al. "Cure of Antimony-unresponsive Indian Post-kala-azar Dermal Leishmaniasis With Oral Miltefosine." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 7, 2006, pp. 698-700.
Sundar S, Kumar K, Chakravarty J, et al. Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine. Trans R Soc Trop Med Hyg. 2006;100(7):698-700.
Sundar, S., Kumar, K., Chakravarty, J., Agrawal, D., Agrawal, S., Chhabra, A., & Singh, V. (2006). Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(7), 698-700.
Sundar S, et al. Cure of Antimony-unresponsive Indian Post-kala-azar Dermal Leishmaniasis With Oral Miltefosine. Trans R Soc Trop Med Hyg. 2006;100(7):698-700. PubMed PMID: 16325873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine.
AU - Sundar,Shyam,
AU - Kumar,Kailash,
AU - Chakravarty,Jaya,
AU - Agrawal,Dipti,
AU - Agrawal,Shrinkhla,
AU - Chhabra,Amit,
AU - Singh,Vikram,
Y1 - 2005/12/02/
PY - 2005/06/01/received
PY - 2005/08/04/revised
PY - 2005/09/05/accepted
PY - 2005/12/6/pubmed
PY - 2006/9/22/medline
PY - 2005/12/6/entrez
SP - 698
EP - 700
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
JO - Trans R Soc Trop Med Hyg
VL - 100
IS - 7
N2 - We report the case of a patient with Indian post-kala-azar dermal leishmaniasis (PKDL) who failed to show any response to 2 months' treatment with sodium stibogluconate. Six months later he was treated with oral miltefosine on a compassionate basis as an off-label indication. Miltefosine was given 100mg daily in divided doses for an initial 8 weeks. Due to insufficient response, the treatment was extended up to a total of 12 weeks. The patient showed an excellent response to treatment, and after 12 months of follow-up there was complete healing of all cutaneous lesions. Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed.
SN - 0035-9203
UR - https://www.unboundmedicine.com/medline/citation/16325873/Cure_of_antimony_unresponsive_Indian_post_kala_azar_dermal_leishmaniasis_with_oral_miltefosine_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(05)00371-8
DB - PRIME
DP - Unbound Medicine
ER -