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The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior.
Neuroscience. 2006 Feb; 137(3):961-70.N

Abstract

A number of rat neuropathy models have been developed to simulate human neuropathic pain conditions, such as spontaneous pain, hyperalgesia, and allodynia. In the present study, to determine the relative importance of injury site (proximal or distal to the primary afferent neurons) and injury type (motor or sensory), we examined pain-related behaviors and changes of brain-derived neurotrophic factor expression in the dorsal root ganglion in sham-operated rats, and in the L5 dorsal rhizotomy, L5 ventral rhizotomy, L5 dorsal rhizotomy+ventral rhizotomy, and L5 spinal nerve transection models. L5 ventral rhizotomy and spinal nerve transection produced not only mechanical and heat hypersensitivity, but also an increase in brain-derived neurotrophic factor mRNA/protein in the L5 dorsal root ganglion at 7 days after surgery. In contrast, rats in the L5 dorsal rhizotomy and dorsal rhizotomy+ventral rhizotomy groups did not show both pain behaviors at 7 days after surgery, despite brain-derived neurotrophic factor upregulation in medium- and large-size neurons in the L5 dorsal root ganglion. On the other hand, L5 spinal nerve transection, but not dorsal rhizotomy, dorsal rhizotomy+ventral rhizotomy or ventral rhizotomy, increased the expression of brain-derived neurotrophic factor in the L4 dorsal root ganglion at 7 days after surgery. Taken together, these findings suggest that the upregulation of brain-derived neurotrophic factor expression in the L4 and L5 dorsal root ganglion neurons may be, at least in part, involved in the pathophysiological mechanisms of neuropathic pain and that the selective nerve root injury models may be useful for studying the underlying mechanisms of chronic pain after nerve injury.

Authors+Show Affiliations

Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16326015

Citation

Obata, K, et al. "The Effect of Site and Type of Nerve Injury On the Expression of Brain-derived Neurotrophic Factor in the Dorsal Root Ganglion and On Neuropathic Pain Behavior." Neuroscience, vol. 137, no. 3, 2006, pp. 961-70.
Obata K, Yamanaka H, Kobayashi K, et al. The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior. Neuroscience. 2006;137(3):961-70.
Obata, K., Yamanaka, H., Kobayashi, K., Dai, Y., Mizushima, T., Katsura, H., Fukuoka, T., Tokunaga, A., & Noguchi, K. (2006). The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior. Neuroscience, 137(3), 961-70.
Obata K, et al. The Effect of Site and Type of Nerve Injury On the Expression of Brain-derived Neurotrophic Factor in the Dorsal Root Ganglion and On Neuropathic Pain Behavior. Neuroscience. 2006;137(3):961-70. PubMed PMID: 16326015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior. AU - Obata,K, AU - Yamanaka,H, AU - Kobayashi,K, AU - Dai,Y, AU - Mizushima,T, AU - Katsura,H, AU - Fukuoka,T, AU - Tokunaga,A, AU - Noguchi,K, Y1 - 2005/12/02/ PY - 2005/04/18/received PY - 2005/10/03/revised PY - 2005/10/07/accepted PY - 2005/12/6/pubmed PY - 2006/4/13/medline PY - 2005/12/6/entrez SP - 961 EP - 70 JF - Neuroscience JO - Neuroscience VL - 137 IS - 3 N2 - A number of rat neuropathy models have been developed to simulate human neuropathic pain conditions, such as spontaneous pain, hyperalgesia, and allodynia. In the present study, to determine the relative importance of injury site (proximal or distal to the primary afferent neurons) and injury type (motor or sensory), we examined pain-related behaviors and changes of brain-derived neurotrophic factor expression in the dorsal root ganglion in sham-operated rats, and in the L5 dorsal rhizotomy, L5 ventral rhizotomy, L5 dorsal rhizotomy+ventral rhizotomy, and L5 spinal nerve transection models. L5 ventral rhizotomy and spinal nerve transection produced not only mechanical and heat hypersensitivity, but also an increase in brain-derived neurotrophic factor mRNA/protein in the L5 dorsal root ganglion at 7 days after surgery. In contrast, rats in the L5 dorsal rhizotomy and dorsal rhizotomy+ventral rhizotomy groups did not show both pain behaviors at 7 days after surgery, despite brain-derived neurotrophic factor upregulation in medium- and large-size neurons in the L5 dorsal root ganglion. On the other hand, L5 spinal nerve transection, but not dorsal rhizotomy, dorsal rhizotomy+ventral rhizotomy or ventral rhizotomy, increased the expression of brain-derived neurotrophic factor in the L4 dorsal root ganglion at 7 days after surgery. Taken together, these findings suggest that the upregulation of brain-derived neurotrophic factor expression in the L4 and L5 dorsal root ganglion neurons may be, at least in part, involved in the pathophysiological mechanisms of neuropathic pain and that the selective nerve root injury models may be useful for studying the underlying mechanisms of chronic pain after nerve injury. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16326015/The_effect_of_site_and_type_of_nerve_injury_on_the_expression_of_brain_derived_neurotrophic_factor_in_the_dorsal_root_ganglion_and_on_neuropathic_pain_behavior_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(05)01161-9 DB - PRIME DP - Unbound Medicine ER -