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A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.
Acta Neuropathol 2006; 111(1):15-20AN

Abstract

It is presently unclear whether polymorphic variations in the oxidized low-density lipoprotein receptor 1 (OLR1), or low-density lipoprotein receptor-related protein 1 (LRP1), genes act as risk factors for Alzheimer's disease (AD). In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1 +1071 and +1073 polymorphisms and LRP1 C766T polymorphism in patients with AD There was an increased Abeta40 load as CAA, but not as SP, in frontal cortex of AD patients carrying OLR1+1073 CC genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele. No differences in total Abeta or Abeta42 load as CAA or SP between OLR1+1073 genotypes was seen, nor were there any differences between OLR1+1071 and LRP1 genotypes for any measure of Abeta. Present data suggests that homozygosity for the C allele for OLR1+1073 polymorphism, selectively in individuals without APOE epsilon4 allele, may impair clearance of Abeta, and particularly Abeta40, from the brain across the blood-brain barrier, leading to its 'diversion' into perivascular drainage channels, thereby increasing the severity of CAA in such persons.

Authors+Show Affiliations

Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, M6 8HD, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16328515

Citation

Shi, Jing, et al. "A 3'-UTR Polymorphism in the Oxidized LDL Receptor 1 Gene Increases Abeta40 Load as Cerebral Amyloid Angiopathy in Alzheimer's Disease." Acta Neuropathologica, vol. 111, no. 1, 2006, pp. 15-20.
Shi J, Tian J, Pritchard A, et al. A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathol. 2006;111(1):15-20.
Shi, J., Tian, J., Pritchard, A., Lendon, C., Lambert, J. C., Iwatsubo, T., & Mann, D. M. (2006). A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathologica, 111(1), pp. 15-20.
Shi J, et al. A 3'-UTR Polymorphism in the Oxidized LDL Receptor 1 Gene Increases Abeta40 Load as Cerebral Amyloid Angiopathy in Alzheimer's Disease. Acta Neuropathol. 2006;111(1):15-20. PubMed PMID: 16328515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. AU - Shi,Jing, AU - Tian,Jinzhou, AU - Pritchard,Antonia, AU - Lendon,Corinne, AU - Lambert,Jean-Charles, AU - Iwatsubo,Takeshi, AU - Mann,David M A, Y1 - 2005/11/22/ PY - 2005/08/19/received PY - 2005/09/07/accepted PY - 2005/09/07/revised PY - 2005/12/6/pubmed PY - 2006/7/28/medline PY - 2005/12/6/entrez SP - 15 EP - 20 JF - Acta neuropathologica JO - Acta Neuropathol. VL - 111 IS - 1 N2 - It is presently unclear whether polymorphic variations in the oxidized low-density lipoprotein receptor 1 (OLR1), or low-density lipoprotein receptor-related protein 1 (LRP1), genes act as risk factors for Alzheimer's disease (AD). In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1 +1071 and +1073 polymorphisms and LRP1 C766T polymorphism in patients with AD There was an increased Abeta40 load as CAA, but not as SP, in frontal cortex of AD patients carrying OLR1+1073 CC genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele. No differences in total Abeta or Abeta42 load as CAA or SP between OLR1+1073 genotypes was seen, nor were there any differences between OLR1+1071 and LRP1 genotypes for any measure of Abeta. Present data suggests that homozygosity for the C allele for OLR1+1073 polymorphism, selectively in individuals without APOE epsilon4 allele, may impair clearance of Abeta, and particularly Abeta40, from the brain across the blood-brain barrier, leading to its 'diversion' into perivascular drainage channels, thereby increasing the severity of CAA in such persons. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/16328515/A_3'_UTR_polymorphism_in_the_oxidized_LDL_receptor_1_gene_increases_Abeta40_load_as_cerebral_amyloid_angiopathy_in_Alzheimer's_disease_ L2 - https://dx.doi.org/10.1007/s00401-005-1108-3 DB - PRIME DP - Unbound Medicine ER -