Tags

Type your tag names separated by a space and hit enter

A nationwide epidemiologic study of breast cancer incidence following breast reduction surgery in a large cohort of Swedish women.
Breast Cancer Res Treat. 2006 May; 97(2):131-4.BC

Abstract

While it has been demonstrated that prophylactic mastectomy reduces breast cancer incidence among women at high risk, many women often consider this disfiguring surgery unacceptable. One alternative approach may be breast reduction surgery. In order to evaluate the long-term incidence of breast cancer following surgical removal of breast tissue, we have extended by 9 years the follow-up period of our earlier retrospective cohort study of Swedish women electing cosmetic breast reduction surgery (n=30,444) between 1965 and 1993, yielding an average of nearly 16 years of follow-up. Cancer incidence through 2002 was ascertained via the Swedish Cancer Registry. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated comparing women who underwent breast reduction surgery with women in the general Swedish population. Breast cancer was observed in 443 women versus 624 expected for a statistically significant reduced SIR of 0.71 (95% CI=0.65-0.78). Analyses by age at surgery, time since surgery or calendar year of surgery revealed similar reductions in risk. Our study of over 30,000 women with long-term follow-up offers further evidence that women undergoing breast reduction surgery have reduced breast cancer risk. As the evidence from large-scale cohort studies accumulates, direct testing of this reduction in risk through clinical trials should be considered.

Authors+Show Affiliations

Department of Medicine, International Epidemiology Institute, Rockville, MD 20850, USA. jon.p.fryzek@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16328720

Citation

Fryzek, Jon P., et al. "A Nationwide Epidemiologic Study of Breast Cancer Incidence Following Breast Reduction Surgery in a Large Cohort of Swedish Women." Breast Cancer Research and Treatment, vol. 97, no. 2, 2006, pp. 131-4.
Fryzek JP, Ye W, Nyrén O, et al. A nationwide epidemiologic study of breast cancer incidence following breast reduction surgery in a large cohort of Swedish women. Breast Cancer Res Treat. 2006;97(2):131-4.
Fryzek, J. P., Ye, W., Nyrén, O., Tarone, R. E., Lipworth, L., & McLaughlin, J. K. (2006). A nationwide epidemiologic study of breast cancer incidence following breast reduction surgery in a large cohort of Swedish women. Breast Cancer Research and Treatment, 97(2), 131-4.
Fryzek JP, et al. A Nationwide Epidemiologic Study of Breast Cancer Incidence Following Breast Reduction Surgery in a Large Cohort of Swedish Women. Breast Cancer Res Treat. 2006;97(2):131-4. PubMed PMID: 16328720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide epidemiologic study of breast cancer incidence following breast reduction surgery in a large cohort of Swedish women. AU - Fryzek,Jon P, AU - Ye,Weimin, AU - Nyrén,Olof, AU - Tarone,Robert E, AU - Lipworth,Loren, AU - McLaughlin,Joseph K, Y1 - 2005/12/03/ PY - 2005/10/06/received PY - 2005/10/06/accepted PY - 2005/12/6/pubmed PY - 2006/11/15/medline PY - 2005/12/6/entrez SP - 131 EP - 4 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 97 IS - 2 N2 - While it has been demonstrated that prophylactic mastectomy reduces breast cancer incidence among women at high risk, many women often consider this disfiguring surgery unacceptable. One alternative approach may be breast reduction surgery. In order to evaluate the long-term incidence of breast cancer following surgical removal of breast tissue, we have extended by 9 years the follow-up period of our earlier retrospective cohort study of Swedish women electing cosmetic breast reduction surgery (n=30,444) between 1965 and 1993, yielding an average of nearly 16 years of follow-up. Cancer incidence through 2002 was ascertained via the Swedish Cancer Registry. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated comparing women who underwent breast reduction surgery with women in the general Swedish population. Breast cancer was observed in 443 women versus 624 expected for a statistically significant reduced SIR of 0.71 (95% CI=0.65-0.78). Analyses by age at surgery, time since surgery or calendar year of surgery revealed similar reductions in risk. Our study of over 30,000 women with long-term follow-up offers further evidence that women undergoing breast reduction surgery have reduced breast cancer risk. As the evidence from large-scale cohort studies accumulates, direct testing of this reduction in risk through clinical trials should be considered. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/16328720/A_nationwide_epidemiologic_study_of_breast_cancer_incidence_following_breast_reduction_surgery_in_a_large_cohort_of_Swedish_women_ DB - PRIME DP - Unbound Medicine ER -