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Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment.
Hum Psychopharmacol. 2006 Jan; 21(1):53-9.HP

Abstract

OBJECTIVE

In the present study, we aimed to investigate whether nitric oxide (NO) levels and activities of xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) are associated with Panic disorder (PD) as well as impact of psychopharmacological treatments on NO, SOD, ADA, and XO levels in PD.

METHOD

In this study, 32 patients and 20 healthy controls were included. The serum levels of NO, XO, SOD, and ADA were measured in the patients and controls. The patients were treated with antidepressant.

RESULTS

ADA and XO levels of the patients were significantly higher than the controls. SOD levels of the patients were significantly lower than the controls but the difference was not statistically significant. Although NO levels of the patients were higher than the controls, the difference was not statistically significant. There was no correlation between PAS and the parameters studied (SOD, ADA, XO, and NO) of the patients. After 8 weeks of antidepressant treatment, ADA and SOD activities were increased whereas NO and XO levels decreased significantly.

CONCLUSION

ADA, XO activity may have a pathophysiological role in PD, and prognosis of PD. Activity of these enzymes may be used to monitor effects of the antidepressant treatment.

Authors+Show Affiliations

Department of Psychiatry, Medical Faculty of Gaziantep University, Turkey. hasanherken@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

16329160

Citation

Herken, Hasan, et al. "Nitric Oxide, Adenosine Deaminase, Xanthine Oxidase and Superoxide Dismutase in Patients With Panic Disorder: Alterations By Antidepressant Treatment." Human Psychopharmacology, vol. 21, no. 1, 2006, pp. 53-9.
Herken H, Akyol O, Yilmaz HR, et al. Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment. Hum Psychopharmacol. 2006;21(1):53-9.
Herken, H., Akyol, O., Yilmaz, H. R., Tutkun, H., Savas, H. A., Ozen, M. E., Kalenderoglu, A., & Gulec, M. (2006). Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment. Human Psychopharmacology, 21(1), 53-9.
Herken H, et al. Nitric Oxide, Adenosine Deaminase, Xanthine Oxidase and Superoxide Dismutase in Patients With Panic Disorder: Alterations By Antidepressant Treatment. Hum Psychopharmacol. 2006;21(1):53-9. PubMed PMID: 16329160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment. AU - Herken,Hasan, AU - Akyol,Omer, AU - Yilmaz,H Ramazan, AU - Tutkun,Hamdi, AU - Savas,Haluk A, AU - Ozen,M Eren, AU - Kalenderoglu,Aysun, AU - Gulec,Mukaddes, PY - 2005/12/6/pubmed PY - 2006/5/26/medline PY - 2005/12/6/entrez SP - 53 EP - 9 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 21 IS - 1 N2 - OBJECTIVE: In the present study, we aimed to investigate whether nitric oxide (NO) levels and activities of xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) are associated with Panic disorder (PD) as well as impact of psychopharmacological treatments on NO, SOD, ADA, and XO levels in PD. METHOD: In this study, 32 patients and 20 healthy controls were included. The serum levels of NO, XO, SOD, and ADA were measured in the patients and controls. The patients were treated with antidepressant. RESULTS: ADA and XO levels of the patients were significantly higher than the controls. SOD levels of the patients were significantly lower than the controls but the difference was not statistically significant. Although NO levels of the patients were higher than the controls, the difference was not statistically significant. There was no correlation between PAS and the parameters studied (SOD, ADA, XO, and NO) of the patients. After 8 weeks of antidepressant treatment, ADA and SOD activities were increased whereas NO and XO levels decreased significantly. CONCLUSION: ADA, XO activity may have a pathophysiological role in PD, and prognosis of PD. Activity of these enzymes may be used to monitor effects of the antidepressant treatment. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/16329160/Nitric_oxide_adenosine_deaminase_xanthine_oxidase_and_superoxide_dismutase_in_patients_with_panic_disorder:_alterations_by_antidepressant_treatment_ L2 - https://doi.org/10.1002/hup.742 DB - PRIME DP - Unbound Medicine ER -