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A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxy-enhanced polyurethane membrane.
Biosens Bioelectron. 2006 Jun 15; 21(12):2275-82.BB

Abstract

This paper describes the preparation method as well as the in vitro and in vivo evaluation of a novel flexible glucose biosensor designed for long-term subcutaneous implantation. An epoxy-enhanced polyurethane membrane, which includes ca. 30-40% epoxy resin adhesive and 50-70% polyurethane, has been developed and used for the first time as the outer protective membrane of the sensor. This new membrane was developed to increase the in vivo durability and lifetime of implantable biosensors. This epoxy-polyurethane membrane was shown to be porous and is of excellent durability. A sensor with such a membrane shows excellent long-term stability and can last for 4-8 months in solutions at room temperature. To verify the in vivo performance of the sensor, nine sensors were implanted in three rats and tested regularly. Eight sensors kept functioning well in the rats for 10-56 days. The ninth sensor was damaged during implantation. All original sensitivity data as well as four response curves obtained at days 7, 17, 52 and 56, respectively are presented.

Authors+Show Affiliations

Department of Chemical Engineering, University of South Florida, 4202 E. Fowler Avenue, ENB 118, Tampa, FL 33620-5350, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

16330201

Citation

Yu, Bazhang, et al. "A Long-term Flexible Minimally-invasive Implantable Glucose Biosensor Based On an Epoxy-enhanced Polyurethane Membrane." Biosensors & Bioelectronics, vol. 21, no. 12, 2006, pp. 2275-82.
Yu B, Long N, Moussy Y, et al. A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxy-enhanced polyurethane membrane. Biosens Bioelectron. 2006;21(12):2275-82.
Yu, B., Long, N., Moussy, Y., & Moussy, F. (2006). A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxy-enhanced polyurethane membrane. Biosensors & Bioelectronics, 21(12), 2275-82.
Yu B, et al. A Long-term Flexible Minimally-invasive Implantable Glucose Biosensor Based On an Epoxy-enhanced Polyurethane Membrane. Biosens Bioelectron. 2006 Jun 15;21(12):2275-82. PubMed PMID: 16330201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxy-enhanced polyurethane membrane. AU - Yu,Bazhang, AU - Long,Nathan, AU - Moussy,Yvonne, AU - Moussy,Francis, Y1 - 2005/12/05/ PY - 2005/07/19/received PY - 2005/10/17/revised PY - 2005/11/03/accepted PY - 2005/12/7/pubmed PY - 2006/7/18/medline PY - 2005/12/7/entrez SP - 2275 EP - 82 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 21 IS - 12 N2 - This paper describes the preparation method as well as the in vitro and in vivo evaluation of a novel flexible glucose biosensor designed for long-term subcutaneous implantation. An epoxy-enhanced polyurethane membrane, which includes ca. 30-40% epoxy resin adhesive and 50-70% polyurethane, has been developed and used for the first time as the outer protective membrane of the sensor. This new membrane was developed to increase the in vivo durability and lifetime of implantable biosensors. This epoxy-polyurethane membrane was shown to be porous and is of excellent durability. A sensor with such a membrane shows excellent long-term stability and can last for 4-8 months in solutions at room temperature. To verify the in vivo performance of the sensor, nine sensors were implanted in three rats and tested regularly. Eight sensors kept functioning well in the rats for 10-56 days. The ninth sensor was damaged during implantation. All original sensitivity data as well as four response curves obtained at days 7, 17, 52 and 56, respectively are presented. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/16330201/A_long_term_flexible_minimally_invasive_implantable_glucose_biosensor_based_on_an_epoxy_enhanced_polyurethane_membrane_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(05)00354-4 DB - PRIME DP - Unbound Medicine ER -