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Association of 4G/5G polymorphism in PAI1 promoter with PAI1 level in deep vein thrombosis.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Dec; 22(6):624-7.ZY

Abstract

OBJECTIVE

To reveal the association of 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor 1 gene (PAI1) with plasma PAI1 level in deep vein thrombosis (DVT) in Chinese Han ethnic group.

METHODS

One hundred and twenty Chinese DVT patients and 120 healthy controls were recruited. The PAI1 promoter 4G/5G polymorphism was detected using polymerase chain reaction (PCR). The antigen of tissue-type plasminogen activator (tPA) or PAI1 was quantified by a commercially available enzyme-linked immunosorbent assay (ELISA) in DVT cases and health controlsì respectively.

RESULTS

Neither in the distribution of PAI1 promoter 4G/5G polymorphism nor in the frequencies of 4G and 5G allele was there a difference between two groups. The levels of PAI1 antigen in the carriers of the 4G/4G genotype were significantly higher than those either in the 4G/5G genotype or in the 5G/5G genotype; In the 4G/5G genotype or in the 5G/5G genotype the TG levels are an independently determinant factor of PAI1 antigen levels.

CONCLUSION

There is a close relationship of the PAI1 4G/5G polymorphism to its plasma level in deep vein thrombosis in Chinese Han ethnic group, although lack of association between this genetic variation and risk of DVT suggest no major cause-effect pathogenic role of this polymorphism by itself.

Authors+Show Affiliations

Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin, P. R. China. chenyongli555@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16331557

Citation

Chen, Yong-li, et al. "Association of 4G/5G Polymorphism in PAI1 Promoter With PAI1 Level in Deep Vein Thrombosis." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 22, no. 6, 2005, pp. 624-7.
Chen YL, Zhang JX, Wang PX, et al. Association of 4G/5G polymorphism in PAI1 promoter with PAI1 level in deep vein thrombosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(6):624-7.
Chen, Y. L., Zhang, J. X., Wang, P. X., Cui, R. Z., Zhao, F. M., Mao, Y. M., Li, J. Y., Bi, Y. Y., & Li, H. (2005). Association of 4G/5G polymorphism in PAI1 promoter with PAI1 level in deep vein thrombosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 22(6), 624-7.
Chen YL, et al. Association of 4G/5G Polymorphism in PAI1 Promoter With PAI1 Level in Deep Vein Thrombosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(6):624-7. PubMed PMID: 16331557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of 4G/5G polymorphism in PAI1 promoter with PAI1 level in deep vein thrombosis. AU - Chen,Yong-li, AU - Zhang,Jing-xia, AU - Wang,Pei-xian, AU - Cui,Rang-zhuang, AU - Zhao,Fu-mei, AU - Mao,Yong-min, AU - Li,Jing-yan, AU - Bi,Yan-yong, AU - Li,Hui, PY - 2005/12/7/pubmed PY - 2009/3/20/medline PY - 2005/12/7/entrez SP - 624 EP - 7 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 22 IS - 6 N2 - OBJECTIVE: To reveal the association of 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor 1 gene (PAI1) with plasma PAI1 level in deep vein thrombosis (DVT) in Chinese Han ethnic group. METHODS: One hundred and twenty Chinese DVT patients and 120 healthy controls were recruited. The PAI1 promoter 4G/5G polymorphism was detected using polymerase chain reaction (PCR). The antigen of tissue-type plasminogen activator (tPA) or PAI1 was quantified by a commercially available enzyme-linked immunosorbent assay (ELISA) in DVT cases and health controlsì respectively. RESULTS: Neither in the distribution of PAI1 promoter 4G/5G polymorphism nor in the frequencies of 4G and 5G allele was there a difference between two groups. The levels of PAI1 antigen in the carriers of the 4G/4G genotype were significantly higher than those either in the 4G/5G genotype or in the 5G/5G genotype; In the 4G/5G genotype or in the 5G/5G genotype the TG levels are an independently determinant factor of PAI1 antigen levels. CONCLUSION: There is a close relationship of the PAI1 4G/5G polymorphism to its plasma level in deep vein thrombosis in Chinese Han ethnic group, although lack of association between this genetic variation and risk of DVT suggest no major cause-effect pathogenic role of this polymorphism by itself. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/16331557/Association_of_4G/5G_polymorphism_in_PAI1_promoter_with_PAI1_level_in_deep_vein_thrombosis_ DB - PRIME DP - Unbound Medicine ER -