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[Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Dec; 22(6):691-3.ZY

Abstract

OBJECTIVE

To investigate the association of activated coagulation factor VII(F7a) and its gene Msp I polymorphism with coronary heart disease in elderly patients.

METHODS

This was a case-control study, and the method of candidate gene was adopted. F7 genotypes were identified with polymerase chain reaction amplified genomic deoxyribonulieic acid (DNA) and Msp I restriction fragment length polymorphism analysis, and the level of plasma F7a was detected with recombinant tissue factor method for 108 elderly patients with coronary heart disease and 120 sex- and age-matched healthy control subjects.

RESULTS

(1) Plasma F7a levels was significantly higher in elderly patients with coronary heart disease than in healthy control subjects (2.88 +/- 0.62 vs 2.58 +/- 0.60 microg/L, P < 0.05), and was significantly higher in old myocardial infarction than in stable angina pectoris (3.12 +/- 0.62 vs 2.76 +/- 0.60, P < 0.05). F7a was shown to be a risk factor for coronary heart disease in elderly patients by Logistic regression analysis (OR=1.21 P < 0.05). (2) The allelic frequencies were in accordance with Hardy-Weinberg equilibrium. The results suggested that the distribution of genotype and allelic frequencies in the groups displayed no significant difference, and there was no difference between the subgroups of coronary heart disease in elderly patients, either (P > 0.05). (3) F7a level was significantly higher in RR genotype than in Q allele carriers (2.72 +/- 0.60 vs 1.98 +/- 0.59 microg/L, P < 0.05) and was associated with F7 gene polymorphism.

CONCLUSION

Plasma F7a level may be an independent risk factor of coronary heart disease in elderly patients, and it may be influenced by the Msp I polymorphism of F7 gene.

Authors+Show Affiliations

Department of Cardiology, the Second Hospital, Shandong University, Jinan, Shandong, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16331575

Citation

Lu, Qing-hua, et al. "[Plasma Activated Coagulation Factor VII and Msp I Polymorphism in Elderly Patients With Coronary Heart Disease]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 22, no. 6, 2005, pp. 691-3.
Lu QH, Du YM, Dong ZQ, et al. [Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(6):691-3.
Lu, Q. H., Du, Y. M., Dong, Z. Q., Lu, F. H., Wen, P. E., Wang, K. Z., Tian, Q., Sun, H., & Shang, Q. (2005). [Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 22(6), 691-3.
Lu QH, et al. [Plasma Activated Coagulation Factor VII and Msp I Polymorphism in Elderly Patients With Coronary Heart Disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(6):691-3. PubMed PMID: 16331575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease]. AU - Lu,Qing-hua, AU - Du,Yi-meng, AU - Dong,Zhao-qiang, AU - Lu,Fang-hong, AU - Wen,Pei-e, AU - Wang,Ke-zhi, AU - Tian,Qi, AU - Sun,Hui, AU - Shang,Qing, PY - 2005/12/7/pubmed PY - 2009/3/20/medline PY - 2005/12/7/entrez SP - 691 EP - 3 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 22 IS - 6 N2 - OBJECTIVE: To investigate the association of activated coagulation factor VII(F7a) and its gene Msp I polymorphism with coronary heart disease in elderly patients. METHODS: This was a case-control study, and the method of candidate gene was adopted. F7 genotypes were identified with polymerase chain reaction amplified genomic deoxyribonulieic acid (DNA) and Msp I restriction fragment length polymorphism analysis, and the level of plasma F7a was detected with recombinant tissue factor method for 108 elderly patients with coronary heart disease and 120 sex- and age-matched healthy control subjects. RESULTS: (1) Plasma F7a levels was significantly higher in elderly patients with coronary heart disease than in healthy control subjects (2.88 +/- 0.62 vs 2.58 +/- 0.60 microg/L, P < 0.05), and was significantly higher in old myocardial infarction than in stable angina pectoris (3.12 +/- 0.62 vs 2.76 +/- 0.60, P < 0.05). F7a was shown to be a risk factor for coronary heart disease in elderly patients by Logistic regression analysis (OR=1.21 P < 0.05). (2) The allelic frequencies were in accordance with Hardy-Weinberg equilibrium. The results suggested that the distribution of genotype and allelic frequencies in the groups displayed no significant difference, and there was no difference between the subgroups of coronary heart disease in elderly patients, either (P > 0.05). (3) F7a level was significantly higher in RR genotype than in Q allele carriers (2.72 +/- 0.60 vs 1.98 +/- 0.59 microg/L, P < 0.05) and was associated with F7 gene polymorphism. CONCLUSION: Plasma F7a level may be an independent risk factor of coronary heart disease in elderly patients, and it may be influenced by the Msp I polymorphism of F7 gene. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/16331575/[Plasma_activated_coagulation_factor_VII_and_Msp_I_polymorphism_in_elderly_patients_with_coronary_heart_disease]_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -