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The analysis of 1-propanol and 2-propanol in humid air samples using selected ion flow tube mass spectrometry.
Rapid Commun Mass Spectrom. 2006; 20(2):125-30.RC

Abstract

Following the observation that propanol is present in the breath samples of cystic fibrosis (CF) patients infected by Pseudomonas aeruginosa (PA), a study of the reactions of H(3)O(+), NO(+) and O(2) (+.) with 1-propanol and 2-propanol has been conducted using selected ion flow tube mass spectrometry (SIFT-MS). In this study the number and the distribution of the product ions from NO(+) reactions with the two propanol isomers under humid air conditions were able to differentiate between the two isomers. The reaction mechanisms and the structures of the product ions for these reactions, especially those with H(3)O(+) and NO(+), have been proposed. As an example, 2-propanol was shown to be present in a breath sample from one CF patient infected with PA, and also in a PA isolate from another CF patient grown on Pseudomonas-selective media. The results of this study allow an analytical procedure to be advanced for the analysis of the two propanol isomers, which can also be utilised in other applications.

Authors+Show Affiliations

Institute of Science and Technology in Medicine, Medical School, Keele University, Thornburrow Drive, Stoke-on-Trent ST4 7QB, UK. t.wang@pmed.keele.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16331744

Citation

Wang, Tianshu, et al. "The Analysis of 1-propanol and 2-propanol in Humid Air Samples Using Selected Ion Flow Tube Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 20, no. 2, 2006, pp. 125-30.
Wang T, Carroll W, Lenny W, et al. The analysis of 1-propanol and 2-propanol in humid air samples using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(2):125-30.
Wang, T., Carroll, W., Lenny, W., Boit, P., & Smith, D. (2006). The analysis of 1-propanol and 2-propanol in humid air samples using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 20(2), 125-30.
Wang T, et al. The Analysis of 1-propanol and 2-propanol in Humid Air Samples Using Selected Ion Flow Tube Mass Spectrometry. Rapid Commun Mass Spectrom. 2006;20(2):125-30. PubMed PMID: 16331744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The analysis of 1-propanol and 2-propanol in humid air samples using selected ion flow tube mass spectrometry. AU - Wang,Tianshu, AU - Carroll,Will, AU - Lenny,Warren, AU - Boit,Phillipa, AU - Smith,David, PY - 2005/12/7/pubmed PY - 2006/2/24/medline PY - 2005/12/7/entrez SP - 125 EP - 30 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 20 IS - 2 N2 - Following the observation that propanol is present in the breath samples of cystic fibrosis (CF) patients infected by Pseudomonas aeruginosa (PA), a study of the reactions of H(3)O(+), NO(+) and O(2) (+.) with 1-propanol and 2-propanol has been conducted using selected ion flow tube mass spectrometry (SIFT-MS). In this study the number and the distribution of the product ions from NO(+) reactions with the two propanol isomers under humid air conditions were able to differentiate between the two isomers. The reaction mechanisms and the structures of the product ions for these reactions, especially those with H(3)O(+) and NO(+), have been proposed. As an example, 2-propanol was shown to be present in a breath sample from one CF patient infected with PA, and also in a PA isolate from another CF patient grown on Pseudomonas-selective media. The results of this study allow an analytical procedure to be advanced for the analysis of the two propanol isomers, which can also be utilised in other applications. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/16331744/The_analysis_of_1_propanol_and_2_propanol_in_humid_air_samples_using_selected_ion_flow_tube_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.2285 DB - PRIME DP - Unbound Medicine ER -