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Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production.
Am J Clin Nutr. 2005 Dec; 82(6):1260-8; quiz 1365-6.AJ

Abstract

BACKGROUND

Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease.

OBJECTIVE

Our aim was to investigate the effects of isolated soy isoflavones on inflammatory biomarkers [von Willebrand factor, intracellular adhesion molecule 1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin, monocyte chemoattractant protein 1, C-reactive protein (CRP), and endothelin 1 concentrations]. Differences with respect to single-nucleotide polymorphisms in selected genes [estrogen receptor alpha (XbaI and PvuII), estrogen receptor beta [ERbeta (AluI) and ERbeta[cx] (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), and cholesteryl ester transfer protein (TaqIB)] and equol production were investigated.

DESIGN

One hundred seventeen healthy European postmenopausal women participated in this randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a washout period of 8 wk between the crossover. Plasma inflammatory factors were measured at 0 and 8 wk of each study arm.

RESULTS

Isoflavones improved CRP concentrations [odds ratio (95% CI) for CRP values >1 mg/L for isoflavone compared with placebo: 0.43 (0.27, 0.69)]; no significant effects of isoflavone treatment on other plasma inflammatory markers were observed. No significant differences in the response to isoflavones were observed according to subgroups of equol production. Differences in the VCAM-1 response to isoflavones and to placebo were found with ERbeta AluI genotypes.

CONCLUSION

Isoflavones have beneficial effects on CRP concentrations, but not on other inflammatory biomarkers of cardiovascular disease risk in postmenopausal women, and may improve VCAM-1 in an ERbeta gene polymorphic subgroup.

Authors+Show Affiliations

Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom. w.l.hall@reading.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16332659

Citation

Hall, Wendy L., et al. "Soy-isoflavone-enriched Foods and Inflammatory Biomarkers of Cardiovascular Disease Risk in Postmenopausal Women: Interactions With Genotype and Equol Production." The American Journal of Clinical Nutrition, vol. 82, no. 6, 2005, pp. 1260-8; quiz 1365-6.
Hall WL, Vafeiadou K, Hallund J, et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr. 2005;82(6):1260-8; quiz 1365-6.
Hall, W. L., Vafeiadou, K., Hallund, J., Bügel, S., Koebnick, C., Reimann, M., Ferrari, M., Branca, F., Talbot, D., Dadd, T., Nilsson, M., Dahlman-Wright, K., Gustafsson, J. A., Minihane, A. M., & Williams, C. M. (2005). Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. The American Journal of Clinical Nutrition, 82(6), 1260-8; quiz 1365-6.
Hall WL, et al. Soy-isoflavone-enriched Foods and Inflammatory Biomarkers of Cardiovascular Disease Risk in Postmenopausal Women: Interactions With Genotype and Equol Production. Am J Clin Nutr. 2005;82(6):1260-8; quiz 1365-6. PubMed PMID: 16332659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. AU - Hall,Wendy L, AU - Vafeiadou,Katerina, AU - Hallund,Jesper, AU - Bügel,Susanne, AU - Koebnick,Corinna, AU - Reimann,Manja, AU - Ferrari,Marika, AU - Branca,Francesco, AU - Talbot,Duncan, AU - Dadd,Tony, AU - Nilsson,Maria, AU - Dahlman-Wright,Karin, AU - Gustafsson,Jan-Ake, AU - Minihane,Anne-Marie, AU - Williams,Christine M, PY - 2005/12/8/pubmed PY - 2006/1/6/medline PY - 2005/12/8/entrez SP - 1260-8; quiz 1365-6 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 82 IS - 6 N2 - BACKGROUND: Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease. OBJECTIVE: Our aim was to investigate the effects of isolated soy isoflavones on inflammatory biomarkers [von Willebrand factor, intracellular adhesion molecule 1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin, monocyte chemoattractant protein 1, C-reactive protein (CRP), and endothelin 1 concentrations]. Differences with respect to single-nucleotide polymorphisms in selected genes [estrogen receptor alpha (XbaI and PvuII), estrogen receptor beta [ERbeta (AluI) and ERbeta[cx] (Tsp509I), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), and cholesteryl ester transfer protein (TaqIB)] and equol production were investigated. DESIGN: One hundred seventeen healthy European postmenopausal women participated in this randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a washout period of 8 wk between the crossover. Plasma inflammatory factors were measured at 0 and 8 wk of each study arm. RESULTS: Isoflavones improved CRP concentrations [odds ratio (95% CI) for CRP values >1 mg/L for isoflavone compared with placebo: 0.43 (0.27, 0.69)]; no significant effects of isoflavone treatment on other plasma inflammatory markers were observed. No significant differences in the response to isoflavones were observed according to subgroups of equol production. Differences in the VCAM-1 response to isoflavones and to placebo were found with ERbeta AluI genotypes. CONCLUSION: Isoflavones have beneficial effects on CRP concentrations, but not on other inflammatory biomarkers of cardiovascular disease risk in postmenopausal women, and may improve VCAM-1 in an ERbeta gene polymorphic subgroup. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16332659/Soy_isoflavone_enriched_foods_and_inflammatory_biomarkers_of_cardiovascular_disease_risk_in_postmenopausal_women:_interactions_with_genotype_and_equol_production_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/82.6.1260 DB - PRIME DP - Unbound Medicine ER -