Tags

Type your tag names separated by a space and hit enter

Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging.
Am J Clin Nutr 2005; 82(6):1346-52AJ

Abstract

BACKGROUND

Low folate status is associated with poor cognitive function and dementia in the elderly. Since 1998, grain products in the United States have been fortified with folic acid, which has reduced the prevalence of folate deficiency and hyperhomocysteinemia.

OBJECTIVE

We investigated whether folate status is associated with cognitive function and dementia in a cohort of elderly Latinos (aged >or= 60 y; n = 1789) exposed to folic acid fortification.

DESIGN

Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MSE) and specific cognitive functions by cross-culturally validated neuropsychological tests. Dementia was diagnosed according to the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 3rd edition revised, and California Alzheimer Disease Diagnostic and Treatment criteria. Red blood cell (RBC) folate was measured by automated chemiluminescence and total plasma homocysteine by HPLC.

RESULTS

The prevalence of folate deficiency (RBC folate <or= 160 ng/mL) was <1%. After control for confounding by homocysteine, vitamin B-12, creatinine, demographic variables, and depressive symptom score, RBC folate was directly associated with 3MSE (P = 0.005) and delayed recall (P = 0.007) scores. In addition, adjusted odds ratios for low 3MSE score (<or=78) and dementia diagnosis per unit increase in RBC folate were significantly below unity (P <or= 0.008), which indicated that the relative risks of cognitive impairment and dementia decreased with increasing RBC folate concentration. In contrast, adjusted odds ratios for low 3MSE score and dementia diagnosis per unit increase in homocysteine were not significant.

CONCLUSION

RBC folate is directly associated with cognitive function scores and is inversely associated with dementia in elderly Latinos despite folic acid fortification.

Authors+Show Affiliations

School of Medicine, Department of Medical Pathology, University of California, Davis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16332669

Citation

Ramos, Marisa I., et al. "Low Folate Status Is Associated With Impaired Cognitive Function and Dementia in the Sacramento Area Latino Study On Aging." The American Journal of Clinical Nutrition, vol. 82, no. 6, 2005, pp. 1346-52.
Ramos MI, Allen LH, Mungas DM, et al. Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. Am J Clin Nutr. 2005;82(6):1346-52.
Ramos, M. I., Allen, L. H., Mungas, D. M., Jagust, W. J., Haan, M. N., Green, R., & Miller, J. W. (2005). Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. The American Journal of Clinical Nutrition, 82(6), pp. 1346-52.
Ramos MI, et al. Low Folate Status Is Associated With Impaired Cognitive Function and Dementia in the Sacramento Area Latino Study On Aging. Am J Clin Nutr. 2005;82(6):1346-52. PubMed PMID: 16332669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. AU - Ramos,Marisa I, AU - Allen,Lindsay H, AU - Mungas,Dan M, AU - Jagust,William J, AU - Haan,Mary N, AU - Green,Ralph, AU - Miller,Joshua W, PY - 2005/12/8/pubmed PY - 2006/1/6/medline PY - 2005/12/8/entrez SP - 1346 EP - 52 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 82 IS - 6 N2 - BACKGROUND: Low folate status is associated with poor cognitive function and dementia in the elderly. Since 1998, grain products in the United States have been fortified with folic acid, which has reduced the prevalence of folate deficiency and hyperhomocysteinemia. OBJECTIVE: We investigated whether folate status is associated with cognitive function and dementia in a cohort of elderly Latinos (aged >or= 60 y; n = 1789) exposed to folic acid fortification. DESIGN: Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MSE) and specific cognitive functions by cross-culturally validated neuropsychological tests. Dementia was diagnosed according to the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 3rd edition revised, and California Alzheimer Disease Diagnostic and Treatment criteria. Red blood cell (RBC) folate was measured by automated chemiluminescence and total plasma homocysteine by HPLC. RESULTS: The prevalence of folate deficiency (RBC folate <or= 160 ng/mL) was <1%. After control for confounding by homocysteine, vitamin B-12, creatinine, demographic variables, and depressive symptom score, RBC folate was directly associated with 3MSE (P = 0.005) and delayed recall (P = 0.007) scores. In addition, adjusted odds ratios for low 3MSE score (<or=78) and dementia diagnosis per unit increase in RBC folate were significantly below unity (P <or= 0.008), which indicated that the relative risks of cognitive impairment and dementia decreased with increasing RBC folate concentration. In contrast, adjusted odds ratios for low 3MSE score and dementia diagnosis per unit increase in homocysteine were not significant. CONCLUSION: RBC folate is directly associated with cognitive function scores and is inversely associated with dementia in elderly Latinos despite folic acid fortification. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16332669/Low_folate_status_is_associated_with_impaired_cognitive_function_and_dementia_in_the_Sacramento_Area_Latino_Study_on_Aging_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/82.6.1346 DB - PRIME DP - Unbound Medicine ER -