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Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient.
Jpn J Clin Oncol. 2005 Dec; 35(12):753-6.JJ

Abstract

We report a rare case in which two tumor entities, a gastrointestinal stromal tumor (GIST) and Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), with distinct cytogenetic features occurred in a single patient. The patient was a 72-year-old woman. The first tumor was a submucosal gastric tumor and was diagnosed as a low-risk group GIST based on morphological characteristics and the results of an immunohistochemical analysis for c-kit and CD34. Further cytogenetic analysis revealed that this tumor had a point mutation (D842V substitution) in exon 18 of the platelet-derived growth factor receptor alpha gene. The second tumor was found more than 4 years after the appearance of the first tumor. ES/PNET was highly suspected both morphologically and immunohistochemically, and the diagnosis was confirmed by the detection of an EWS rearrangement using a fluorescence in situ hybridization technique. Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ.

Authors+Show Affiliations

Divison of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16332719

Citation

Kondo, Shunsuke, et al. "Cytogenetic Confirmation of a Gastrointestinal Stromal Tumor and Ewing Sarcoma/primitive Neuroectodermal Tumor in a Single Patient." Japanese Journal of Clinical Oncology, vol. 35, no. 12, 2005, pp. 753-6.
Kondo S, Yamaguchi U, Sakurai S, et al. Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient. Jpn J Clin Oncol. 2005;35(12):753-6.
Kondo, S., Yamaguchi, U., Sakurai, S., Ikezawa, Y., Chuman, H., Tateishi, U., Furuta, K., & Hasegawa, T. (2005). Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient. Japanese Journal of Clinical Oncology, 35(12), 753-6.
Kondo S, et al. Cytogenetic Confirmation of a Gastrointestinal Stromal Tumor and Ewing Sarcoma/primitive Neuroectodermal Tumor in a Single Patient. Jpn J Clin Oncol. 2005;35(12):753-6. PubMed PMID: 16332719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient. AU - Kondo,Shunsuke, AU - Yamaguchi,Umio, AU - Sakurai,Shinji, AU - Ikezawa,Yoshisuke, AU - Chuman,Hirokazu, AU - Tateishi,Ukihide, AU - Furuta,Koh, AU - Hasegawa,Tadashi, Y1 - 2005/12/06/ PY - 2005/12/8/pubmed PY - 2006/3/4/medline PY - 2005/12/8/entrez SP - 753 EP - 6 JF - Japanese journal of clinical oncology JO - Jpn. J. Clin. Oncol. VL - 35 IS - 12 N2 - We report a rare case in which two tumor entities, a gastrointestinal stromal tumor (GIST) and Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), with distinct cytogenetic features occurred in a single patient. The patient was a 72-year-old woman. The first tumor was a submucosal gastric tumor and was diagnosed as a low-risk group GIST based on morphological characteristics and the results of an immunohistochemical analysis for c-kit and CD34. Further cytogenetic analysis revealed that this tumor had a point mutation (D842V substitution) in exon 18 of the platelet-derived growth factor receptor alpha gene. The second tumor was found more than 4 years after the appearance of the first tumor. ES/PNET was highly suspected both morphologically and immunohistochemically, and the diagnosis was confirmed by the detection of an EWS rearrangement using a fluorescence in situ hybridization technique. Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ. SN - 0368-2811 UR - https://www.unboundmedicine.com/medline/citation/16332719/Cytogenetic_confirmation_of_a_gastrointestinal_stromal_tumor_and_ewing_sarcoma/primitive_neuroectodermal_tumor_in_a_single_patient_ L2 - https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyi197 DB - PRIME DP - Unbound Medicine ER -