Tags

Type your tag names separated by a space and hit enter

[Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination].
Cas Lek Cesk. 2005; 144(11):737-41.CL

Abstract

BACKGROUND

The aim of the study was to determine how addition of n-3 polyenic fatty acids (PUFA) to the present treatment with statin + fibrate combination in diabetic dyslipidemia effects plasma lipids and lipoproteins, LDL lipoperoxidation, glucose homeostasis, concentration of serum homocysteine and selected inflammation indicators.

METHODS AND RESULTS

24 patients with type 2 diabetes, who after the combined hypolipidemic treatment (pravastatin 20 mg + micronized fenofibrate 200 mg per day) cannot reach the recommended target values for long time, received for three consecutive months supplementation of 3,6 g PUFA n-3 per day or a placebo (olive oil). At the beginning of the study, after three months of PUFA supplementation and after another three months of placebo administration, concentrations of plasma lipids, composition of fatty acids, plasma phosphatidylcholine (PC), cholesterol esters (CE) and triglycerides (TG), concentration of tHcy, conjugated diens (CD) in LDL and selected inflammation indicators (IL-6, TNFalpha, VCAM-1) were determined. n-3 PUFA supplementation resulted in the significant decrease of tHcy concentration (-29%, P < 0.01) and TG (-28%, P < 0.05) in plasma. During the period of placebo administration, values returned to base line levels. CD concentration in LDL after n-3 PUFA increased by 15% (P < 0.15, not significant), meanwhile after the placebo containing oleic acid it decreased by 18% (P < 0.05).

CONCLUSIONS

Our results show that n-3 PUFA supplementation together with statin + fibrate combination in DDL patients can significantly decrease the risk of cardiovascular diseases.

Authors+Show Affiliations

IV. interní klinika 1. LF UK a VFN, Praha. zemanm@vfn.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
English Abstract
Journal Article

Language

cze

PubMed ID

16335699

Citation

Zeman, M, et al. "[Effect of N-3 Polyunsaturated Fatty Acids On Plasma Lipid, LDL Lipoperoxidation, Homocysteine and Inflammation Indicators in Diabetic Dyslipidemia Treated With Statin + Fibrate Combination]." Casopis Lekaru Ceskych, vol. 144, no. 11, 2005, pp. 737-41.
Zeman M, Zák A, Vecka M, et al. [Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination]. Cas Lek Cesk. 2005;144(11):737-41.
Zeman, M., Zák, A., Vecka, M., Tvrzická, E., Písaríková, A., & Stanková, B. (2005). [Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination]. Casopis Lekaru Ceskych, 144(11), 737-41.
Zeman M, et al. [Effect of N-3 Polyunsaturated Fatty Acids On Plasma Lipid, LDL Lipoperoxidation, Homocysteine and Inflammation Indicators in Diabetic Dyslipidemia Treated With Statin + Fibrate Combination]. Cas Lek Cesk. 2005;144(11):737-41. PubMed PMID: 16335699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination]. AU - Zeman,M, AU - Zák,A, AU - Vecka,M, AU - Tvrzická,E, AU - Písaríková,A, AU - Stanková,B, PY - 2005/12/13/pubmed PY - 2006/1/25/medline PY - 2005/12/13/entrez SP - 737 EP - 41 JF - Casopis lekaru ceskych JO - Cas Lek Cesk VL - 144 IS - 11 N2 - BACKGROUND: The aim of the study was to determine how addition of n-3 polyenic fatty acids (PUFA) to the present treatment with statin + fibrate combination in diabetic dyslipidemia effects plasma lipids and lipoproteins, LDL lipoperoxidation, glucose homeostasis, concentration of serum homocysteine and selected inflammation indicators. METHODS AND RESULTS: 24 patients with type 2 diabetes, who after the combined hypolipidemic treatment (pravastatin 20 mg + micronized fenofibrate 200 mg per day) cannot reach the recommended target values for long time, received for three consecutive months supplementation of 3,6 g PUFA n-3 per day or a placebo (olive oil). At the beginning of the study, after three months of PUFA supplementation and after another three months of placebo administration, concentrations of plasma lipids, composition of fatty acids, plasma phosphatidylcholine (PC), cholesterol esters (CE) and triglycerides (TG), concentration of tHcy, conjugated diens (CD) in LDL and selected inflammation indicators (IL-6, TNFalpha, VCAM-1) were determined. n-3 PUFA supplementation resulted in the significant decrease of tHcy concentration (-29%, P < 0.01) and TG (-28%, P < 0.05) in plasma. During the period of placebo administration, values returned to base line levels. CD concentration in LDL after n-3 PUFA increased by 15% (P < 0.15, not significant), meanwhile after the placebo containing oleic acid it decreased by 18% (P < 0.05). CONCLUSIONS: Our results show that n-3 PUFA supplementation together with statin + fibrate combination in DDL patients can significantly decrease the risk of cardiovascular diseases. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/16335699/[Effect_of_n_3_polyunsaturated_fatty_acids_on_plasma_lipid_LDL_lipoperoxidation_homocysteine_and_inflammation_indicators_in_diabetic_dyslipidemia_treated_with_statin_+_fibrate_combination]_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -